Ask about this productRelated genes to: FBG4 antibody
- Gene:
- FBXO17 NIH gene
- Name:
- F-box protein 17
- Previous symbol:
- FBXO26
- Synonyms:
- FBG4, FLJ25205, MGC9379, FLJ11798, Fbx17
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-22
- Date modifiied:
- 2015-09-11
Related products to: FBG4 antibody
Related articles to: FBG4 antibody
- Circular RNAs (circRNAs) have emerged as key post-transcriptional regulators in cancer progression through their ability to modulate microRNA (miRNA) activity. However, the functional role and regulatory mechanisms of many circRNAs in prostate cancer (PCa) remain poorly understood. This study investigates the oncogenic potential of circFAM120B (hsa_circ_0001666) and its regulatory interaction with miR-1182 and FBXO17 in PCa. CircFAM120B expression was assessed in PCa tissues and cell lines using qRT-PCR and confirmed by Sanger sequencing and RNase R digestion. Functional assays, including CCK-8, EdU, colony formation, wound healing, Transwell, and flow cytometry, were performed to evaluate the effects of circFAM120B knockdown. RNA pull-down, dual-luciferase reporter, and rescue assays were conducted to investigate the molecular interaction between circFAM120B, miR-1182, and FBXO17. Additionally, a xenograft tumor model was used to validate in vivo tumorigenic effects. CircFAM120B was significantly upregulated in PCa tissues and cells and exhibited high cytoplasmic stability. Knockdown of circFAM120B suppressed PCa cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) while promoting apoptosis. Mechanistically, circFAM120B functioned as a sponge for miR-1182, thereby relieving its suppression of FBXO17. This axis led to activation of the AKT signaling pathway, which was attenuated following circFAM120B knockdown. Rescue experiments with a miR-1182 inhibitor confirmed that circFAM120B exerts its oncogenic effects via the miR-1182/FBXO17/AKT axis. In vivo, circFAM120B knockdown reduced tumor growth and metastatic potential in a PCa xenograft model. CircFAM120B promotes PCa progression by sponging miR-1182 and upregulating FBXO17 expression. Targeting the circFAM120B/miR-1182/FBXO17 axis may represent a novel therapeutic strategy for PCa. - Source: PubMed
Publication date: 2026/01/06
Wan ZijinLiu Gang - Cancer stem cells are associated with tumorigenesis, aggression, and drug resistance. We aimed to identify stem cell-related subtypes and a prognostic tool, and to investigate potential stem cell-related genes contributing to high-grade serous ovarian cancer (HGSOC). - Source: PubMed
Publication date: 2025/07/23
Wu HuijuanLi DanSun LuSong HualinWang Ke - Human endogenous retroviruses (HERVs), which are normally silenced by methylation or mutation, can be reactivated by a variety of environmental factors, including infection with exogenous viruses. In this work, we investigated the transcriptional activity of HERVs following infection of human liver cells (HepaRG) with human adenovirus C serotype 5 (HAdV-C5). HAdV-C5 infection results in reactivation of several HERV groups as well as differentially expressed genes. Interestingly, in HAdV-C5 infection, upregulated genes that were in close chromosomal proximity to upregulated HERV loci were associated with influencing viral carcinogenesis and inflammatory signaling. We also identified an FBXO17 transcript encoding an intronic ERVK9-11 sense sequence upon HAdV-C5 infection. FBXO17 has previously been described as an important factor in the regulation of the interferon response. This suggests that specific HERV groups may have the potential to trigger gene networks and influence viral immune responses. - Source: PubMed
Publication date: 2024/12/21
Liang WenStubbe MionaPleninger LisaHofferek AnnaStubbe HansMai JuliaÖzer SalihFrishman DmitrijSchreiner SabrinaVincendeau Michelle - Uterine corpus endometrial carcinoma (UCEC) is one of the most common types of cancer in women, and the incidence is rapidly increasing. Studies have shown that various signaling pathways serve crucial roles in the tumorigenesis of UCEC, amongst which the Wnt/β-catenin pathway is of great interest due to its crucial role in cell proliferation and the huge potential as a therapeutic target. In the present study, it was shown that FBXO17, which is a member of the F-box family, is abnormally downregulated in UCEC tissues compared with non-tumor endometrial tissues, and this was significantly associated with the clinical histological grade, as well as the abnormal proliferation of the UCEC cell line, Ishikawa, both and . Besides, the results suggested that FBXO17 may inhibit the Wnt/β-catenin signaling pathway and influence the expression of adhesion molecules, such as E-cadherin and N-cadherin in Ishikawa cells. In conclusion, these findings indicate that FBXO17 is a novel inhibitor of endometrial tumor development and it likely exerts effects via regulation of the Wnt signaling pathway. - Source: PubMed
Publication date: 2022/08/15
Zheng Zi-MengWang Ying-YingChen MinYang Hui-LiLai Zhen-ZhenLi Ming-QingShao Jun - Renal cell carcinoma (RCC) is a common lethal urological malignancy. Circular RNAs are assumed to play important roles in cancer development. The objective of the present study was to investigate the role and action mechanism of circ_0008717 in RCC. - Source: PubMed
Publication date: 2022/10/09
Shen SiyaoJiang MingDeng WenLiu XiaoqiangXiong JunhuiZeng ZhigangZhao HongZeng XiaochunFu Bin