LOW ROD FOR PARA MPUX-50
- Known as:
- LOW ROD PARA MPUX-50
- Catalog number:
- MROIX-50
- Category:
- -
- Supplier:
- SBS
- Gene target:
- LOW ROD FOR PARA MPUX-50
Related genes to: LOW ROD FOR PARA MPUX-50
- Gene:
- TCF15 NIH gene
- Name:
- transcription factor 15
- Previous symbol:
- -
- Synonyms:
- EC2, PARAXIS, bHLHa40
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 1995-02-21
- Date modifiied:
- 2017-02-27
Related products to: LOW ROD FOR PARA MPUX-50
.2ml 8-Well PCR Strip Tubes, U Low Profile, Clear Flat Caps.2ml 8-Well PCR Strip Tubes, U Low Profile, Clear Flat Caps.2ml 8-Well PCR Strip Tubes, W Low Profile, Clear Caps.2ml 8-Well PCR Strip Tubes, W Low Profile, Clear Caps0.15ml 96 Well PCR Plate,No Skirt, Low Profile,Clear0.15ml 96 Well PCR Plate,No Skirt, Low Profile,White0.15ml 96 Well PCR Plate,Semi Skirt, Low Profile,Clear0.15ml 96 Well PCR Plate,Semi Skirt, Low Profile,White0.15ml PCR 8-strip Tubes,Low Profile,Clear0.15ml PCR 8-strip Tubes,Low Profile,White0.1ml 8-Strip PCR Tubes & Caps Ultra Thin Wall, Low Profile0.1ml 8-Strip PCR Tubes & Caps Ultra Thin Wall, Low Profile0.1ml 8-Strip PCR Tubes & Caps Ultra Thin Wall, Low Profile0.1ml 8-Strip PCR Tubes & Caps White, Thin Wall, Low Profile0.1ml 8-Well PCR Strip Tubes Low Profile, Clear Flat Caps Related articles to: LOW ROD FOR PARA MPUX-50
- Common forms of migraine are complex disorders characterized by significant clinical diversity. Their genetic basis has been extensively studied but remains unclear. This study represents the first pilot genome-wide association study (GWAS) integrating a polygenic risk score (PRS) in the Portuguese population, designed to identify migraine susceptibility loci through a case-control study and unravel population-specific variants. Genotyping data was acquired with Applied Biosystems Axiom™ PMDA array, producing 12,035,248 single-nucleotide polymorphisms (SNPs) post-imputation, providing a comprehensive scope for GWAS analysis. PRS models were created and tested using a k-folds cross-validation framework and the optimal significance threshold was assessed. We detected 12 potential risk loci corresponding to 12 lead SNPs (, /, , , , , , , , , and ). The top three variants (, / and ) were also supported by the PRS model. We highlight that several variants present putative biological relevance to migraine pathophysiology, reinforcing the importance of neurotransmitter release, synaptic transmission and the involvement of vascular components in migraine pathophysiology. - Source: PubMed
Publication date: 2026/06/06
De Marco RodrigoPucci KevinSantos MarianaGil-Gouveia RaquelCavadas BrunoSousa AldaAlves-Ferreira MiguelAzevedo LuísaLemos CarolinaDias Andreia - Endothelial cells (ECs) are central regulators of vascular and metabolic homeostasis, yet their organ- and depot-specific diversity remains underexplored. Two major types of adipose tissue (AT) can be distinguished that differ substantially in their physiological function and vascularization: white AT (WAT), which is the major energy storage and brown AT (BAT), which is highly vascularized and dissipates energy [1-5]. While ECs from these depots likely contribute to adipose function, their characterization has been hindered by technical limitations in isolation and culture. Here, we establish a protocol for isolating and expanding ECs from murine BAT and WAT, enabling transcriptomic and functional analyses across depots. We demonstrate that freshly isolated BAT-ECs express depot-enriched gene signatures, including Rgcc, Cdkn1c, Tcf15, Meox2, and Efnb1, several of which are dynamically regulated during cold-induced BAT activation. These findings reveal novel BAT-EC markers and highlight specialized endothelial programs that may support BAT function. However, we also uncover that culturing BAT-ECs profoundly remodels EC identity. Transcriptomic profiling shows that BAT-ECs rapidly downregulate BAT-enriched endothelial markers and acquire features resembling WAT-ECs. This dedifferentiation is accompanied by signatures of proliferation, adhesion remodeling, and endothelial-to-mesenchymal transition. While these changes present challenges for maintaining depot-specific identity in culture, they also provide a framework to better interpret experimental outcomes and to investigate EC plasticity. Taken together, our study delivers a novel isolation and culture protocol for adipose ECs, defines BAT-EC markers, and demonstrates how culture conditions reshape their identity. These insights build the foundation for future research of AT vasculature. - Source: PubMed
Publication date: 2026/03/12
Elschner TabeaGrein StephanSander JanaHildebrand StaffanHeubach LaraPannwitz NinaMircea MariaRaimundez ElbaKaragiannakou VasilikiGeorgiadi AnastasiaHeeren JoergHasenauer JanPfeifer AlexanderWilhelm-Jüngling Kerstin - One of the main challenges in Type 1 diabetes mellitus (T1DM) research is the sample size of the participants and the invasive process of collecting an adequate number of blood samples from young patients with T1DM. Therefore, it is of great interest to investigate the possibility of using saliva as a non-invasive tool to investigate the genetic factors that are associated with T1DM comorbidities. The present study aims to identify differentially expressed genes (DEGs) in saliva samples of T1DM patients with various comorbidities using transcriptomic profiling. - Source: PubMed
Publication date: 2025/10/10
Mussa Bashair MSrivastava AnkitaRajan ReejaVenkatachalam ThenmozhiAl-Habshi AbeerAbdelgadir ElaminBashier AlaaeldinAl Awadi FatheyaHafidh KhadijaHamoudi RifatAbusnana Salah - Although t (8;21) is in fact considered a good risk acute myeloid leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have shown that RNA demethylase ALKBH5 promotes leukemogenesis. However, the molecular mechanism and clinical significance of ALKBH5 in t (8;21) AML have not been elucidated. - Source: PubMed
Publication date: 2023/03/10
Li RanWu XiaoluXue KaiFeng DandanLi JianyongLi Junmin - The vertebrate peripheral nervous system (PNS) is an intricate network that conveys sensory and motor information throughout the body. During development, extracellular cues direct the migration of axons and glia through peripheral tissues. Currently, the suite of molecules that govern PNS axon-glial patterning is incompletely understood. To elucidate factors that are critical for peripheral nerve development, we characterized the novel zebrafish mutant, stl159, that exhibits abnormalities in PNS patterning. In these mutants, motor and sensory nerves that develop adjacent to axial muscle fail to extend normally, and neuromasts in the posterior lateral line system, as well as neural crest-derived melanocytes, are incorrectly positioned. The stl159 genetic lesion lies in the basic helix-loop-helix (bHLH) transcription factor tcf15, which has been previously implicated in proper development of axial muscles. We find that targeted loss of tcf15 via CRISPR-Cas9 genome editing results in the PNS patterning abnormalities observed in stl159 mutants. Because tcf15 is expressed in developing muscle prior to nerve extension, rather than in neurons or glia, we predict that tcf15 non-cell-autonomously promotes peripheral nerve patterning in zebrafish through regulation of extracellular patterning cues. Our work underscores the importance of muscle-derived factors in PNS development. - Source: PubMed
Publication date: 2022/07/09
Limbach Lauren EPenick Rocky LCasseday Rudy SHyland Maddelyn APontillo Erika AAyele Afomia NPitts Kristen MAckerman Sarah DHarty Breanne LHerbert Amy LMonk Kelly RPetersen Sarah C