Human Mucin-4,MUC4 ELISA Kit
- Known as:
- Human Mucin-4,MUC4 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 201-12-1941
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sunredbio SunBT Sun red bio
- Gene target:
- Human Mucin-4 MUC4 ELISA Kit
Related genes to: Human Mucin-4,MUC4 ELISA Kit
- Gene:
- MUC4 NIH gene
- Name:
- mucin 4, cell surface associated
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q29
- Locus Type:
- gene with protein product
- Date approved:
- 1991-05-22
- Date modifiied:
- 2014-11-18
Related products to: Human Mucin-4,MUC4 ELISA Kit
Related articles to: Human Mucin-4,MUC4 ELISA Kit
- Cervical cancer (CC) is one of the leading malignancies impacting women worldwide, with a large number of cases occurring in developing countries. However, there is a need for optimal predictive models that can precisely forecast the prognosis and guide treatment selection. Programmed cell death (PCD) and immune responses (IRs) are pivotal in understanding disease progression, diagnosis, therapeutic decision-making, and risk stratification, making them promising prognostic markers. In this study, machine learning approaches were applied to identify key prognostic genes related to PCD and IR, which led to the development of three prognostic models: a PCD index, an IR index, and a combined immune-cell death index (ICDI). The PCD and IR indices showed a positive correlation in risk scores, and all three models demonstrated comparable prognostic significance. Given the biological relevance of the immune and cell death pathways, we further investigated the ICDI derived from the key genes FADD, MUC4, CLNK, and CD8B. This analysis included validation against clinical parameters, nomograms, and exploration of immune infiltration. Profiling of drug susceptibility revealed that the high-risk cohort of patients showed resistance to rapamycin and idelalisib but were sensitive to thapsigargin and linsitinib. Overall, the ICDI shows strong potential as a prognostic marker for forecasting clinical outcomes and could facilitate personalized treatment strategies for CC patients. - Source: PubMed
Publication date: 2026/07/06
Kiruba BlessySundararajan Vino - Dry eye disease (DED) is a multifactorial ocular surface disorder characterized by tear film instability, inflammation, and epithelial injury, leading to discomfort and visual disturbance. Current treatments remain limited in efficacy and safety. A heparin-like glycosaminoglycan purified from the snail mucus of Achatina fulica (AFG) exhibits potential regenerative and anti-inflammatory properties. This study aimed to evaluate the therapeutic effectiveness and mechanism of AFG in DED. - Source: PubMed
Publication date: 2026/07/21
Ou ShangkunZhang LingliLin LishaZhang LiyingJiang HaoLong QiurongZhang MengZheng XueerTian XiaoyuWu YimingWu MingyiGu Hao - Secretory carcinoma of the breast (SCB) is an extremely rare malignant neoplasm, accounting for less than 0.15% of all breast carcinomas. It is characterized by distinctive secretory activity, a frequently triple-negative immunophenotype, and recurrent ETV6-NTRK3 fusion (1-3). - Source: PubMed
Publication date: 2026/07/02
Sun XiaoyuLiu Jiaqi - Pancreatic ductal adenocarcinoma (PDAC) exhibits diverse phenotypes, including epithelial and mesenchymal characteristics, yet these features have not been effectively translated into clinical applications. Mucins are implicated in tumor progression and therapeutic resistance and are considered potential diagnostic and therapeutic targets. In this study, five epithelial and three mesenchymal PDAC cell lines were cultured under two-dimensional (2D) and three-dimensional (3D) conditions to investigate mucin expression. Proteomic analysis identified five mucins (MUC1, MUC4, MUC5B, MUC19, and MUC20) in 2D culture and eight (including MUC2, MUC5AC, and MUC13) in 3D culture. Candidate mucins were further validated by immunocytochemistry with H-score assessment. MUC1 was consistently expressed in all PDAC cell lines and showed marked upregulation in several lines under 3D culture. In mesenchymal PDAC cell lines, mucin expression was largely restricted to MUC1, whereas epithelial lines displayed broad 3D-induced reorganization. Notably, MUC5AC was absent in 2D culture but robustly induced in all epithelial PDAC cell lines under 3D conditions. Other mucins, including MUC2, MUC4, MUC5B, MUC13, MUC19, and MUC20, were variably upregulated, with epithelial lines demonstrating higher diversity and intensity of expression. These findings demonstrate that 3D culture effectively reveals the plasticity and heterogeneity of mucin expression in PDAC, highlighting its potential as a platform for biomarker discovery and the development of therapeutic strategies. - Source: PubMed
Publication date: 2026/07/16
Shichi YuukiTsumoto HirokiFujiwara MasakazuNonaka KeisukeHasegawa YasukoShinji SeiichiRokutan HirofumiTakahashi KimimasaArai TomioMiura YuriIshiwata Toshiyuki - Acute hepatopancreatic necrosis disease (AHPND), caused by , poses a severe threat to global shrimp aquaculture. Reduced susceptibility of aquaculture-associated bacterial pathogens to conventional antibiotics, together with concerns regarding antimicrobial input and environmental exposure, highlights the need for dose-sparing therapeutic strategies. This study investigated the antibiotic-potentiating activity of honokiol (HKL), a plant-derived lignan, in combination with sulfamonomethoxine sodium (SMM-Na) against AHPND. Checkerboard and time-kill assays demonstrated that sub-inhibitory HKL concentrations (32-64 μg/mL) markedly enhanced SMM-Na activity, reducing its minimum inhibitory concentration by 8-32-fold and achieving bactericidal effects in combination. The SMM-Na + HKL combination also significantly inhibited biofilm formation and compromised bacterial membrane integrity, as evidenced by enhanced propidium iodide uptake and scanning electron microscopy, while inducing severe ATP depletion. In challenged with , dietary administration of low-dose SMM-Na (16 mg/kg) and HKL (32 mg/kg) yielded the highest survival rate (86.6%), substantially reduced hepatopancreatic bacterial load, attenuated histopathological damage, and restored total hemocyte counts. The treatment also upregulated a broad spectrum of immune-related genes (e.g., , , , , , ) in the hepatopancreas and mucosal barrier genes (e.g., , , , ) in the intestine. Furthermore, 16S rRNA sequencing indicated that the combination therapy was associated with treatment-related shifts in the intestine microbiota, including increased alpha diversity indices, reduced abundance, and altered predicted KEGG functional profiles. Collectively, our results identify HKL as a natural-origin antibiotic potentiator that enhances the efficacy of low-dose SMM-Na against AHPND-causing . These findings provide proof-of-concept evidence for a dose-sparing combination strategy that may reduce therapeutic SMM-Na input while supporting pathogen control and host recovery in shrimp aquaculture. - Source: PubMed
Publication date: 2026/06/30
Chen YihuanYi LiyuanZhang LeZheng YimingChen ChenWang YaohuaShang ShilinYan MaocangZhou QianjinChen Jiong