Raf1 (Phospho_Ser259) Antibody
- Known as:
- Raf1 (Phospho_Ser259) Antibody
- Catalog number:
- E011006-2
- Product Quantity:
- 100ug
- Category:
- Antibodies
- Supplier:
- EnoGene
- Gene target:
- Raf1 (Phospho_Ser259) Antibody
Related genes to: Raf1 (Phospho_Ser259) Antibody
- Gene:
- RAF1 NIH gene
- Name:
- Raf-1 proto-oncogene, serine/threonine kinase
- Previous symbol:
- -
- Synonyms:
- Raf-1, c-Raf, CRAF
- Chromosome:
- 3p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: Raf1 (Phospho_Ser259) Antibody
Related articles to: Raf1 (Phospho_Ser259) Antibody
- Growth hormone (GH) stimulation tests have limited reliability and may lead to false-positive results. - Source: PubMed
Publication date: 2026/05/07
Plachy LukasDusatkova PetraKavciak LukasAmaratunga Shenali AnneSlavenko MatveiDrabova JanaMaratova KlaraNeuman VitObermannova BarboraKolouskova StanislavaSnajderova MartaSumnik ZdenekLebl JanPruhova Stepanka - This study aimed to investigate the neuroprotective effects of vitamin D (cholecalciferol, hereinafter referred to as VitD) in acute epilepsy mouse models by examining its modulation of the calcium-sensing receptor (Casr), the Ras signalling pathway, and the potential mediator role of guanine nucleotide-binding protein subunit beta-1 (Gnb1). - Source: PubMed
Publication date: 2026/05/14
Liu JiahaoLi JiaweiFu RutingFang LiyaLiu YuanyuanLiu RuiciKong DemingJiang ZhimeiLiu LeiWang LuchuanGong ChaoZeng PeiFu YoudiZhu XinruGuo JinZhou Shaobo - The classical RAS family of proteins consist of four isoforms HRAS, KRAS4a, KRAS4b, and NRAS, mutations in which lead to several types of human cancer, including pancreatic, colorectal, lung, and melanoma. RAS proteins function as molecular switches in the cell that control cell growth and proliferation. Two critical elements for RAS activation are loading of a molecule of GTP and localization to the plasma membrane. This last element is facilitated by the post-translational modification of the C-terminus, where three C-terminal residues are cleaved, and a cysteine is both farnesylated and methylated to generate a hydrophobic lipid tail that can insert into the membrane. Using an insect cell expression platform previously used to produce post-translationally modified KRAS4b, we describe a protocol here that leads to milligram quantities of protein for HRAS, KRAS4a, and NRAS targets. We also show that these proteins can bind the RAS binding domain of RAF1 and bind lipid nanodiscs. Production of these three post-translationally modified proteins is important for future novel drug-screening campaigns. - Source: PubMed
Publication date: 2026/05/15
Perkins ShelleyKrahnke SophieLarsen Erik KDrew MatthewFrank Peter HHong MinRabara DanaWall Vanessa EGrose CarissaGillette WilliamEsposito DominicStephen Andrew GMessing Simon A - Radiation-induced gliomas (RIGs) can occur in regions of the central nervous system (CNS) previously irradiated for primary malignancies including leukemia, medulloblastoma, and ependymoma. Prognosis is uniformly poor despite treatment with standard of care therapy with radiation ± alkylating chemotherapy. Recent studies have shown that a subset of patients have gene fusions in targetable receptor tyrosine kinases (RTKs) including MET, NTRK2, and RAF1. However, clinical response and outcome to targeted therapy in this patient population have not been described. - Source: PubMed
Publication date: 2026/04/28
Ford NolanDlouhy Brian JGreenlee Jeremy DBuatti John MCleppe JasonMa DeqinEschbacher Kathryn LAbath Neto Osorio LopesGroves Andrew - Yinxingye tablets have been extensively used for cardiovascular and cerebrovascular diseases; however, their specific constituents, antioxidant effects, and underlying mechanisms remain insufficiently defined. This study aimed to characterize and quantify the active constituents of Yinxingye tablets and explore their antioxidant mechanisms by network pharmacology analysis. A total of 184 constituents in Yinxingye tablets were characterized by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), and six major flavonoids were selected for quantitative analysis using high-performance liquid chromatography. Based on virtual target prediction, 211 targets of 76 active constituents with identifiable structures were identified, and HSP90AA1, SRC, CASP3, MAPK8, MMP9, IGF1, RAF1, and PPARG were defined as the hub targets involved in the antioxidant stress effects of Yinxingye tablets. Bilobalide, pinoresinol diglucoside, rutin, kaempferol-3-O-rutinoside, together with certain organic acids and ginkgolides, were suggested to function as pivotal contributors to the antioxidant stress effects of Yinxingye tablets. Network pharmacology and molecular docking analyses indicated that typhaneoside, narcissin, kaempferol-3-O-rutinoside, and rutin could be major contributors to these effects, potentially acting through hub targets MAPK8, SRC, and IGF1. - Source: PubMed
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