APRIL (Extracellular Domain 2) Peptide
- Known as:
- APRIL (Extracellular Domain 2) Peptide
- Catalog number:
- 2415P
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- APRIL (Extracellular Domain 2) Peptide
Related genes to: APRIL (Extracellular Domain 2) Peptide
- Gene:
- ANP32B NIH gene
- Name:
- acidic nuclear phosphoprotein 32 family member B
- Previous symbol:
- -
- Synonyms:
- SSP29, PHAPI2, APRIL
- Chromosome:
- 9q22.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-13
- Date modifiied:
- 2016-10-05
- Gene:
- TNFSF13 NIH gene
- Name:
- TNF superfamily member 13
- Previous symbol:
- -
- Synonyms:
- APRIL, CD256
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2017-03-02
Related products to: APRIL (Extracellular Domain 2) Peptide
Related articles to: APRIL (Extracellular Domain 2) Peptide
- A tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe that 9- to 12-month-old APRIL transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B cell population. Aging APRIL transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer's patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into nonlymphoid tissues such as kidney and liver. We detected significantly increased APRIL levels in sera of B cell chronic lymphoid leukemia (B-CLL) patients, indicating that APRIL promotes onset of B-1-associated neoplasms and that APRIL antagonism may provide a therapeutic strategy to treat B-CLL patients. - Source: PubMed
Planelles LourdesCarvalho-Pinto Carla EHardenberg GijsSmaniotto SaletteSavino WilsonGómez-Caro RuthAlvarez-Mon Melchorde Jong JoanEldering EricMartínez-A CarlosMedema Jan PaulHahne Michael