c_Cbl (phospho_Tyr700) Antibody
- Known as:
- c_Cbl (phospho_Tyr700) Antibody
- Catalog number:
- E011549-1
- Product Quantity:
- 50ug
- Category:
- Antibodies
- Supplier:
- EnoGene
- Gene target:
- c_Cbl (phospho_Tyr700) Antibody
Related products to: c_Cbl (phospho_Tyr700) Antibody
Related articles to: c_Cbl (phospho_Tyr700) Antibody
- The cognitive paradigm in medical education is undergoing a transition from traditional knowledge transmission to learner-centered knowledge construction. In China, this shift is aligned with the Outline of the Plan for the Construction of China into an Education Powerhouse (2024-2035), which mandates high-quality, intrinsic development in nursing curricula. While Constructivist Learning Theory (CLT)-based teaching methods (eg, PBL, CBL, and situational simulation) have been widely explored across Chinese nursing institutions, the evidentiary base remains geographically fragmented and methodologically heterogeneous. A systematic synthesis is required to inform national evidence-based educational reforms. - Source: PubMed
Publication date: 2026/07/06
Yang JunGe JiejieLi MengyuanZhang ChuanyingPeng Sijing - The integration of "Internet+" technologies into medical education has prompted the evolution of traditional teaching models. Case-based learning (CBL), a student-centered approach, is widely used in integrated curricula such as Clinical Pathophysiology & Therapeutics (CPPT). However, the comparative effectiveness of "Internet+" CBL versus traditional CBL in this context remains underexplored. - Source: PubMed
Publication date: 2026/07/03
Hu HaoyuanWang JialeWang XinqiChen YourongZhao JiahuiWang Songyun - Case-based learning (CBL) is increasingly used across health professions education to promote clinical reasoning and professional competencies. In paediatric cardiology, rapid advances in diagnostics, interventions, and multidisciplinary care have intensified the need for educational approaches that integrate complex knowledge with real-world problem-solving. - Source: PubMed
Publication date: 2026/07/06
O'Halloran KateMcMahon Colin J - Prostate cancer (PCa) is characterized by significant metabolic heterogeneity, particularly in glutathione (GSH) metabolism. Elevated GSH metabolism is closely linked to PCa progression, therapeutic resistance, and poor clinical outcomes. Recent studies have highlighted the impact of protein butyrylation on cancer biology, although related therapeutic strategies remain limited. Herein, we utilized a cysteine-based, GSH-responsive polymer (Cys8E) to deliver a broad-spectrum antitumor agent CBL0137. Exploiting high GSH levels in PCa cells, the resulting CBL0137-loaded nanoparticles (Cys8E@CBL NPs) achieved targeted and efficient intracellular delivery and enhanced tumor-killing efficacy. Mechanistic investigations revealed that upon internalization by tumor cells, Cys8E NPs perturbed butyrate-associated metabolic homeostasis, as reflected by altered abundance of related metabolic enzymes and increased intracellular protein butyrylation levels. This metabolic remodeling was accompanied by enhanced lysine-95 butyrylation of PGAM5, which promoted necroptosis. Collectively, these findings define Cys8E@CBL NPs as a redox-responsive formulation in which the carrier contributes to therapy not only by improving CBL0137 delivery but also by reshaping butyrate-associated metabolism. This process promotes PGAM5 K95 butyrylation and strengthens necroptotic tumor cell killing. These results extend the design rationale of nanomedicine from passive payload transport toward active regulation of metabolism-dependent post-translational signaling in prostate cancer. - Source: PubMed
Publication date: 2026/07/05
Luo TianlongWang LiyingCheng BishengFu JianhanZhou QianghuaZhuang YaliZhong HaitaoWu YongxinZhuang WeiWu JunHuang Hai - This prospective repeated-measures quasi-experimental educational study, conducted across two consecutive first-year medical school cohorts, aimed to develop and implement case-based learning (CBL) modules using three-dimensional (3D) models and magnetic resonance imaging (MRI) within an extended reality (XR) environment. The intervention integrated anatomical variations and anomalies to enhance immediate learning and long-term knowledge retention. - Source: PubMed
Publication date: 2026/07/04
Aytaç GüneşKalehuawehe KalāwenaPagat ShawneaOktay CemilRettenmeier ChristophLee U-YoungRomine RebeccaLozanoff Scott