Human uncoupling protein 1, UCP1 ELISA Kit
- Known as:
- Human uncoupling protein 1, UCP1 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 201-12-2173
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sunredbio SunBT Sun red bio
- Gene target:
- Human uncoupling protein 1 UCP1 ELISA Kit
Related genes to: Human uncoupling protein 1, UCP1 ELISA Kit
- Gene:
- UCP1 NIH gene
- Name:
- uncoupling protein 1
- Previous symbol:
- UCP
- Synonyms:
- SLC25A7
- Chromosome:
- 4q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-04-28
Related products to: Human uncoupling protein 1, UCP1 ELISA Kit
Related articles to: Human uncoupling protein 1, UCP1 ELISA Kit
- TRPA1 channels function as cold sensors and have been implicated in energy metabolism. We investigated the impact of TRPA1 on thermoregulation. mice exhibited body weight loss and increased food intake when transitioning from 30°C to mild cold (14 days at 22°C), indicating increased energy metabolism in response to cold. mice exhibited elevated oxygen consumption, while their core temperature remained unaffected. The BAT proteome in WT mice after 14 days at 22°C showed increased proteins related to glucose utilization and reduced proteins related to lipolysis, whereas mice revealed increased PRDM16 and proteins associated with peroxisomal/mitochondrial β-oxidation. Transcripts of , and were higher in mice at 22°C compared to 30°C, relative to WT mice, with expression uniquely increased in mice. Thermographic images revealed higher interscapular surface temperature in mice exposed to 22°C. These data suggest that the TRPA1 channel reduces metabolic stress and contributes to thermogenic regulation in mice. - Source: PubMed
Publication date: 2026/08/07
Sua-Cespedes Cristhian DLima Otoniel GonçalvesVasconcelos Letícia MenezesZanetti GiovannaAvelino da Silva MirianeMoraes Maria NathaliaGomes GuilhermeFestuccia William TadeuCastrucci Ana Maria LLacerda José Thalles - Employing a dual strategy combining Small Molecule Accurate Recognition Technology and bioactivity-guided approaches, the roots of Edgeworthia gardneri were investigated for the first time, leading to the isolation of seventeen previously unreported guaiane-type sesquiterpenoids, edgewolides A-Q (1-17), together with one known analogue (18). Notably, compounds 2 and 3 incorporate an unusual endoperoxide bridge, forging a 7,8-dioxabicyclo[4.2.1]nonane and a 6,7-dioxabicyclo[3.2.2]nonane scaffold, respectively. Their structures were elucidated through comprehensive spectroscopic analyses, single-crystal X-ray diffraction, and quantum chemical calculations. Anti-adipogenic screening revealed that eight members attenuated lipid accumulation in differentiated 3T3-L1 adipocytes, with 2 exhibiting the highest potency. Structure-activity relationships pinpoint an α-substituted acrolein moiety appears to be critical for activity. Preliminary mechanistic studies indicated that 2 promotes lipolysis via HSL activation and boosts thermogenesis by up-regulating UCP1 and PGC-1α. - Source: PubMed
Publication date: 2026/08/14
Yang Ming-CuiTian Lin-LinSong Xiu-QingFan Yao-Yue - The global obesity epidemic and associated metabolic comorbidities have imposed an insurmountable strain on healthcare systems, underscoring the urgent need for simple, early interventions to curb obesity at its onset. To address this problem, we developed a novel solid beverage RLMCR (Chinese National Invention Patent No. ZL 202410541939.2) and proved its therapeutic effects on established obesity, yet its preventive potential and underlying mechanisms remain unelucidated. - Source: PubMed
Publication date: 2026/07/30
Wen YingPeng Yan-MeiZhou Xuan-YuWu Hui-XuanTang Chen-YiCheng FeiHan Yu-XinJiang Hong-LiGong ZhuoBu Yan-HongLi LongXiao FenCai Jun-MinMo Yu-YaoYang QianChen Heng-LeZhan Cong-YingZhou Hou-De - Sphingosine-1-phosphate (S1P) signaling has emerged as a regulator of metabolic homeostasis, but its relationship to brown adipose tissue (BAT) adaptation across physiological conditions remains unclear. We examined how S1P-related gene expression in BAT and subcutaneous white adipose tissue (scWAT) varies with acute exercise, chronic exercise, ambient temperature, aging, sex, and UCP1 deficiency. Young and aged wild-type mice, as well as aged UCP1 knockout (UCP1KO) mice, were studied across acute or chronic exercise paradigms and thermal conditions ranging from 4 °C to 30 °C. In BAT, acute exercise was associated with lower , , and expression in young females, whereas aged males showed lower and after exercise. In scWAT, exercise-associated induction of S1P-related transcripts was most evident in aged males. Female BAT also displayed broader temperature- and chronic exercise-associated differences in , , and β-adrenergic receptor transcripts, whereas male BAT showed fewer transcriptional changes. In UCP1KO mice, these exercise-associated patterns were altered or attenuated. Together, these findings identify a context-dependent adipose S1P-related transcriptional program that differs by sex, age, depot, ambient temperature, exercise condition, and UCP1 status. - Source: PubMed
Publication date: 2026/07/27
Ozabrahamyan SerenaNirengi ShinsukeVidal PabloBaer Lisa AStanford Kristin I - Childhood obesity may be associated with an accelerated loss of thermogenic adipocytes, increasing the risk of progressive lipid accumulation and metabolic deterioration. Early detection of the loss of thermogenic adipocytes would allow improved intervention to abrogate childhood obesity, yet reliable markers of human thermogenic adipocytes remain limited. We previously identified expression of (family with sequence similarity 153 member A) in the developing human adipose tissue. Here, we investigated the expression pattern and potential association of with the thermogenic transcriptional program in the adipose tissue of infants, children, and adolescents. We found that adipocyte expression was triggered by beta adrenergic receptor stimulation, a key signal of adipocyte thermogenesis. protein was confined to preadipocyte and adipocyte nuclei, and mRNA expression positively correlated with the mRNA levels of canonical thermogenic adipocyte markers including uncoupling protein 1 (), myogenic differentiation 1 (), type II iodothyronine deiodinase (), transmembrane protein 26 (), Lim Homeobox 8 (), beta adrenergic receptor 2 (), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (). Importantly, expression was positively associated not only with the expression of individual thermogenic genes but also with their coordinated co-expression. Collectively, our findings identify as a novel mRNA biomarker of human thermogenic adipocytes that serves as a robust indicator of the thermogenic transcriptional network. - Source: PubMed
Publication date: 2026/07/24
Gyurina KatalinKorpás Kristóf LeventeBajusz-Rácz AnitaRadványi ÁdámSasi-Szabó LászlóMéhes GáborRöszer Tamás