Biotin, Mab anti-, HRP
- Known as:
- Biotin, Mab (anti-) to-, horseradish peroxidase
- Catalog number:
- abm032211
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Accurate
- Gene target:
- Biotin Mab anti- HRP
Related genes to: Biotin, Mab anti-, HRP
- Gene:
- GOLGB1 NIH gene
- Name:
- golgin B1
- Previous symbol:
- -
- Synonyms:
- GCP, GCP372, giantin, GOLIM1
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-05
- Date modifiied:
- 2016-10-05
- Gene:
- SERPINA1 NIH gene
- Name:
- serpin family A member 1
- Previous symbol:
- PI
- Synonyms:
- AAT, A1A, PI1, alpha-1-antitrypsin, A1AT, alpha1AT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- SERPINB1 NIH gene
- Name:
- serpin family B member 1
- Previous symbol:
- ELANH2
- Synonyms:
- EI, PI2, anti-elastase
- Chromosome:
- 6p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-27
- Date modifiied:
- 2016-04-06
Related products to: Biotin, Mab anti-, HRP
Related articles to: Biotin, Mab anti-, HRP
- Septic shock is a life-threatening syndrome characterized by immune dysregulation, oxidative injury, and high mortality. To identify candidate regulators linking immunity and ferroptosis in septic shock, we integrated expression quantitative trait loci (eQTL)-based Mendelian randomization (MR) with transcriptomic datasets from septic shock patients and controls. Differentially expressed genes overlapping with MR-prioritized genes were further evaluated using 113 machine-learning models, among which the glmBoost plus elastic net model (alpha = 0.9) showed strong discriminatory performance, with area under the curve (AUC) values of 0.999 in GSE26378, 0.980 in GSE26440, and 0.987 in the meta-cohort. The final model retained four risk genes, SERPINB1, DDAH2, SLC22A4, and CEACAM6. Among them, SLC22A4/OCTN1, an ergothioneine transporter, was associated with neutrophil-related immune features and better survival-related outcomes, whereas CEACAM6 showed a distinct pattern associated with immune dysregulation. Protein-ligand docking predicted potential interactions between candidate compounds and selected target proteins. In neutrophil-based validation experiments, SLC22A4 perturbation altered inflammatory cytokine production, STING-associated signaling readouts, and ferroptosis-related markers. Additional transporter-related assays showed that SLC22A4 knockdown reduced intracellular ergothioneine accumulation and that ergothioneine supplementation partially rescued erastin-induced viability loss and lipid ROS accumulation. In a cecal ligation and puncture (CLP) model, D-carnitine hydrochloride, STING-IN-5, and Keap1-Nrf2-IN-9 reshaped inflammatory cytokine responses and were associated with partial attenuation of septic lung injury. These findings suggest that SLC22A4 may represent a candidate regulator connecting immune remodeling with ferroptosis-associated dysfunction in septic shock; however, independent cohort validation, direct in vivo target-engagement studies, and further mechanistic analyses are required before therapeutic translation. - Source: PubMed
Publication date: 2026/06/11
Liu LifengYao YongdongYe JingjingZhuang HangLi YimingHuang YanjingLiu Chunyu - Jalili syndrome (JS) is an autosomal recessive disorder with cone-rod dystrophy and amelogenesis imperfecta caused by CNNM4 variants. This study describes salivary proteome patterns observed in a small female JS cohort to characterize the oral molecular environment. - Source: PubMed
Publication date: 2026/03/24
Rattanapornsompong KhantiSriwattanapong KanokwanGavila PatcharapornRinkrathok MawikaSriwangyang KanokratJung Han SungPorntaveetus Thantrira - Immune dysregulation is central to the pathogenesis of sepsis, yet the underlying immunomodulatory mechanisms in pediatric sepsis remain insufficiently defined. This study aimed to elucidate key immune-related gene signatures and cellular features associated with pediatric sepsis. - Source: PubMed
Publication date: 2026/02/20
Shi JiaJiang JianzeYe JinDai Wei - Perivascular macrophages play a significant role in the pathogenesis of hypoxia-induced pulmonary hypertension via crosstalk to pulmonary artery smooth muscle cells (PASMCs) to stimulate their proliferation and pulmonary vascular remodeling. However, whether hypoxia exposure of macrophages affects cellular crosstalk remains entirely unclear. This study aimed to decipher the effects of hypoxia on macrophages' crosstalk to PASMCs and elucidate the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/01/07
Hao JiajinFang GuangyaoLi XiuchuanWang TingPeng KeLiu JinchengYang DachunKang XiaWang QiangYang YongjianLan Cong - Porcine deltacoronavirus (PDCoV) is an emerging porcine enteric coronavirus in China, with the risk of cross-species transmission and zoonotic infection. SERPINB1, serine protease inhibitor, is a potential therapeutic target. It is unclear whether its role in PDCoV replication. Our study found that PDCoV infection upregulates the expression level of SERPINB1, suggesting a potential role for SERPINB1 in the viral life cycle. Further investigation revealed that SERPINB1 is an essential factor for viral replication, and its RCL domain is the key region for its viral-promoting activity. Moreover, SERPINB1 interacts with accessory protein NS7a of PDCoV. Understanding the mechanism by which SERPINB1 targets viral encoded proteins to promote PDCoV replication can enrich the pathogenesis and immune mechanism of PDCoV, and provide new targets and important theoretical basis for the development of antiviral drugs. - Source: PubMed
Publication date: 2025/12/30
Yan JunfangLiu XinruZhu HuixinLi LiangPan HongyeBao RenjieLi QiutianSun JingSong HouhuiSu Mingjun