Ask about this productRelated genes to: GLUT10 antibody
- Gene:
- SLC2A10 NIH gene
- Name:
- solute carrier family 2 member 10
- Previous symbol:
- -
- Synonyms:
- GLUT10
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-02
- Date modifiied:
- 2016-02-17
- Gene:
- SLC2A11 NIH gene
- Name:
- solute carrier family 2 member 11
- Previous symbol:
- -
- Synonyms:
- GLUT11, GLUT10
- Chromosome:
- 22q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-14
- Date modifiied:
- 2016-02-17
Related products to: GLUT10 antibody
Related articles to: GLUT10 antibody
- Facilitative glucose transporters (GLUTs), which are encoded by solute carrier 2A () genes, are responsible for mediating glucose absorption. In order to meet their higher energy demands, cancer cells are more likely than normal tissue cells to have elevated glucose transporters. Multiple pathogenic processes, such as cancer and immunological disorders, have been linked to GLUTs. Few studies, meanwhile, have been conducted on individuals with lung adenocarcinoma (LUAD) to evaluate all 14 genes. We first identified increased protein levels of , , , and HPA database and downregulated mRNA levels of , , , and by ONCOMINE and UALCAN databases in patients with LUAD. Additionally, lower levels of , , , , and and higher levels of , , , and had an association with advanced tumor stage. , , and were identified as prognostic signatures for LUAD. Kaplan-Meier analysis, Univariate Cox regression, multivariate Cox regression and ROC analyses further revealed that these three genes signature was a novel and important prognostic factor. Mechanistically, the aberrant expression of these molecules was caused, in part, by the hypomethylation of , , and and by the hypermethylation of , , , , , and . Additionally, , , , , and contributed to LUAD by positively modulating M2 macrophage and T cell exhaustion. Finally, pathways involving /BUB1B/mitotic cell cycle, /CD86/negative regulation of immune system process, /PLEK/lymphocyte activation, /CD4/regulation of cytokine production might participate in the pathogenesis of LUAD. In summary, our results will provide the theoretical basis on as diagnostic markers and therapeutic targets in LUAD. - Source: PubMed
Publication date: 2022/11/28
Zhang YanliQin HanBian JingMa ZhanchuanYi Huanfa - Mammalian cells use glucides as a substrate that can be catabolized through glycolitic pathways or oxidative phosphorylation, used as a source of reducing potential, or used for anabolic aims. An important role in supplying cells with energy is played by different membrane proteins that can actively (sodium-dependent glucose transporters) or passively (glucose transporters; GLUT) transport hexoses through the lipidic bilayer. In particular, GLUTs are a family of 13 proteins that facilitate the transport of sugars and have a peculiar distribution in different tissues as well as a particular affinity for substrates. These proteins are also present in mature sperm cells, which, in fact, need carriers for uptake energetic sources that are important for maintaining cell basic activity as well as specific functions, such as motility and fertilization ability. Likewise, several GLUTs have been studied in various mammalian species (man, bull, rat, mouse, boar, dog, stallion, and donkey) to point out both their actual presence or absence and their localization on plasma membrane. The aim of this work is to give an overall picture of the studies available on GLUTs in mammalian spermatozoa at this moment, pointing out the species peculiarity, the possible role of these proteins, and the potential future research on this item. - Source: PubMed
Publication date: 2010/11/18
Bucci DiegoRodriguez-Gil Juan EnriqueVallorani ClaudiaSpinaci MarcellaGaleati GiovannaTamanini Carlo - The protein family of facilitative glucose transporters comprises 14 isoforms that share common structural features such as 12 transmembrane domains, N- and C-termini facing the cytoplasm of the cell, and a N-glycosylation side either within the first or fifth extracellular loop. Based on their sequence homology, three classes can be distinguished: class I includes GLUT1-4 and GLUT14, class II the "odd transporters" GLUT5, 7, 9, 11, and class III the "even transporters" GLUT6, 8, 10, 12 and the proton driven myoinositol transporter HMIT (or GLUT13). With the cloning and characterization of the more recent class II and III isoforms, it became apparent that despite their structural similarities, the different isoforms not only show a distinct tissue-specific expression pattern but also show distinct characteristics such as alternative splicing, specific (sub)cellular localization, and affinities for a spectrum of substrates. This review summarizes the current understanding of the physiological role for the various transport facilitators based on human genetically inherited disorders or single-nucleotide polymorphisms and knockout mice models. The emphasis of the review will be on the potential functional role of the more recent isoforms. - Source: PubMed
Augustin Robert