Ask about this productRelated genes to: GRIM19 antibody
- Gene:
- NDUFA13 NIH gene
- Name:
- NADH:ubiquinone oxidoreductase subunit A13
- Previous symbol:
- -
- Synonyms:
- CGI-39, CDA016, GRIM-19, GRIM19, B16.6
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-20
- Date modifiied:
- 2016-04-25
Related products to: GRIM19 antibody
Related articles to: GRIM19 antibody
- Advanced renal failure remains a major global health burden. Mitochondrial dysfunction is frequently observed during progressive kidney injury and chronic allograft dysfunction (CAD), but observational data cannot distinguish causal involvement from secondary consequences. We applied a multi-omic genetic prioritization framework to evaluate whether inherited variation affecting mitochondrial gene regulation is associated with a proxy phenotype for advanced renal failure and fibrotic allograft remodeling. - Source: PubMed
Publication date: 2026/03/27
Shen QinghuanDing RunminWen ZhiyuFeng DengyuanZhang JianjianLiu JiawenHan QianguangSun LiChen HaoFei ShuangXu ZhenHao RuijinlinTan Ruoyun - Intervertebral disc degeneration (IDD) is a common condition associated with aging and degeneration of the disc. Type 2 diabetes mellitus (T2DM) is linked to various musculoskeletal disorders, including IDD, but its molecular effects on IDD remain understudied. To explore the molecular differences in IDD between T2DM and non-T2DM patients, we conducted a quantitative proteomic analysis of nucleus pulposus (NP) tissues from patients with T2DM-IDD or non-T2DM-IDD individuals. We identified 3,720 proteins, with 221 significantly upregulated and 233 downregulated in T2DM-IDD. Multiple mitochondrial proteins were upregulated (NDUFV2, NDUFB5, NDUFA13, MPC2) indicating a potential increase in oxidative stress in the NP tissues from T2DM-IDD. Conversely, downregulated proteins such as versican (VCAN), an extracellular matrix proteoglycan, IL17B, a pro-inflammatory cytokine, and vascular endothelial growth factor A (VEGFA) indicate possible alterations in ECM composition and structure that impact the mechanical properties and integrity of the IVD as well as a reduced inflammatory response in NP tissues from non-T2DM-IDD. Additionally, T2DM-IDD showed enrichment in fatty acid metabolism pathways, while non-T2DM-IDD samples were enriched in epithelial mesenchymal transition and hypoxia pathways. Altogether, these results provide novel insights into the molecular mechanisms of T2DM-IDD and may guide future therapies. - Source: PubMed
Publication date: 2026/03/26
Moinuddin F MZhong JunAstudillo Potes Maria DDominari AsiminaDhar AshisPandey AkhileshBydon Mohamad - As a degenerative disease, the pathophysiology of intervertebral disc herniation (IDH) closely related to mitochondrial dysfunction. However, the specific molecular mechanisms involved have yet to be precisely established. - Source: PubMed
Publication date: 2026/02/14
Wang YihaoBie YongchenZhang YunHuang YingWu KailiMa XuexiaoLi Yan - Diabetic heart disease is marked by structural, functional, and molecular alterations in the myocardium. We investigated the effects of exercise training on oxidative phosphorylation-related genes in the diabetic heart. - Source: PubMed
Publication date: 2026/02/02
Shah Iqbal AliIshaq ShahidLee Shin-DaWu Bor-Tsang - Bisphenol A (BPA), a widespread environmental endocrine disruptor, has raised concerns for its neurotoxic effects, yet its molecular role in stroke remains unclear. - Source: PubMed
Publication date: 2025/12/27
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