Ask about this productRelated genes to: PRG3 antibody
- Gene:
- AIFM2 NIH gene
- Name:
- apoptosis inducing factor mitochondria associated 2
- Previous symbol:
- AMID
- Synonyms:
- FLJ14497, PRG3
- Chromosome:
- 10q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-20
- Date modifiied:
- 2019-01-18
- Gene:
- PRG3 NIH gene
- Name:
- proteoglycan 3, pro eosinophil major basic protein 2
- Previous symbol:
- -
- Synonyms:
- MBPH, MBP2
- Chromosome:
- 11q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2016-06-17
Related products to: PRG3 antibody
Related articles to: PRG3 antibody
- Ferroptosis is a multi-step regulated cell death that is characterized by excessive iron accumulation and lipid peroxidation. Cancer cells can acquire resistance to ferroptosis by the upregulation of anti-ferroptotic proteins or by the downregulation of pro-ferroptotic proteins. Apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also known as FSP1 or PRG3) has been recently demonstrated as an endogenous ferroptosis suppressor, but its mechanism remains obscure. Here, we show that AIFM2 blocks erastin-, sorafenib-, and RSL3-induced ferroptotic cancer cell death through a mechanism independent of ubiquinol, the reduced and active antioxidant form of coenzyme Q10. In contrast, AIFM2-dependent endosomal sorting complexes required for transport (ESCRT)-III recruitment in the plasma membrane is responsible for ferroptosis resistance through the activation of a membrane repair mechanism that regulates membrane budding and fission. Importantly, the genetic inhibition of the AIFM2-dependent ESCRT-III pathway increases the anticancer activity of sorafenib in a xenograft tumor mouse model. These findings shed new light on the mechanism involved in ferroptosis resistance during tumor therapy. - Source: PubMed
Publication date: 2020/01/18
Dai EnyongZhang WenlongCong DanKang RuiWang JingTang Daolin