Human forkhead box O3,FOXO3 ELISA Kit
- Known as:
- Human forkhead box O3,FOXO3 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 201-12-0627
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sunredbio SunBT Sun red bio
- Gene target:
- Human forkhead box O3 FOXO3 ELISA Kit
Related genes to: Human forkhead box O3,FOXO3 ELISA Kit
- Gene:
- FOXO3 NIH gene
- Name:
- forkhead box O3
- Previous symbol:
- FKHRL1, FOXO3A
- Synonyms:
- AF6q21, FOXO2
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-23
- Date modifiied:
- 2015-08-25
Related products to: Human forkhead box O3,FOXO3 ELISA Kit
Related articles to: Human forkhead box O3,FOXO3 ELISA Kit
- Cerebral small vessel disease (CSVD) is a leading cause of post-stroke cognitive impairment, depression, and disability in older adults. Forkhead box O3 (FOXO3) is a key transcription factor that plays important roles in neurodegenerative and vascular diseases. This study investigated the correlation of acute-phase plasma FOXO3 levels with cognitive and depressive symptoms in CSVD patients. - Source: PubMed
Publication date: 2026/08/22
Sun QiqiLiu LeiMa HaoranWei ChenchenMa Aijun - Cobalt(II) chloride (CoCl) in vitro models are widely used to study hypoxia-associated endothelial dysfunction, but exposure conditions and biological endpoints remain poorly standardized, and the temporal sequence of the underlying events is largely uncharacterized. This study aimed to establish a standardized model of severe CoCl-induced endothelial dysfunction and characterize its temporal progression. - Source: PubMed
Publication date: 2026/08/22
Kolesnikov Andrey EPetrova Anastasia ACherednichenko Vadim RElizova Natalia VGladysheva Nadezhda PZakharova Elena NKirichenko Tatiana VMarkin Alexander M - The mechanical properties of the tumor microenvironment fundamentally influence cancer progression, while how viscoelastic cues interface with epitranscriptomic regulation to control cell fate remains poorly understood. Here, a pair of hyaluronic acid-based supramolecular hydrogels with tunable network dynamics are engineered to mimic the viscoelastic properties of tumor ECM. Human osteosarcoma (HOS) cells encapsulated in highly dynamic (HD) hydrogels form compact spheroids, display elevated stemness markers, and exhibit enhanced metabolic activity compared to low-dynamic (LD) matrices. Mechanistic analysis reveals that HD hydrogels strengthen E-cadherin adhesion and activate an AMPK-N-methyladenosine (mA) methylation signaling cascade, which increases the translation of FOXO3 mRNA and drives autophagy. This mechanics-driven mA-autophagy axis maintains self-renewal and promotes chemoresistance. In vivo, HD hydrogel-delivered spheroids exhibit enhanced tumor growth and chemoresistance, while autophagy inhibition markedly improves cisplatin efficacy against the grafted tumors. These findings establish viscoelasticity as a key upstream regulator of mA-dependent autophagy in osteosarcoma and identify mechanical regulation of m6A modification on specific autophagy-related transcripts as a promising target for combination therapy. - Source: PubMed
Publication date: 2026/08/16
Zhang YuemanHuang ChutianZhang YuxiaoZhang YangDeng HuiyaoGuo WeitangLi ZhuoXu XiayiZhang YuZhang KunyuBian Liming - Memory T cells exhibit long-term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1-binding protein 3 (HS1BP3) is preferentially expressed in memory CD8 T cells. HS1BP3 deficiency reduced memory-associated gene expression in CD8 OT-1 T cells following Listeria monocytogenes-ovalbumin infection and impaired antitumor responses. Loss of HS1BP3 induces metabolic reprogramming characterized by reduced oxidative phosphorylation (OXPHOS) and altered nicotinamide metabolism, accompanied by increased NAD and nicotinamide metabolite 1-methylnicotinamide (MNAM) abundance. HS1BP3 interacted with Sirtuin 1 (SIRT1), and its deficiency is associated with increased SIRT1 activity, enhanced Forkhead box O3 (FOXO3) signaling, and reduced expression of memory-associated transcription factor B cell lymphoma 6 (BCL6). Moreover, accumulation of MNAM impairs the antitumor activity of CD8 T cells. Importantly, elevated levels of HS1BP3 drive chimeric antigen receptor (CAR) -T cells towards a memory phenotype and improve tumor control. Collectively, our findings identify HS1BP3 as a regulator of CD8 T cell memory and indicate that its effects are associated with alterations in nicotinamide metabolism and the SIRT1-FOXO3-BCL6 signaling axis. These observations support the therapeutic potential of HS1BP3-engineered CAR-T cells across solid tumors. - Source: PubMed
Publication date: 2026/08/21
Wang SiyangFan XiaoqianHuang YifanYao ChangFan JixingPing YuZhao XuanLi CongcongShen ChunyiShan JiqiLiu JinyanWang ShengdianZhang ZhenZhang Yi - Maternal high-fat diet (HFD) contributes to developmental programming through placental adaptations; however, the effects of exposure timing before and during pregnancy remain unclear. - Source: PubMed
Publication date: 2026/08/18
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