Ask about this productRelated genes to: MSI1 antibody
- Gene:
- MSI1 NIH gene
- Name:
- musashi RNA binding protein 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-05-07
- Date modifiied:
- 2016-11-09
Related products to: MSI1 antibody
Related articles to: MSI1 antibody
- Neuroblastoma remains a major cause of pediatric cancer mortality and although intensive multimodal treatment strategies have improved survival, they have also led to an increased risk of long-term treatment-related toxicities among survivors. This study aimed to evaluate the potential involvement of (Musashi) Msi1 in neuroblastoma oncogenesis and etoposide treatment response. - Source: PubMed
Cochran Elizabeth DQiao JingboMachchhar ArtiJacobson Jillian CMcCreery SullivanChung Dai H - Musashi RNA-binding proteins are important post-transcriptional regulators of stem cell homeostasis and are known to be involved in viral infections. However, their role in SARS-CoV-2 infection remains largely unknown. Using computational studies, in vivo RNA immunoprecipitation, and biochemical assays, here, we establish that Musashi 1 (Msi1) interacts with viral genomic RNA through direct binding to the SARS-CoV-2 3'UTR. Importantly, binding of Msi1 to the viral 3'UTR results in translational repression that could be mediated by inhibition of poly(A) binding protein. Conversely, Msi1 knockout promotes robust viral replication and increased viral protein expression. Using 2D cell cultures, stem cells, and 3D organoids, we show that depletion of Msi1 in intestinal cells augments infection. This finding explains why the human intestine serves as a reservoir for SARS-CoV-2, in which differentiated enterocytes with negligible Msi1 levels are particularly affected. Contrarily, stem cells, which are enriched for Msi1 expression, are known to be less permissive to SARS-CoV-2 infection despite expressing the entry receptors. Our findings show how translational repression of SARS-CoV-2 by stem cell RNA-binding proteins, such as Msi1, could help evade infection. - Source: PubMed
Ganguli SouravGupta DivyaKadumuri Rajashekar VarmaTandel DixitRamaswamy RajashreeKrishnan Aswathy GDavid Deena TBunk SoumyaChavali SreenivasHarshan Krishnan HarinivasChavali Pavithra L - - Source: PubMed
Jing Hongwei - Polycomb repressive complex 2 (PRC2) is a conserved multi-protein complex that catalyzes histone H3 trimethylation at lysine 27 (H3K27me3), an epigenetic mark associated with transcriptional repression. However, the mechanistic link between PRC2-mediated H3K27me3 and light-regulated hypocotyl elongation during photomorphogenesis remains largely unexplored. In this study, we identify the MULTICOPY SUPPRESSOR OF IRA1 (MSI1), a core component of PRC2, as a negative regulator of hypocotyl elongation under light conditions in Arabidopsis thaliana. MSI1 physically interacts with ELONGATED HYPOCOTYL 5 (HY5), a basic leucine zipper (bZIP) transcription factor central to photomorphogenic signaling, in vitro and in vivo. Genetic and molecular analyses reveal that MSI1 is indispensable for HY5-mediated repression of hypocotyl growth, suggesting a cooperative function between chromatin-based silencing and transcriptional regulation. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) showed that MSI1 and HY5 co-occupy numerous genomic loci. HY5 facilitates PRC2 complex recruitment to the target genes by interacting with MSI1, thereby promoting H3K27me3 deposition and repressing gene expression. Furthermore, transcriptomic profiling reveals that MSI1 and HY5 jointly suppress a subset of genes involved in auxin signaling, providing mechanistic insight into their role in photomorphogenesis. Together, our findings uncover an epigenetic mechanism by which HY5 recruits PRC2 through MSI1 to modulate light-responsive growth. - Source: PubMed
Xu YingchaoWang MinYu Mei-HuiLiu YanLiao Wen-ChiLi TaoHung Fu-YuGao SujuanXie DasenWu KeqiangYang Songguang - RNA-binding proteins (RBPs) play a pivotal role in post-transcriptional gene regulation, influencing various cellular processes, including development, differentiation, and disease progression. Emerging evidence suggests that RBPs function as critical modulators of the canonical Wnt signaling pathway, a key regulator of cell fate determination, proliferation, and tumorigenesis. By controlling the stability, localization, and translation of Wnt pathway components, RBPs fine-tune the dynamic signaling responses necessary for maintaining cellular homeostasis. Several RBPs have been identified as direct regulators of key components in the Wnt cascade, such as IGF2BP1, HuR, and MSI1, impacting their expression and activity. Dysregulation of these RBPs has been linked to aberrant Wnt signaling, contributing to various pathological conditions such as cancers or developmental disorders. This review explores the emerging landscape of RBPs in the regulation of canonical Wnt signaling, highlighting their molecular mechanism, functional implications, and potential as therapeutic targets in Wnt-driven disease. - Source: PubMed
Publication date: 2025/12/24
Czap Michael SSingh VikashSpiegelman Vladimir S