CXCR4 (N-Terminus) Peptide
- Known as:
- CXCR4 (N-Terminus) Peptide
- Catalog number:
- 1009P
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- CXCR4 (N-Terminus) Peptide
Related genes to: CXCR4 (N-Terminus) Peptide
- Gene:
- CXCR4 NIH gene
- Name:
- C-X-C motif chemokine receptor 4
- Previous symbol:
- -
- Synonyms:
- LESTR, NPY3R, HM89, NPYY3R, D2S201E, fusin, HSY3RR, NPYR, CD184
- Chromosome:
- 2q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2019-04-23
Related products to: CXCR4 (N-Terminus) Peptide
Related articles to: CXCR4 (N-Terminus) Peptide
- Extramedullary hematopoiesis is increasingly recognized as an important mechanism by which peripheral tissues augment immune responses during inflammation and infection. However, the mechanisms governing recruitment, retention, and local differentiation of circulating hematopoietic stem and progenitor cells (HSPCs) within human tissues remain poorly understood due to the lack of physiologically relevant experimental models. Here, we developed a human skin-on-a-chip microphysiological platform to investigate the role of circulating hematopoietic stem and progenitor cells (HSPCs) in cutaneous immune responses and their potential contribution to extramedullary hematopoiesis. The device recapitulates key features of human skin, including a perfusable vascular endothelium, fibroblast-populated dermis, and keratinocyte epidermis. Upon stimulation with pro-inflammatory cytokines or a TLR2 agonist, endothelial activation significantly increased ICAM-1 and VCAM-1 expression and enhanced recruitment of both neutrophils (PMNs) and HSPCs. While PMNs readily underwent transendothelial migration into the dermal compartment, HSPCs remained localized to the vascular niche. Notably, HSPCs adhered robustly and persisted on inflamed endothelium independent of SDF-1/CXCR4 signaling. Under granulopoietic conditions, these retained HSPCs differentiated locally within the vascular compartment into PMN-like cells capable of phagocytosis and exhibiting pathogen-responsive gene expression profiles. These findings provide evidence in a human model that circulating HSPCs can contribute to host defense localized granulopoiesis without tissue infiltration, and suggests that the vascular niche itself may serve as a site of immune cell production during infection. The platform further offers a foundation for developing HSPC-based therapeutic strategies to combat antibiotic-resistant skin infections. - Source: PubMed
Publication date: 2026/09/03
Cirves Evan PWallace Stormy KChiaramonte Bella SJudy MadisonShirure Venktesh SShergill Bhupinder SGeorge Steven C - The management of severe diabetic foot ulcers (DFUs) remains a major clinical challenge. Tibial cortex transverse transport (TTT) has emerged as an effective surgical intervention, but its underlying mechanism, particularly concerning stem cell mobilization and signaling pathways, is largely unknown. - Source: PubMed
Publication date: 2026/09/02
Deng BaopingGe XiaoyongLi JunjieDeng Weiping - Drug-target Mendelian randomisation (MR) studies investigate whether genetically proxied modulation of druggable proteins affects the risk of periodontitis, thereby identifying potential pharmacological targets. - Source: PubMed
Publication date: 2026/09/02
Nibali LuigiKang JingHaworth SimonPolizzi AlessandroIsola Gaetano - Cold atmospheric plasma (CAP) has emerged as a promising non-thermal modality with anticancer effects. Combining CAP with immune checkpoint blockade (ICB) may enhance therapeutic efficacy, yet the molecular targets underlying this synergy remain incompletely understood. - Source: PubMed
Rostami ZeinabAkhoundi FatemehYazdani ZahraEslamijouybari MohammadMirzaei MansoorehBousaeedi ForouzanRostami GhazalehRafiei Alireza - Obesity contributes to immune system dysregulation, thereby increasing the risk of developing numerous diseases. Dietary capsaicin (CAP) has been demonstrated to mitigate obesity, while its impact on B cell immunity during obesity remains unexplored. This study aimed to investigate the restorative effect of CAP on B cells deficiency in obese mice, and explore the underlying mechanisms. - Source: PubMed
Publication date: 2026/08/31
Yang ChengyuLiu ZhenyaXiong XiaoweiLi JiayuanZhao WenjiaLiu JianLi SiluLi HuiHang Hengjun