Ask about this productRelated genes to: TIE2 antibody
- Gene:
- TEK NIH gene
- Name:
- TEK receptor tyrosine kinase
- Previous symbol:
- VMCM
- Synonyms:
- TIE2, TIE-2, VMCM1, CD202b
- Chromosome:
- 9p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2018-08-07
Related products to: TIE2 antibody
Related articles to: TIE2 antibody
- Opioid use disorder is a chronic relapsing condition with major global public health impacts. Despite rising opioid use and overdose rates, data availability remains uneven, limiting understanding of treatment and harm reduction services worldwide. This study aims to provide a global overview of current practices in treatment and harm reduction for opioid use disorder. - Source: PubMed
Publication date: 2026/08/17
Khojasteh Zonoozi ArashAbolghasemi Fateme SadatAhmadi PooriaBisch MichaëlButner Jenna LChow Kim Weng DrConti Aldo AlbertoDanesh AhmadEbrahimi MohsenEl-Khoury JosephFarhoudian AliJouzdani Ali FathiGuterstam JoarHernández María Del MilagroJokūbonis DariusKathiresan PreethyKrupitsky Evgeny MLee Seung-YupLong JiangMaremmani IcroMiovský MichalMooney LarissaNielsen SuzanneRafei ParnianRodgers CraigRúnarsdóttir ValgerðurSevarino Kevin ASomaini LorenzoVista Salvador Benjamin DimayaVossenberg PeterWojnar MarcinYee AnneZare-Bidoky MehranAmbekar AtulBaldacchino AlexPotenza Marc NEkhtiari Hamed - Remote ischemic conditioning (RIC) is a non-invasive strategy that mitigates ischemic injury, partly through circulating microRNAs. Emerging evidence suggests that miRNAs may modulate angiogenesis, which is essential for post-stroke recovery. This study investigated the effect of four RIC-induced miRNAs (RIC-miRNAs), miR-16-5p, miR-144-3p, miR-182-5p, and miR-451a, in immortalized human brain microvascular endothelial cells (IM-HBMECs) exposed to inflammatory conditions in vitro. Transcriptomic and in silico analysis were used to identify target genes of RIC-miRNAs. Two angiogenesis-related genes, SLIT2 and TEK, were validated in vitro as functional targets of miR-16-5p and miR-144-3p, respectively. Functional enrichment analysis further linked the RIC-miRNA-associated targets to the regulation of apoptotic processes, cytokine production, and sprouting angiogenesis. These findings suggest that miR-16-5p and miR-144-3p may modulate endothelial pathways involved in cell death, inflammatory signaling, and vascular remodeling during the response to stroke. - Source: PubMed
Publication date: 2026/08/15
Marziani LaraStenz Katrine TangZhang HaoZhao WeixiangMumm Birgitte HviidDong-Fang XieWang MinxianWang Xiu-JieDrasbek Kim Ryun - Loneliness has been repeatedly linked to adolescents' exposure to online risks. However, the psychological mechanisms linking loneliness to online child sexual victimization remain insufficiently understood. - Source: PubMed
Publication date: 2026/08/14
Normand-Pascual EnriquePérez-García José ManuelParrado-González AlbertoTesta GiuliaVillena-Moya AlejandroChiclana-Actis CarlosFernández-Aranda FernandoPotenza Marc NBőthe BeátaJiménez-Murcia SusanaMestre-Bach Gemma - TIE2 is an endothelial receptor tyrosine kinase (RTK) essential for vascular integrity, and constitutively active TIE2 mutants are involved in venous malformations (VMs). VMs are currently treated by surgery or sclerotherapy, but effective pharmacologic options remain limited, especially for surgically challenging Blue Rubber Bleb Nevus Syndrome (BRBNS). TIE2 activation has typically been assessed by immunoblotting of phosphoproteins, yet scalable assays applicable to pharmacological evaluation are still lacking. Here, we present a bioluminescence resonance energy transfer (BRET) biosensor that quantifies receptor-proximal TIE2 activation by monitoring recruitment of GRB2, a major adaptor in RTK signaling. This BRET sensor detects angiopoietin-1 (ANG-1) at physiological plasma concentrations and is compatible with a high-throughput format. Furthermore, it captures constitutive activity of TIE2 mutants associated with VMs and enables pharmacological evaluation of TIE2 variants. Notably, the T1105N-T1106P variant, frequently observed in BRBNS, exhibited relatively higher sensitivity to the clinical oncology drugs regorafenib and lenvatinib. To validate selected BRET-defined pharmacological profiles in an endothelial context, we used HUVEC-derived HUEhT-2 cells and established endothelial TIE2-GRB2 BRET measurements, followed by downstream AKT/ERK signaling analysis and tube formation assays. These endothelial assays largely supported the selected HEK293T BRET findings, particularly the pharmacological profile of T1105N-T1106P mutant, at receptor-proximal, downstream signaling, and functional levels. Together, this BRET-based biosensor establishes a two-step framework: HEK293T BRET enables efficient primary profiling, whereas endothelial assays provide orthogonal validation to support biological interpretation. This framework offers a practical strategy for prioritizing pharmacological candidates for further endothelial and in vivo validation toward therapeutic development. - Source: PubMed
Publication date: 2026/08/13
Matsutani HitomiOishi AtsuroIzumi-Tamura TakuyaHayashi YumikoKurita MasakazuMuto TomoyaYoshimi AkihideUeno HitoshiShiraishi TomohiroHarii KiyonoriTakushima AkihikoKidoya HiroyasuOzaki Mine - Gallstone ileus (GSI) is a rare surgical emergency. Its diagnosis is challenging and frequently delayed. Moreover, there is no consensus regarding the optimal surgical approach. The primary point of debate is whether cholecystectomy and fistula repair should be performed and, if so, when. Several studies have suggested that omitting cholecystectomy and fistula repair may increase the risk of cholangitis, gallbladder cancer, and recurrent gallstone ileus. However, most of these data originate from studies conducted in the previous century and have not been supported by contemporary evidence. This study aimed to present our clinical experience with gallstone ileus, discuss diagnostic and therapeutic strategies, and review the relevant literature. - Source: PubMed
Feratoğlu FatihHacıalioğlu CemalYılmaz Tarık EmreKaya Selçuk