Human Polyclonal LRP5 Ab
- Known as:
- Human Polyclonal LRP5 Antibody
- Catalog number:
- a0130
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- ABclonal
- Gene target:
- Human Polyclonal LRP5
Related genes to: Human Polyclonal LRP5 Ab
- Gene:
- LRP5 NIH gene
- Name:
- LDL receptor related protein 5
- Previous symbol:
- LRP7, OPPG, EVR1
- Synonyms:
- LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-07
- Date modifiied:
- 2016-10-05
Related products to: Human Polyclonal LRP5 Ab
Related articles to: Human Polyclonal LRP5 Ab
- Dickkopf (DKK) family proteins (DKK1-DKK4), which function as extracellular modulators of Wnt signaling, contain two cysteine-rich domains: CRD1 and CRD2. In DKK1, CRD1 modulates interaction with its receptor low-density lipoprotein receptor-related protein (LRP) 5/6, whereas CRD2 directly binds to LRP5/6. The crystal structure of human DKK4-CRD1 was determined at 1.83 Å resolution. Crystals were obtained from refolded protein expressed as inclusion bodies and belonged to space group P2, with two molecules in the asymmetric unit. Initial molecular-replacement attempts using the solution NMR structure were unsuccessful, whereas an AlphaFold2-predicted model provided a clear solution. The refined structure reveals a compact fold comprising N- and C-subdomains connected by a linker region and stabilized by five conserved disulfide bonds. The crystal structure closely resembles the AlphaFold2 model, but shows larger deviations from the NMR ensemble. ANSURR analysis and hydrogen-bond comparisons indicate that the NMR models underestimate structural rigidity, particularly in β-sheet regions, owing to fewer stabilizing hydrogen bonds. Notably, enhanced conformational variability is observed in the N-subdomain, suggesting a potential role for structural plasticity in ligand recognition. - Source: PubMed
Publication date: 2026/07/01
Shibata Naoki - Exome sequencing (ES) has improved Mendelian disease diagnosis, but in consanguineous populations, biallelic variants in typically dominant genes remain underrecognized. This study characterized their clinical and molecular features and explored pathway-level patterns of dual inheritance. Exome data from 1450 individuals analyzed between 2022 and 2024 were retrospectively reviewed. Biallelic variants were filtered in genes annotated as autosomal dominant in OMIM. A pathway-based analysis using Gene Ontology and STRING identified functionally related genes, and those showing both dominant and recessive inheritance were further evaluated with gnomAD constraint metrics to explore shared mechanisms. Five consanguineous families carried biallelic variants in genes typically associated with dominant inheritance, accounting for ~3.1% of all homozygous pathogenic variants. Mechanisms included hypomorphic effects (TERC, ASH1L), semidominant dosage sensitivity (LRP5), structural or positional effects (FBN1), and complete loss of function with pleiotropy (SMAD6). Pathway analysis revealed dosage-sensitive dynamics in telomere maintenance, extracellular matrix, Wnt/BMP signaling, and histone modification, supporting dual-inheritance behavior driven by gene dosage and functional impact. Our findings show that genes labeled autosomal dominant can also cause disease biallelically, reflecting a dosage-sensitive continuum. Including such analyses in diagnostic pipelines, especially in consanguineous populations, can refine understanding of inheritance in rare disorders. - Source: PubMed
Publication date: 2026/06/18
Taşdelen ElifcanTekbaş Umut CanKolkıran AbdulkerimÇetinkaya SemraKılıç MustafaSezer Abdullah - Two hundred Holstein dairy cows (milk yield of 34.5 ± 0.6 kg/d, 3.1 ± 1.2 lactations) were enrolled to investigate the role of WNTs signaling network in early pregnancy loss. The ISG15 mRNA abundance of uterine luminal cells obtained via brushing on day 16 after service was used to determine initial pregnancy status, with confirmation via ultrasound on days 32 and 60. The mRNA abundance of cells obtained from uterine brushing for WNT2, WNT5A, WNT7A, WNT11, frizzled receptors (FZD), dickkopf proteins (DKK1), Kremen and LDL receptor related protein (LRP 5/6), lymphoid enhancer-binding factor 1 (LEF1) and transcription factor 7 (TCF) was determined at day16 after insemination. Relative mRNA abundance of DKK1 (1.98-fold), WNT5A (2.67-fold), WNT7A (1.83-fold) and WNT11 (2.16-fold) genes in pregnant cows were significantly greater than in cows with early embryonic mortality (P < 0.05). In contrast, relative mRNA abundance of WNT2 (3.35-fold) and FZD6 (5.50-fold) genes were significantly greater in pregnant-embryo loss cows compared to pregnant cows on day 16 (P < 0.05). The relative mRNA abundance of LRP5, LRP6, LEF1, FZD3, FZD5, FZD8 and TCF genes were not affected by pregnancy status although their variances were lower; however, there was a negative correlation among ISG15 and these genes. In conclusion, differences in mRNA abundance of WNT signaling genes in uterine brushing samples are associated with pregnancy status in lactating dairy cows and may contribute to minimizing early bovine pregnancy losses. - Source: PubMed
Publication date: 2026/06/04
Dirandeh EAnsari-Pirsaraei ZThatcher W W - Recognition of Wnt proteins by Frizzled (Fzd) receptors and the low-density lipoprotein receptor-related protein 5/6 (LRP5/6) co-receptor is essential for canonical Wnt signaling. It remains enigmatic how Wnt simultaneously interacts with Fzd and LRP5/6 and activates intracellular Wnt/β-catenin signaling. Here, we report cryo-electron microscopy (cryo-EM) structures of Wnt3a/Fzd8/LRP6 extracellular complexes captured in a 2:4:2 stoichiometry, consisting of a Wnt3a-Wnt3a homodimer, whereby each Wnt3a monomer binds to two Fzd8 receptors and one LRP6 co-receptor. This implies that Wnt3a induces Fzd cystine-rich domain (Fzd-CRD) tetramerization, which in turn could promote recruitment of oligomeric Disheveled (Dvl) to Fzd on the cytoplasmic side. Indeed, mutations of key Wnt3a-Wnt3a interface residues abolish Fzd-LRP clustering and downstream signaling, supporting a critical role of Wnt3a-Wnt3a dimerization in Wnt signalosome assembly and signaling. Our structures also show how the Wnt3a N-helical domain recognizes the LRP6 extracellular domain (LRP6-ECD) E3 β-propeller, while the Wnt3a N-C hairpin interacts with the valley between LRP6-E3 and -E4 propellers, underpinning the development of targeted Wnt therapeutics. - Source: PubMed
Publication date: 2026/05/27
Yue DanSun GangyuCao YunlongLi HongyueYang YufengPan ZirunXue LuluZhang LuWang ZhizhiXu Wenqing - Cancer stem cells (CSCs) drive colorectal cancer (CRC) therapeutic resistance through metabolic reprogramming, particularly aerobic glycolysis. Strategies simultaneously targeting CSC metabolism and stemness remain limited. - Source: PubMed
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