Mouse apelin 12(AP12) ELISA Kit
- Known as:
- Mouse apelin 12(AP12) Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 21621
- Product Quantity:
- 96T
- Category:
- Peptides
- Supplier:
- Bio-Medical
- Gene target:
- Mouse apelin 12(AP12) ELISA Kit
Related genes to: Mouse apelin 12(AP12) ELISA Kit
- Gene:
- APLN NIH gene
- Name:
- apelin
- Previous symbol:
- -
- Synonyms:
- apelin, XNPEP2
- Chromosome:
- Xq26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-01
- Date modifiied:
- 2016-10-05
Related products to: Mouse apelin 12(AP12) ELISA Kit
Related articles to: Mouse apelin 12(AP12) ELISA Kit
- : Aging is a major risk factor that exacerbates acute kidney injury (AKI) and subsequent renal fibrosis. However, age-related factors contributing to post-AKI fibrotic remodeling remain underexplored. This study aimed to investigate the protective potential of apelin, an endogenous peptide, in mitigating post-AKI renal fibrosis in aged mice. : A mouse model of AKI was established in 8-week-old and 19-month-old male C57BL/6 mice by clamping the left renal artery for 40 min, followed by reperfusion and euthanasia 2 weeks post-ischemia. To evaluate the protective effect of apelin pretreatment, the 19m-APLN group received intraperitoneal apelin administration (25 μg/kg/day) for 2 weeks prior to AKI induction. The effects of apelin on renal fibrosis were evaluated using renal function tests (blood urea nitrogen, serum creatinine levels), histological analysis, and Western blotting. : The 19m-AKI group exhibited more severe renal damage and interstitial fibrosis, along with a marked reduction in apelin and APLNR expression compared to the 8wk-AKI group. Apelin-13 pretreatment attenuated renal injury and fibrotic remodeling in aged mice, with reduced collagen deposition accompanied by lower pro-TGF-β1 expression and SMAD3 phosphorylation. : These results highlight the protective role of apelin against age-related exacerbation of post-AKI renal fibrosis, suggesting that prophylactic Apelin-13 administration may attenuate post-I/R renal injury and fibrotic remodeling in aged kidneys. - Source: PubMed
Publication date: 2026/09/10
Oh Won-SeokLee Sang GonKim Hyun TaeMoon Ji-HyunChoi Ah-LaHan Seung YunKim Do KyungLee Nam SeobJeong Young GilHong Geum-Lan - In this study, we aimed to investigate the immunohistochemical expression of apelin in tissue samples obtained from patients with Cushing's syndrome (CS) due to cortisol-producing adrenal adenoma (CPA) and to compare these findings with normal adrenal cortex tissue. Additionally, we sought to evaluate the association of apelin expression with clinical, hormonal, and histopathological parameters. The expression profile of vascular endothelial growth factor (VEGF) was also assessed to explore potential angiogenic interactions. - Source: PubMed
Publication date: 2026/09/16
Çalişkan Burgucu HaticeGünler TuğbaÖmeroğlu EthemÜnlü YaşarAksu Oğuzhan - Neurofibromatosis type 2 (NF2)-associated meningiomas and schwannomas are vascular tumors, and while vascular endothelial growth factor (VEGF) inhibition with bevacizumab has benefited some NF2-related schwannomas, most NF2-associated meningiomas remain nonresponsive. - Source: PubMed
Publication date: 2026/08/17
Bhattacharyya SrirupaBeauchamp Roberta LRamesh Vijaya - Degenerative diseases of the musculoskeletal system, including sarcopenia, osteoarthritis, and osteoporosis, represent a cluster of age-associated conditions pathologically linked to chronic inflammation, oxidative stress imbalance, and endocrine dysregulation. These musculoskeletal diseases have emerged as a critical public health concern in aging populations worldwide, significantly compromising functional mobility and overall quality of life. Apelin, an endogenous ligand for the G protein-coupled receptor apelin receptor (APJ), constitutes a crucial component of the apelin/APJ signaling system that exhibits extensive distribution throughout human physiological systems. The multifaceted regulatory roles of apelin in cellular homeostasis, tissue remodeling, and inflammatory responses position it as a promising therapeutic target for these degenerative conditions. This review mainly discusses the effects of apelin on the occurrence and development of degenerative diseases in different musculoskeletal systems, aiming to establish a scientific foundation for future investigations and to identify novel therapeutic strategies for these conditions. - Source: PubMed
Publication date: 2025/08/02
Xu JinkunLi HengzhenSun JianfengLiu GaomingYao YumingYuan DongliangXiao WenfengLi Yusheng - - Source: PubMed
Publication date: 2026/07/22
Guo JiwuWu WenzhangQi YujingGuo LingyunMao JieLi Yumin