Ask about this productRelated genes to: UCP3 Blocking Peptide
- Gene:
- UCP3 NIH gene
- Name:
- uncoupling protein 3
- Previous symbol:
- -
- Synonyms:
- SLC25A9
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-11
- Date modifiied:
- 2016-04-28
Related products to: UCP3 Blocking Peptide
Related articles to: UCP3 Blocking Peptide
- : The aim of this pilot study was to evaluate the hierarchical contribution of individual genetic polymorphisms to the variability of autonomic regulation parameters and respiratory function in athletes of different sport specializations using Classification and Regression Tree (CRT) analysis. : The study included athletes divided into two groups: hockey players ( = 48) and martial artists ( = 43). Heart rate variability (LF, HF) parameters and spirometric indices (FEV) were assessed. Genetic analysis included 8 single nucleotide polymorphisms (SNPs): IL6 rs1800795, VDR rs731236, KCNJ11 rs5219, ADRB2 rs1042713, ADRB2 rs1042714, TRHR rs16892496, MSTN rs1805086, UCP3 rs1800849. : In martial artists, the main predictors were genes responsible for adrenoreceptor sensitivity (ADRB2) and neuroimmune interactions (IL6). In hockey players, the most significant predictors were genes involved in muscle growth (MSTN), energy metabolism (UCP3), and neuroendocrine regulation (TRHR). These findings indicate that similar resting HRV parameters in athletes from different sports may be associated with different genetic polymorphisms, reflecting sport-specific physiological adaptations to training loads. : The results highlight the sport-specific nature of genetic determinants of autonomic regulation. In martial artists, genes related to the immuno-adrenergic axis (IL6, ADRB2) appear to play a dominant role, whereas in hockey players neuroendocrine, muscle-metabolic, and mitochondrial factors (TRHR, MSTN, UCP3) demonstrate greater influence. The observed interactions between genotypes and FEV emphasize the importance of transitioning from generalized approaches toward personalized monitoring strategies in sports science. - Source: PubMed
Publication date: 2026/04/21
Bacheva IrinaIbrayeva LyazatRybalkina DinaKadyrova IrinaZhumagaliyeva Diana - Main risk factors associated with the development of sarcopenia (coexistence of muscle mass loss and dysfunction) are a sedentary lifestyle coupled with obesity. Associated mitochondrial dysfunction leads to energy deficits and perturbations in the balance between protein synthesis and degradation, thereby triggering muscle dysfunction or atrophy. Aside from exercise, which is challenging to implement and maintain, particularly in women, treatments for diminishing sarcopenia are scarce. The objective of the present study was to evaluate the effect of the flavanol (-)-epicatechin (EC) in a hypercaloric diet-induced obese female rat model. Muscle strength and endurance, as well as relative mitochondrial DNA content in skeletal muscle, were assessed. - Source: PubMed
Publication date: 2026/03/22
Herrera-Cogco Elena de la CHerrera-Meza SocorroMartínez-Meza YuridiaPérez-Durán JavierCeballos GuillermoMéndez-Bolaina EnriqueNájera Nayelli - Cisplatin is an effective chemotherapeutic agent, yet its clinical utility is limited by dose-dependent nephrotoxicity. Alpha-1 antitrypsin (AAT) has cytoprotective, anti-inflammatory, and antiapoptotic properties, but its therapeutic potential in cisplatin-induced acute kidney injury (AKI) remains unclear. A murine cisplatin-AKI model was used to evaluate whether AAT (80 mg/kg) ameliorates renal injury. Renal function, oxidative stress, NADPH oxidase (NOX) isoforms, mitochondrial metabolism, inflammatory mediators, apoptosis, and fibrosis-related markers were assessed using biochemical, histological, immunohistochemical, and Western blot analyses. Cisplatin markedly impaired renal function and induced tubular injury; meanwhile, AAT significantly reversed these changes. Cisplatin also induced severe oxidative stress and disrupted the balance of NOX isoforms; AAT restored redox homeostasis. Cisplatin upregulated CPT1A/PDK4 and suppressed CPT2, UCP3, PGC1α, and DRP1, inducing maladaptive mitochondrial changes, indicating impaired β-oxidation and defective mitochondrial dynamics; AAT reversed these alterations, restoring normal mitochondrial metabolism. IL-1β, IL-6R, OPN, and F4/80 expression, recovery of the Bax/Bcl-2 ratio, and MAPK activation were reduced, indicating decreased inflammation and apoptosis; profibrotic markers were also reduced. AAT confers multifaceted protection against cisplatin-induced AKI by restoring redox balance, mitochondrial homeostasis, and inflammatory and apoptotic signaling. These findings support AAT as a promising therapeutic agent for preventing cisplatin nephrotoxicity. - Source: PubMed
Publication date: 2026/02/02
Kim MinaOh Se-HyunHan JinAhn Ji-SunOh Eun-JooJung Hee-YeonChoi Ji-YoungCho Jang-HeePark Sun-HeeKim Chan-DuckKim Yong-LimJeon You HyunLim Jeong-Hoon - With the ongoing upgrade in consumption patterns, the pork market is shifting from a focus on quantity to an emphasis on quality, demanding higher intramuscular fat content alongside maintained growth rates. Crossbreeding between the Chinese lean-type Songliao black pig and the high-quality local breed Leixiang pig allows rapid integration of parental superior traits, resulting in hybrid vigor that effectively improves pork quality, growth performance, and economic benefits. We conducted transcriptomic and 4D microDIA proteomic sequencing analyses on the muscle tissue from hybrid offspring of purebred Songliao black pigs and Songliao × Leixiang black pigs. Extensive phenotypic analyses were performed on Songliao black pigs and Songlei black pigs using multiple trait indicators. Six pigs were selected and categorized into relatively high and low intramuscular fat groups. Integrated analysis of transcriptomic and proteomic data identified candidate genes within significantly annotated lipid-related pathways via KEGG, including , , , , , , , and . Among these, was significantly associated with fatty acid metabolism pathways. By analyzing all significantly differential genes and proteins, six candidate genes were identified as key determinants of genetic variation in lipid deposition: , , , , , and . This preliminary exploratory multi-omics study provides a valuable resource for probing intramuscular fat deposition, aiming to support pork-trait improvement in breeding and to establish a fresh theoretical basis for clarifying the molecular mechanisms of meat-quality heterosis in Songlei black pigs. - Source: PubMed
Publication date: 2026/01/29
Zhang YunpengZhang QiKumar Suthar TeerathXu JingXie YupengWang ZhihaoSun Wu-ShengPan LiZhao YuanZhang Shu-Min - The rising incidence of cancer has demanded the development of new anti-cancer chemical sources. The presence of phenolics in hazelnut cell cultures has led to the development of new and potential pharmacotherapeutic uses. Hazelnut extract has emerged as a promising candidate due to its high phytochemical content. HCT-116 colorectal cancer IC cell viability of Palaz and Tombul hazelnut extracts was determined as 400 μg/mL and 200 μg/mL, respectively. Flow cytometry annexin V-fluorescein isothiocyante (FITC) apoptosis detection indicated apoptosis of Tombul hazelnut extract and Palaz hazelnut extract as 23.53% and 17.47%, respectively. The apoptosis result of flow cytometry was also supported at the protein level. Hazelnut extracts resulted in an increased loss of MMP as well. The loss of MMP has significantly increased from an average of 0.61% to 16.17% in Tombul hazelnut extract and to 20.38% in Palaz hazelnut extract. This is further supported by screening , and gene expressions. Targeting apoptosis pathways, particularly MMP, is an effective strategy for cancer prevention and treatment. Hazelnut extract contains phenolic compounds, which activate these pathways, resulting in enhanced apoptosis in colorectal cancer cells. The phenolic contents of Palaz and Tombul hazelnut extracts were determined as 271.72 ± 5.3 mg gallic acid equivalent (GAE)/100 g sample dry weight (DW) and 85.23 ± 2.2 mg GAE/100 g sample DW, respectively. Further, hazelnut extract may reduce oxidative stress, contributing to its anti-cancer properties. The extracts could be utilized as functional ingredients in foods and nutraceuticals to assist with cancer prevention and treatment. - Source: PubMed
Publication date: 2025/12/19
Bayram BanuDemircan EvrenKarimidastjerd AtefehAkyüz Elvan YılmazTutar Yusuf