Ask about this productRelated genes to: BRCAA1 antibody
- Gene:
- ARID4B NIH gene
- Name:
- AT-rich interaction domain 4B
- Previous symbol:
- RBP1L1
- Synonyms:
- BCAA, BRCAA1, SAP180
- Chromosome:
- 1q42.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-28
- Date modifiied:
- 2015-11-17
Related products to: BRCAA1 antibody
Related articles to: BRCAA1 antibody
- Ocean warming imposes significant physiological challenges on marine ectotherms, including bivalves, whose physiological processes are closely linked to ambient environmental conditions. In this study, bottom-sown cultured scallop Patinopecten yessoensis were collected in June (10.5 °C, BS6), July (13.5 °C, BS7), and August (19.5 °C, BS8). Transcriptomic analyses were conducted across these time points to investigate the molecular responses of scallops to summer seawater warming. Membrane stabilization and basal lipid metabolic activity were evident in the BS6 group. The BS7 group displayed a transitional metabolic reconfiguration. In contrast, the BS8 group exhibited a pronounced enhancement of glycolipid metabolism and metabolic reprogramming. Further gene set enrichment analysis of pairwise comparisons among the three groups consistently revealed enrichment of spliceosome, RNA transport, and protein processing in the endoplasmic reticulum pathways. Replicate multivariate analysis of transcript splicing identified dynamic alternative splicing events across the three groups, with skipped exon events predominating. Notably, AT-rich interaction domain 4B (ARID4B) exhibited temperature-associated alternative splicing within its DNA-binding domain, where exon 7 was predominantly included in the BS6 group but absent in the BS8 group. Collectively, the most representative adaptive feature in P. yessoensis under summer seawater warming is the systematic enhancement of post-transcriptional regulation, characterized by dynamic alternative splicing. These findings provide a transcriptomic framework for understanding how glycolipid metabolic reprogramming and post-transcriptional regulation are coordinated to support scallop resilience under ocean warming. - Source: PubMed
Publication date: 2026/04/06
Lu HongboZhang MingyueYang ChuanyanJiang DongliKang XinZhang QiuyuWang LinglingSong Linsheng - Epithelial–mesenchymal transition and cancer cell stemness (CSC) are critical processes that driving the invasion and lethality of lung adenocarcinoma (LUAD). The chromatin remodeler has been implicated in other cancers; however, its specific role and underlying mechanism in LUAD progression remain unclear. - Source: PubMed
Publication date: 2026/03/04
Huang GuangnanGao LeiFang ShuXu LikunZhao Xiaowei - HOXB5, a member of the homeobox (HOX) gene family. Its dysregulated expression has been increasingly reported across multiple human cancers, where it correlates with malignant progression and poor clinical outcomes. A concise synthesis of its regulatory networks and cancer-associated functions is therefore needed to clarify its biological and translational significance. - Source: PubMed
Publication date: 2026/01/06
Zhong KuiYi QiangChen ZhengXu YongchangZeng YangnengZhong Jinghua - Previous study found that mitochondrial might correlate with sepsis-induced acute respiratory distress syndrome (ARDS). Thus, this study aimed to find the effect of mitochondrial-related biomarkers in sepsis-induced ARDS. Differentially expressed genes (DEGs) were firstly screened in sepsis-induced ARDS datasets and intersected with mitochondrial-related genes (MRGs) to create differentially expressed-MRGs (DE-MRGs). Based on DE-MRGs, three machine learning algorithms were further performed to yield feature genes, the intersections of feature genes were conducted expression analysis. Those genes with significant difference of expression were identified as biomarkers for nomogram construction and immune infiltration. Single cell RNA sequencing (scRNA-seq) analysis was processed to annotate cell subpopulations, the expression of biomarkers was evaluated in different cell subpopulations. Finally, the expression of biomarkers was validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting. Relied on comprehensive analysis, three biomarkers (ARID4B, RGS2, TGM2) related to mitochondrial were acquired for sepsis-induced ARDS. A nomogram was then constructed relied on biomarkers, and verified to have an excellent performance. Analysis of immune infiltration showed that naive B cells and CD8 T cells had significant difference between different groups. Neutrophils were likewise found to be positively correlated with RGS2 (cor = 0.39, p < 0.05). 13 distinct cell subpopulations were annotated, and RGS2 had the highest expression in myofibroblast. Finally, the expression of ARID4B and RGS2 was stably downregulated in sepsis-induced ARDS. In this study, three biomarkers (ARID4B, RGS2, and TGM2) for sepsis-induced ARDS were found, which provided theoretical basis for the diagnose and treatment for the disease. - Source: PubMed
Publication date: 2026/01/05
He YingCheng YunZhang HanXing ZhouxiongFu BaoFu Xiaoyun - Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been implicated in the regulation of gene expression in teratozoospermia, but the specific mechanisms are not fully understood. This study aimed to identify differentially expressed genes (DEGs) between teratozoospermia and normozoospermia samples, and to investigate the role of epigenetic regulatory factors in the observed gene expression changes. The study integrated data from three publicly available datasets in the GSE6969 superseries. The DEGs were compared to a list of known human epigenetic-related genes obtained from the EpiFactors database. The protein-protein interaction (PPI) network and hub gene identifications for Epi-DEGs and the RNA-protein interaction (RPI) network to obtained the RBPs interacting with Epi-DEGs were constructed. siRNA design for the candidate mRNA was performed using various bioinformatics tools. As a result, the obtained 1,292 DEGs were compared to a list of 796 known human epigenetic factors, revealing 63 Epi-DEGs. The PPI network of Epi-DEGs identified top 10 hub genes including , , , , , , , , and . The RPI network analysis revealed , and as key RNA-binding protein regulators epigenetic modifiers. Based on these findings, the study designed the sequence GCAACAAGAGAAGAA GCAATT as an optimal siRNA candidate targeting the master regulator IGF2BP2, which exhibited the most significant change in expression among the RNA-binding proteins (RBPs). This integrative analysis sheds light on the epigenetic mechanisms underlying teratozoospermia and highlights the potential of RBPs as diagnostic biomarkers and therapeutic targets for further investigation. - Source: PubMed
Mousavi Seyedeh ZahraMohammad-Soltani BahramHadizadeh MortezaRokhsattalab ZeynabTotonchi Mehdi