Ask about this productRelated genes to: RanBP17 antibody
- Gene:
- RANBP17 NIH gene
- Name:
- RAN binding protein 17
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-22
- Date modifiied:
- 2016-10-05
Related products to: RanBP17 antibody
Related articles to: RanBP17 antibody
- Renal tubulocystic oncocytoma (RTO) is an exceptionally rare variant of renal oncocytoma (RO) with poorly understood genetic underpinnings. This study aimed to characterize the clinicopathological features and genomic landscape of RTO to enhance diagnostic precision and elucidate its molecular profile. - Source: PubMed
Publication date: 2026/04/14
Wang WenchiZhu HengxingChen ChunyuSun ManWang HonglongTai YuChen SishanLiu ZhuoFan BoLi Yinghua - Within feather pattern variation is widespread among chicken breeds globally and is primarily characterized by the distributions of eumelanin on a single feather vane. To analyze the genetic basis underlying different within feather patterns, we conducted the GWAS by pairwise comparing the three common patterns observed in Chinese domestic chickens: stippling, pencilling, and arrow. Based on the coding-region variants, a set of candidate genes were sifted out, notably MC1R, CDH1, MYO5C, FOXI2, and RANBP17, which are functionally associated with melanogenesis and pigment transport. From the perspective of regulatory variants, we integrated GWAS signals with RNA-seq data from growing-phase feather follicles to identify candidates driving transcript-level divergence. With putative regulatory variants, RANBP17, MAPK6, and LOC107051763 were identified as overlapping candidates with differentially expressed genes. Overall, by integrating coding-region and regulatory-region variant analysis, this study identified a set of prioritized candidate genes linked to within feather patterning. This study provides the first systematic genetic dissection of within-feather patterns in domestic chickens by integrating GWAS and RNA-seq, offering new insights into the genetic and developmental mechanisms underlying avian within feather pattern formation. - Source: PubMed
Publication date: 2026/02/14
Guo HuanjieChen YuqiGuo YifanWang BinghuiLi Jingyi - Drug-resistant tuberculosis (DR-TB) undermines global TB control, yet how resistant strains interact with the lung microbiome, phage communities, and local host immunity remains poorly defined. - Source: PubMed
Publication date: 2026/01/29
Zhang HaiqingZhang LimaoYang BinGao ChunjingLiu HuimeiZhang YunshiChen Xiaoyou - To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 controls. We identified four HCC-associated genes, including NRDE2, RANBP17, RTEL1, and STEAP3. Using NRDE2 (index rs199890497 [p.N377I], p = 1.19 × 10) as an exemplary candidate, we demonstrated that it promotes homologous recombination (HR) repair and suppresses HCC. Mechanistically, NRDE2 binds to the subunits of casein kinase 2 (CK2) and facilitates the assembly and activity of the CK2 holoenzyme. This NRDE2-mediated enhancement of CK2 activity increases the phosphorylation of MDC1 and then facilitates the HR repair. These functions are eliminated almost completely by the NRDE2-p.N377I variant, which sensitizes the HCC cells to poly(ADP-ribose) polymerase (PARP) inhibitors, especially when combined with chemotherapy. Collectively, our findings highlight the relevance of the rare variants to genetic susceptibility to HCC, which would be helpful for the precise treatment of this malignancy. - Source: PubMed
Publication date: 2024/05/01
Wang YahuiLiu XinyiZuo XianboWang CuilingZhang ZhengZhang HaitaoZeng TaoChen ShunqiLiu MengyuChen HongxiaSong QingfengLi QiYang ChenningLe YiXing JinliangZhang HongxinAn JiazeJia WeihuaKang LongliZhang HongxingXie HuiYe JiazhouWu TianzhunHe FuchuZhang XuejunLi YuanfengZhou Gangqiao - DYT1 dystonia is a debilitating neurological movement disorder, and it represents the most frequent and severe form of hereditary primary dystonia. There is currently no cure for this disease due to its unclear pathogenesis. In our previous study utilizing patient-specific motor neurons (MNs), we identified distinct cellular deficits associated with the disease, including a deformed nucleus, disrupted neurodevelopment, and compromised nucleocytoplasmic transport (NCT) functions. However, the precise molecular mechanisms underlying these cellular impairments have remained elusive. In this study, we revealed the genome-wide changes in gene expression in DYT1 MNs through transcriptomic analysis. We found that those dysregulated genes are intricately involved in neurodevelopment and various biological processes. Interestingly, we identified that the expression level of RANBP17, a RAN-binding protein crucial for NCT regulation, exhibited a significant reduction in DYT1 MNs. By manipulating RANBP17 expression, we further demonstrated that RANBP17 plays an important role in facilitating the nuclear transport of both protein and transcript cargos in induced human neurons. Excitingly, the overexpression of RANBP17 emerged as a substantial mitigating factor, effectively restoring impaired NCT activity and rescuing neurodevelopmental deficits observed in DYT1 MNs. These findings shed light on the intricate molecular underpinnings of impaired NCT in DYT1 neurons and provide novel insights into the pathophysiology of DYT1 dystonia, potentially leading to the development of innovative treatment strategies. - Source: PubMed
Publication date: 2024/04/10
Akter MasumaCui HaochenHosain Md AbirLiu JinmeiDuan YuntianDing Baojin