RANTES Synthetic Protein
- Known as:
- RANTES Synthetic Protein
- Catalog number:
- x1248c
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Exalpha
- Gene target:
- RANTES Synthetic Protein
Related genes to: RANTES Synthetic Protein
- Gene:
- CCL5 NIH gene
- Name:
- C-C motif chemokine ligand 5
- Previous symbol:
- D17S136E, SCYA5
- Synonyms:
- RANTES, SISd, TCP228, MGC17164
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-05
- Date modifiied:
- 2016-03-01
Related products to: RANTES Synthetic Protein
Related articles to: RANTES Synthetic Protein
- Asthma is a complex, heterogeneous, and inflammatory disease with an increasing incidence worldwide. This study aimed to investigate the therapeutic mechanisms of sophocarpine in asthma systematically. - Source: PubMed
Publication date: 2026/08/24
Zhi WenbingZhang HongQiao ZiyaoJiang ShengnanLiang ZongsuoLiu Yang - Fine particulate matter (PM) and metabolic dysfunction-associated steatotic liver disease (MASLD) are independent risk factors for respiratory disease. However, the combined impact of chronic, low-dose PM exposure and Western diet (WD)-induced metabolic dysfunction on pulmonary health remains poorly understood. We investigated whether this metabolic state exacerbates PM-driven pathologies using an environmentally relevant PM dosage (~50 μg/m). - Source: PubMed
VAN Tran Tran ThiChen Yi-SiaoChen Yi-TingLiu Yu-WeiChen I-ChenYen Chia-Hung - Tay-Sachs disease (TSD) is a fatal lysosomal storage disorder characterized by neuronal GM2 ganglioside accumulation and progressive neurodegeneration. Neuroinflammation and oxidative stress are increasingly seen as key factors in disease progression. In this study, we evaluated the effects of istradefylline, a selective adenosine A2A receptor antagonist, in the Hexa-/-Neu3-/- mouse model, which closely recapitulates the neuropathological features of human TSD. Istradefylline treatment reduced the expression of several proinflammatory markers, including Ccl2, Ccl3, Ccl5, Cxcl10, Il1b, and Gfap, particularly in the cortex. Immunohistochemical analysis indicated reduced astrogliosis and microgliosis and increased CNPase-positive oligodendrocytes following treatment. The two-phase regimen also modulated antioxidant-response gene expression, including Sod2, Catalase, and Ttase1, and increased cortical APE1 protein abundance. Behavioral assessment demonstrated improved rotarod performance, particularly following two-stage treatment, whereas the open-field findings did not support a significant effect on anxiety-like behavior or locomotor activity. Istradefylline did not substantially reduce GM2 accumulation or restore neuronal density, indicating that it did not correct the primary storage pathology or prevent associated neuronal loss. Overall, istradefylline attenuated selected neuroinflammatory and glial alterations and modulated antioxidant-response markers in Hexa-/-Neu3-/- mice. These findings support further investigation of A2A receptor antagonism as an adjunctive symptomatic and anti-inflammatory strategy, potentially in combination with treatments that directly target the underlying enzymatic deficiency. - Source: PubMed
Publication date: 2026/08/27
Ates NurselinSeyrantepe Volkan - Most patients with solid tumors do not respond to immune checkpoint blockade, and inadequate T cell infiltration of the tumor parenchyma is the dominant mechanism of primary resistance. Oncolytic viruses address this problem by a distinct route: they replicate selectively within tumor cells, produce immunogenic cell death, and convert infected cells into local sources of any encoded transgene. Most armed designs to date have carried cytokine or checkpoint-antibody payloads, and chemokines have attracted comparatively little attention despite bearing directly on the trafficking bottleneck. This review synthesizes the preclinical literature on chemokine-armed oncolytic viruses across three receptor axes: CXCR3 (CXCL9, CXCL10, CXCL11), CCR5 (CCL5/RANTES), and CCR7 (CCL19). The accumulated evidence indicates that therapeutic outcome depends less on the chemokine payload itself than on the interaction between payload and viral backbone. CXCL11 outperforms its sister CXCR3 ligands not through intrinsic potency but because it is non-redundant with the endogenous chemokines induced by vesicular stomatitis virus and vaccinia, and because it largely escapes proteolytic cleavage by dipeptidyl peptidase 4 (DPP4). CCL5 has shown the most consistent activity in dual-payload designs that pair chemotaxis with a T cell survival cytokine such as IL-15. CCL19, which addresses lymphoid organization rather than effector recruitment, rests on a single published construct. One evidence gap is central: no head-to-head comparison of chemokine payloads within a single viral platform has been published. We therefore propose a translational decision framework that aligns chemokine selection with the immune contexture of the target tumor. - Source: PubMed
Publication date: 2026/07/31
Alwithenani Akram - Heme oxygenase-1 (HO-1), encoded by , catalyzes the rate-limiting step of heme degradation and generates biliverdin, carbon monoxide, and ferrous iron, thereby linking heme turnover with redox regulation and stress-associated signaling. In birds, biliverdin is retained as a major heme-derived product, but the cellular consequences of perturbation remain insufficiently defined. Here, CRISPR/Cas9-mediated editing was used to generate a heterogeneous -edited population in Chicken hepatocellular carcinoma-derived cells. The selected sgRNA reduced HO-1 protein abundance by approximately 47%, and no detectable cleavage was observed at the seven predicted high-risk off-target loci examined. Compared with vector-control cells, -edited cells exhibited intracellular heme accumulation, reduced biliverdin levels, increased oxidation-sensitive fluorescence, and reduced CCK-8 absorbance values, indicating disruption of heme-biliverdin metabolic and redox homeostasis. RNA sequencing identified 2650 differentially expressed genes, including 951 upregulated and 1699 downregulated genes. Downregulated genes were mainly enriched in immune, cytokine, MAPK/stress, and extracellular signaling-associated pathways, whereas DNA replication and cell-cycle-related genes were increased. Enrichment-term association and STRING functional-association analyses further identified a coordinated module involving , , , , , , , and . Independent RT-qPCR analysis confirmed selected expression trends. These findings show that heterogeneous editing and reduced HO-1 abundance are associated with disruption of the avian heme-biliverdin metabolic axis and coordinated remodeling of basal immune, stress, extracellular signaling, and cell-cycle-associated transcriptional programs in Chicken hepatocellular carcinoma-derived cells. - Source: PubMed
Publication date: 2026/08/08
Tang HaonanLi HuaiyuTai YurongYang XueZhang LetianMa YuhaoCai GanxianZhao HongyangZeng TongAi XiaohuaHe ShuangWang JiankuiGu ZhiliangDeng Xuemei