IRAK-M Peptide
- Known as:
- IRAK-M Peptide
- Catalog number:
- 2355P
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- IRAK- Peptide
Related genes to: IRAK-M Peptide
- Gene:
- IRAK1 NIH gene
- Name:
- interleukin 1 receptor associated kinase 1
- Previous symbol:
- -
- Synonyms:
- IRAK, pelle
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-22
- Date modifiied:
- 2017-07-12
- Gene:
- IRAK3 NIH gene
- Name:
- interleukin 1 receptor associated kinase 3
- Previous symbol:
- -
- Synonyms:
- IRAK-M
- Chromosome:
- 12q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-17
- Date modifiied:
- 2016-10-11
Related products to: IRAK-M Peptide
Related articles to: IRAK-M Peptide
- ObjectiveThis study aimed to identify immune-related hub genes shared between acute myocardial infarction (AMI) and metabolic syndrome (MetS), and to construct and validate a blood-based gene diagnostic signature for AMI, with the hypothesis that this signature may be informative for AMI risk assessment in MetS patients.MethodsTwo AMI datasets (GSE66360, GSE61145) and one MetS dataset (GSE98895) were obtained from the Gene Expression Omnibus (GEO) database. Based on the GSE66360 dataset, 285 AMI-related common genes were identified as the intersection between 1409 differentially expressed genes (DEGs) and 304 module genes, identified via Limma and weighted gene co-expression network analysis (WGCNA), respectively. Subsequently, the intersection of these 285 AMI-related common genes and 1446 MetS-related DEGs yielded 40 genes that were primarily associated with immunoregulation, as revealed by functional enrichment analysis. After constructing a protein-protein interaction (PPI) network, 30 node genes were selected and ranked according to node degree. Six candidate hub genes (THBD, MMP9, IRAK3, CXCL16, NLRP3, and JDP2) identified via machine learning were used to establish a diagnostic model and evaluate its diagnostic value.ResultsWe revealed that the six candidate genes demonstrated strong diagnostic value for AMI (AUC ranging from 0.86 to 0.94, with 95% confidence intervals [CIs]). Moreover, a diagnostic nomogram constructed from these genes allows for visual quantification of AMI probability. Immune cell infiltration analysis revealed dysregulation across multiple immune cell subsets in AMI. These six immune-based hub genes have been identified as potential diagnostic biomarkers for AMI, with hypothesized relevance in MetS patients.ConclusionsThese findings provide a hypothesis-generating resource for understanding inflammatory links between MetS and AMI, though clinical utility for risk stratification in MetS patients requires further prospective validation. - Source: PubMed
Publication date: 2026/04/28
Feng NiFeng MeiguoRuan JianZhou CaiSong XiaoyingChen LiHou Shuai - Osteoarthritis (OA) is a common degenerative joint disorder associated with aging, marked by chondrocyte senescence, cartilage degradation, and chronic inflammation. Although cellular senescence significantly contributes to OA progression, the molecular mechanisms governing this process are not fully understood. Interleukin-1 receptor-associated kinase 3 (IRAK3) acts as a negative regulator of Toll-like receptor (TLR) signaling; however, its role in OA and chondrocyte senescence remains unclear. We employed bioinformatics analysis, human OA cartilage samples, a destabilization of the medial meniscus (DMM) mouse model, and assays in ATDC5 chondrocytes to explore the expression and functional role of IRAK3 in OA. To evaluate senescence, mitochondrial function, reactive oxygen species (ROS), and inflammatory signaling, we conducted gain- and loss-of-function experiments alongside biochemical and histological analyses. IRAK3 expression was markedly reduced in both human and murine osteoarthritis (OA) cartilage. Silencing IRAK3 intensified hydrogen peroxide-induced senescence, mitochondrial dysfunction, reactive oxygen species (ROS) production, and catabolic metabolism, whereas its overexpression offered protective effects. Mechanistically, IRAK3 inhibited the TLR7/TLR9–NF-κB pathway, leading to decreased secretion of pro-inflammatory cytokines and reduced chondrocyte senescence., intra-articular injection of adeno-associated virus (AAV) to knock down IRAK3 can promote the progression of OA in DMM mice. IRAK3 serves as a crucial inhibitor of chondrocyte senescence and the progression of osteoarthritis (OA) by reducing TLR-mediated inflammation and oxidative stress. These findings highlight IRAK3 as a promising therapeutic target for addressing senescence-related osteoarthritis. - Source: PubMed
Publication date: 2026/04/24
Tao TaoYin GuangrongWang LiangliangWang Yuji - Dimethyl fumarate (DMF), a cysteine targeting agent, is clinically used to treat multiple sclerosis and psoriasis. However, its precise molecular mechanism remains incompletely understood. Here, we investigated the effects of DMF on NLRP3 inflammasome activation. DMF suppresses NLRP3 inflammasome activity at both the priming and activation steps. Using chemoproteomics, we identified DMF targets in macrophages, including IRAK3/4 and RELA/B involved in the NLRP3 priming step, NEK7 involved in NLRP3 early activation, and GSDMD involved in NLRP3 late activation. To understand how DMF inhibits NLRP3 early activation, we showed that DMF modifies NEK7 Cys298 to disrupt NLRP3-NEK7 interaction and inflammasome activation. Interestingly, NEK7 Cys298 is critical for NLRP3 inflammasome activation. This study provides mechanistic insights into DMF's immunomodulatory effects and suggests that targeting NEK7 Cys298 can be a novel strategy for inflammatory diseases. Our work highlights the utility of DMF to identify functionally important cysteine residues in immune signaling pathways. - Source: PubMed
Publication date: 2026/04/21
Zhang YandongLindner HelenaSo BrianChen ZirongLi HaoyangXu JiashuWang JiaheXu JiePetre Alexandru MDistefano Mark DNúñez GabrielLin Hening - Some patients with osteoporosis (OP) do not respond to treatment with bisphosphonates; pathways that stimulate osteoclatogenesis may be involved in this failure, such as the myddosome pathway. A total of 40 OP patients and 20 controls were included in the group study. Patients treated with sodium alendronate (SA) for two years were classified according to bone mineral density (BMD) variations of the lumbar spine, femoral neck, and total hip, measured by the method of dual-energy x-ray absorptiometry (DXA) as responsive patients (OP-R) (n = 20) and non-responders (OP-NR) (n = 20), to evaluate the impact of the myddosome pathway gene expression profile in postmenopausal women with OP. The gene expressions were measured through real-time relative quantitative PCR with Taqman® probes; relative quantification was normalized to GAPDH and RPLP0 reference genes. Non-responders showed increased expression levels of MYD88 and IRAK3 compared to responders Fold change (FC) = 2.86±1.54, p=0.0002 e FC= 3.62±0.46, p<0.0001 respectively. Our results demonstrate the influence of the myddosome on OP maintenance and response to sodium alendronate (SA) treatment, highlighting the importance of this pathway as a potential target for new therapeutic approaches in postmenopausal OP. - Source: PubMed
Publication date: 2026/04/17
Oliveira Bianca Maria Ribeiro deMelo Maria Julia Alves deGuaraná Werbson LimaLima Camilla Albertina Dantas deBarbosa Alexandre DominguesSandrin-Garcia Paula - Domestic cattle (Bos taurus and Bos indicus) underpin food security and livelihoods worldwide but face intensifying pressures from climate change, infectious disease, and inconsistent feed supplies. African and European indigenous cattle provide a natural comparative framework spanning gradients of climate, pathogen burden, and husbandry, and possess genomic mosaics comprising African taurine, European taurine, and indicine ancestry. We analyzed whole-genome sequences from 519 cattle across 24 African and European indigenous populations and 117 publicly available genomes from Africa, Asia, Europe, and the Americas. This dataset reveals admixture mosaics among major lineages and identifies 36 candidate genes exhibiting adaptive retention of ancestral alleles associated with response to heat stress (e.g., HSPA12B, DDIT3), immunity (IRAK3), productivity (ACSF3), and reproductivity (SSMEM1, SPEF1). Our study suggests that historical admixture introduced variation shaped by local ecological selection, clarifying how environmental heterogeneity drives the retention of advantageous alleles and informing sustainable breeding and diversity conservation. - Source: PubMed
Publication date: 2026/03/19
Gao JunxinGinja CatarinaLiu YingKantanen JuhaGhanem NasserKugonza DonaldMakgahlela MahlakoOkwasiimire RodneyBovenhuis HenkGroenen Martien A MCrooijmans Richard P M A