Ask about this productRelated genes to: VMAT2 antibody
- Gene:
- SLC18A2 NIH gene
- Name:
- solute carrier family 18 member A2
- Previous symbol:
- VMAT2
- Synonyms:
- SVMT, SVAT
- Chromosome:
- 10q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-25
- Date modifiied:
- 2016-10-05
Related products to: VMAT2 antibody
Related articles to: VMAT2 antibody
- This study was conducted to systematically elucidate the molecular regulatory mechanisms underlying egg production traits in indigenous chickens. Using a self-bred White-feathered Green-shelled (WG) chicken line as the research subject, high-yield and low-yield individuals were selected based on egg numbers at 43 weeks (EN43). Hypothalamus, pituitary, and ovarian tissues were collected from these individuals for targeted metabolomics profiling and transcriptome sequencing. The results showed a significant difference in EN43 between the two groups (P < 0.05). Targeted metabolomics of ovarian tissue detected a total of 17 steroid hormones, among which pregnenolone, progesterone, and 17β-estradiol were identified as differentially expressed steroid hormones (DESHs) between the two groups. Differential expression analysis of transcriptomes identified 666, 149, and 69 differentially expressed genes (DEGs) in the hypothalamus, pituitary, and ovary, respectively. Functional enrichment analysis revealed that hypothalamic DEGs were primarily involved in transcriptional regulation, neuropeptide signaling, and neurodevelopmental processes. Pituitary DEGs were mainly enriched in synaptic plasticity, calcium ion binding, and neurotransmitter transport, while ovarian DEGs were predominantly associated with signal transduction, calcium signaling regulation, and the cGMP signaling pathway. A molecular regulatory network (MRN) was constructed based on DEGs and DESHs. Through modular analysis, four key regulatory modules were identified, involving neuroendocrine regulation, neurotransmitter transport, steroid hormone synthesis, and transcriptional/developmental regulation. Combined with comprehensive network topology scoring, 25 potential candidate genes were identified, including POMC, NPY, CRH, SLC18A2, CD36, EGF, and WNT3A. In conclusion, this study integrated multi-omics data to reveal the molecular mechanisms of the HPO axis regulating egg production traits from a multi-tissue and multi-level perspective, providing a theoretical foundation for molecular breeding in indigenous poultry. - Source: PubMed
Publication date: 2026/07/27
Liu HangWei YinghuiWang YanluZhou YuanhaoZhang LeiZhang WeiwuFan JinghuiWang Huanhuan - Respiratory diseases significantly impair pig growth performance by reducing average daily gain and feed conversion efficiency. Pneumonia lesion score (PLS) is a reliable phenotypic indicator for detecting respiratory issues in pig herds, including subclinical infections that often remain undiagnosed. In this study, PLS data was collected from 327 Large White pigs, and whole-genome resequencing (WGS) was performed. Lung tissue samples from pigs with extremely high and low PLS values were subjected to transcriptomic sequencing and Fixation Index (F) analysis. Additionally, a transcriptome-wide association study (TWAS) was conducted using FarmGTEx prediction models based on blood and lung tissues. - Source: PubMed
Publication date: 2026/07/20
Zhao GuankaiYin YanzhenHan JunzhaoChen JianmeiLi MengyuHan XiangyuMa JinfengYu JianghuiZhou JinChen ChifengHuang RuihuaLi PinghuaZhao Qingbo - Dopaminergic neurons are vulnerable to injury from gliosis and have high density of ACE2 receptors, but the integrity of dopaminergic neurons has not been investigated in long COVID. This study examined whether vesicular monoamine transporter 2 (VMAT2) binding, index of dopamine-releasing neuron density, is reduced in the striatum in long COVID and associated with neuropsychiatric symptoms. - Source: PubMed
Publication date: 2026/07/10
Liu Yuhan KaridaPersaud DevinaVieira Erica LBraga JoeffreRusjan PabloMiler LauraRabin Jennifer SMcCluskey TinaBoileau IsabelleChao ThomasBagby MichaelNarciso LucasGray Lauren RoseVasdev NeilDesmond KimberlyKloiber StefanWarsh JerryHusain Muhammad IshratSmart KellyWang WeiMeyer Jeffrey H - Prostate cancer is one of the most common malignant tumors of the male genitourinary system. The impaired activity of natural killer (NK) cells observed in prostate cancer may contribute to immune evasion. This study aimed to develop robust NK cell-related diagnostic signatures. - Source: PubMed
Publication date: 2026/06/03
Chen ZhengjunZhou FangTian JingzhiLv QianWang DongFan Shida - A complex structural variation on chicken chromosome 27 is the causal mutation for the muffs and beard (Mb) phenotype. The Mb variant region contains copy number variations in several genes important for nervous system development, including HOXB8, HOXB7, and SMARCE1. However, it was previously unknown whether genes in this region are expressed in the brain or influence neural development. In this study, we collected embryonic brain tissues from Beijing-You Mb and non-Mb chickens at different developmental time points. RT-qPCR revealed that SMARCD2, HOXB8, SMARCE1, and KRT222 were highly expressed in Mb chicken brains. HOXB8 showed stable differential expression after day 15 and had the highest fold change among all differentially expressed genes (DEGs). RNA-seq of 19-day brain tissue indicated that DEGs were enriched in neural development processes such as synaptic assembly, signal transduction, chemical synaptic transmission, and neurotransmitter regulation. Several key neural development genes were also differentially expressed, providing a biological basis for developmental difference. Neurotransmitter analysis further revealed significant differences in glutamate and GABA levels. HOXB8, an important regulator of neural development, showed widespread mRNA expression in brain sections, especially in cortical tissues, and its homeobox domain is evolutionarily conserved. Overexpression of HOXB8 in chicken embryo primary brain cells significantly regulated multiple neural development-related genes, including AGT, SLC32A1, SLC18A2, RPS20, RPL35A, SLC6A11, and RLN3. In conclusion, this study is the first to show that genes within the Mb region are highly expressed in chicken embryonic brain tissue and mediate differences in neural development-related gene expression and neurotransmitter content, with HOXB8 as a key candidate. These findings open a new avenue for research on the Mb variant in neural development, and future work should further investigate neurological and behavioral differences in Mb chickens. - Source: PubMed
Publication date: 2026/06/02
Zheng XiaotongLiu LiNiu ZiqiuLi YimengLiu ZhengyangShu XinWang HuiXu BingjieWang YutongChen JianfeiZhang Hao