Ask about this productRelated genes to: AXUD1 antibody
- Gene:
- CSRNP1 NIH gene
- Name:
- cysteine and serine rich nuclear protein 1
- Previous symbol:
- AXUD1
- Synonyms:
- URAX1, DKFZp566F164, FAM130B, TAIP-3
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-03
- Date modifiied:
- 2016-10-05
Related products to: AXUD1 antibody
Related articles to: AXUD1 antibody
- Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and chronic kidney disease, characterized by podocyte injury and glomerular scarring. Its heterogeneity complicates early diagnosis and treatment. - Source: PubMed
Publication date: 2026/03/24
Zhang JingkeNing HanHou YunTang Ning - The RNA-binding protein is involved in tumorigenesis. To systematically elucidate its pan-cancer role, we conducted an integrated analysis of across malignancies, combining bioinformatic exploration with experimental validation. Utilizing datasets from TCGA, GEO, GTEx, HPA, CPTAC, GEPIA2, TIMER2, cBioPortal, and STRING, we employed bioinformatics methods to investigate the potential carcinogenic properties of . This included examining correlations between and gene expression, prognosis, gene mutation, immunohistochemistry staining, immune cell infiltration, and constructing an interaction network of 50 -binding proteins. Additionally, we performed enrichment analysis of -related partners. Furthermore, to validate key bioinformatic predictions, quantitative real-time PCR (qRT-PCR) was performed on paired cancer/normal cell lines (LIHC, LUAD, BRCA). expression was found to be dysregulated in a cancer type-dependent manner, with significant upregulation observed in most tumor types analyzed, including BLCA, BRCA, LIHC, and LUAD. Furthermore, demonstrated early diagnostic value across 33 types of tumors and showed varying associations with prognosis depending on the tumor type. was also significantly associated with most immune-infiltrating cells in pan-cancer analyses. High expression was linked to pathways related to tumor progression. Critically, these bioinformatic predictions were experimentally validated, as qRT-PCR confirmed the significant upregulation of and its functional network genes (, , , ) in LIHC, LUAD, and BRCA cell lines. This study provides a comprehensive pan-cancer analysis of , integrating bioinformatics with experimental validation. We demonstrated its dysregulation across cancers in a type-dependent manner, correlations with immune infiltration and tumor-associated pathways. Critically, qRT-PCR experiments confirmed the significant co-upregulation of and its functional network genes (, , , ) in LIHC, LUAD, and BRCA cell lines. These findings establish as a promising diagnostic and prognostic biomarker and suggest its role as a pivotal post-transcriptional regulator in tumorigenesis, supporting its potential for clinical application in cancer assessment. - Source: PubMed
Publication date: 2026/03/08
Xie ShuyuanWu HuidanLi XuanwenWang BingyeLiu YuxuanLi CongyingHuang QingYang YangGu Shinong - Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study aimed to identify key genes involved in HCC development and elucidate their molecular mechanisms, with a particular focus on mitochondrial function and apoptosis. - Source: PubMed
Publication date: 2025/12/30
Shi HuihuiChen LeiHuang JuanLin XuejingHuang LeiTang MinLu KaiWang WenchaoZhu Maoling - In humans, vitamin D synthesis follows a day-night rhythm due to its UV-B-dependent production. - Source: PubMed
Publication date: 2025/03/29
Maissan ParcivalCarlberg Carsten - Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but not in individuals with APOL1 high-risk genotypes. We conducted an epigenome-wide analysis of CKD and estimated glomerular filtration rate (eGFR) in in people of African ancestry and APOL1 high-risk genotypes with HIV. - Source: PubMed
Hung Rachel K YCosteira RicardoChen JunyuSchlosser PascalGrundner-Culemann FranziskaBooth John WSharpe Claire CBramham KateSun Yan VMarconi Vincent CTeumer AlexanderWinkler Cheryl APost Frank ABell Jordana T