Shigella Dysenteriae Card
- Known as:
- Shigella Dysenteriae Card
- Catalog number:
- ODZ-273
- Product Quantity:
- Tests in kit 20
- Category:
- -
- Supplier:
- Vidia
- Gene target:
- Shigella Dysenteriae Card
Related genes to: Shigella Dysenteriae Card
- Gene:
- MAVS NIH gene
- Name:
- mitochondrial antiviral signaling protein
- Previous symbol:
- -
- Synonyms:
- VISA, KIAA1271, IPS-1, Cardif
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2009-04-01
- Date modifiied:
- 2017-09-22
Related products to: Shigella Dysenteriae Card
Related articles to: Shigella Dysenteriae Card
- Vaccination (immune priming) against Ostreid herpesvirus 1 (OsHV-1) is a strategy for managing Pacific Oyster Mortality Syndrome (POMS), yet the transcriptional mechanisms underlying protection remain poorly defined. We evaluated the transcriptome in Pacific oysters (Magallana gigas) administered heat-treated (HT) and live OsHV-1 vaccines at 18 °C and 22 °C. All priming strategies improved survival after challenge with virulent OsHV-1 at 22 °C, with relative percent survival of 57.5% for HT OsHV-1 administered at 18 °C, 76.2% for HT OsHV-1 at 22 °C and 85.0% for live OsHV-1 at 18 °C. Primed surviving oysters exhibited significantly lower viral loads after challenge than controls, with distinct transcriptomic responses among live and HT OsHV-1 treatments. Live OsHV-1, which provided the highest protection, triggered a rapid antiviral response one day after priming, characterised by upregulation of predicted orthologs of viral RNA sensors and interferon-stimulated-like signalling components including RLR-family genes, DHX58, IFI44L and a MAVS-like adaptor. In contrast, HT OsHV-1 induced a delayed response on day four, enriched for protein quality control, endoplasmic reticulum-associated degradation and ribosome biogenesis pathways. By day 12, gene expression of primed oysters had returned to baseline. In live OsHV-1-primed oysters, post-challenge gene modules were enriched for predicted orthologs of antiviral and immune signalling components and DNA replication regulators, indicative of a coordinated antiviral response and increased haemocyte activity. Overall, these results highlight transcriptional signatures underlying OsHV-1-based vaccination, which is developing as a strategy in integrated POMS management. - Source: PubMed
Publication date: 2026/09/10
Hossain ArmanWhittington RichardCosta Vincenzo ACampbell LeePathirana ErandiSamsing Francisca - Berberine is an isoquinoline alkaloid derived from various medicinal plants, including Coptis chinensis. Berberine exhibits multiple biological activities, including immune modulation, antibacterial activity, and antioxidant properties. Wenchang chicken is a local breed from Hainan Province, China, which is still primarily raised under free-range conditions. In this study, we compared the effects of dietary berberine supplementation on body measurements, weight, meat quality, serum immunoglobulin levels, antioxidant indices, liver transcriptome, proteome, and phosphoproteome in Wenchang chickens. Berberine had no significant effect on the body measurements and weights of Wenchang chickens. However, it significantly altered the color of the breast muscles and significantly reduced the shear force of the breast and leg muscles. Berberine also significantly increased serum Immunoglobulin A(IgA) and Immunoglobulin M(IgM) concentrations and glutathione (GSH) activity in Wenchang chickens, while significantly decreasing malondialdehyde (MDA) concentration. RNA-seq identified 764 differentially expressed genes (DEGs) in the liver. The significantly enriched GO terms were related to immune and inflammatory processes, such as cell chemotaxis, granulocyte migration, and chemotaxis. GSEA identified 50 gene sets, many of which were associated with immune regulation and inflammatory responses, such as Hedgehog signaling, interferon alpha response, and IL-6 JAK-STAT3 signaling. Liver proteomics identified 530 differentially abundant proteins (DAPs), some of which were associated with innate immune responses, such as mitochondrial antiviral signaling protein (MAVS), TNF receptor-associated factor 3 (TRAF3), and BH3-interacting domain death agonist (BID) in the Herpes simplex virus 1 infection pathway. Joint analysis of transcriptome and proteome revealed a highly significant positive correlation between mRNA expression and protein abundance in the liver. A total of 3,482 phosphorylated proteins containing 39,142 phosphorylation sites were identified in Wenchang chicken livers. Among these, 2,086 phosphorylation sites in 714 phosphorylated proteins were significantly upregulated, whereas 2,426 phosphorylation sites in 659 phosphorylated proteins were significantly downregulated in the livers of berberine-treated Wenchang chickens. These phosphoproteins were significantly enriched in KEGG pathways associated with defense, immune signaling regulation, and apoptosis, such as the mTOR signaling pathway, Salmonella infection, and autophagy. This study provided foundational data for the application of berberine in broiler production. - Source: PubMed
Publication date: 2026/06/25
Zhang XiaohuiQi YanxiaXu TieshanGu LihongWu LehuanPeng YihuiWang ShuyangLiang WuZheng Xinli - Mitochondria function not only as metabolic and bioenergetic centers but also as critical signaling hubs that integrate cellular context with innate immune response. The mitochondrial antiviral-signaling protein (MAVS), anchored to the outer mitochondrial membrane, is a central adaptor in the RIG-I-like receptor (RLR) pathway, orchestrating type I interferon (IFN) production and apoptosis. Although long regarded as a docking platform for RLR-derived signals, recent advances, particularly concerning its diverse post-translational modifications (PTMs), reveal MAVS as a dynamic integrator that decodes cellular stress and metabolic cues to fine-tune antiviral immunity. Canonical PTMs such as ubiquitination and phosphorylation highlight the importance of precisely controlling both the initiation and downregulation of MAVS signaling, but recent discoveries substantially broaden this regulatory landscape. Stress-responsive phosphorylation mediated via the ASK1-p38 MAPK pathway enhances MAVS signaling capacity under oxidative and ER stress, linking cellular damage to amplified interferon production. In parallel, a newly identified vitamin K-dependent carboxylation of MAVS reshapes downstream signaling by promoting interferon induction while restraining apoptosis, introducing a regulatory layer that may reflect the metabolic context surrounding GGCX activity, including vitamin K availability. Understanding this multilayered regulatory network not only redefines MAVS as a stress-sensitive mitochondrial signaling hub responsive to cellular context but also highlights new avenues for therapeutic modulation of innate immunity and cell fate during viral infection. This review summarizes emerging insights into PTM-mediated regulation of MAVS and outlines their broader implications for mitochondrial antiviral signaling. - Source: PubMed
Publication date: 2026/08/27
Morimoto NaoOkazaki Tomohiko - The mitochondrial antiviral signaling protein (MAVS) is a key component of the innate immune response against RNA viruses. Its involvement in other cellular stresses is largely unknown. Here, we found that hypoxia induces MAVS aggregation, leading to the stabilization of HIF1/2α proteins and the enhancement of hypoxia signaling. Mechanistic studies revealed that MAVS enhances TRAF6 binding to ECSIT, which catalyzes ECSIT polyubiquitination. This promotes mitochondrial ROS generation and likely inhibits PHD2 enzymatic activity, thereby reducing HIF1/2α proteasomal degradation. Disrupting MAVS in both mice and zebrafish decreased the expression of hypoxia response genes and reduced the tolerance of zebrafish to hypoxia. This study reveals an unexpected role of MAVS in hypoxia signaling. - Source: PubMed
Publication date: 2026/09/09
Sun XueyiZhu ChunchunLiu WenWang ZixuanDeng HongyanJia ShukeShi ShuaiXiang YuhanLuo YimanGui Jian-FangLiu XingXiao Wuhan - Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a bat-origin porcine enteric alphacoronavirus first identified in Guangdong, China in 2017, which causes severe watery diarrhea and high mortality in neonatal piglets, leading to in substantial economic losses to the global swine industry. Here, we report that SADS-CoV nsp10 functions as an IFN-λ1 antagonist. Specifically, nsp10 suppressed IFN-λ1 production independently of its zinc finger domains. Furthermore, nsp10 inhibits MAVS- and IRF1-driven IFN-λ1 expression within the RLR signaling pathway. Nsp10 blocks poly (I:C)-induced nuclear translocation of IRF1, although no direct physical interaction is detected between the two proteins. Pull-down assays combined with mass spectrometry identified hnRNPU as a nsp10-interacting protein and their direct interaction was verified by co-immunoprecipitation (Co-IP). hnRNPU alone inhibits IFN-λ1 production and synergizes with nsp10 to enhance this suppression, consequently facilitating SADS-CoV replication. Collectively, our findings uncover a previously unrecognized immune evasion mechanism employed by SADS-CoV and provide a potential therapeutic target for controlling coronavirus infections. - Source: PubMed
Publication date: 2026/09/06
Wei XiaonaZhao YukunLiu JiaxinLi JingminZhong ChunhuiZhao KeyuCao YongchangXue Chunyi