ERP29 Antibody
- Known as:
- ERP29 Antibody
- Catalog number:
- XW-8133
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- ERP29 Antibody
Related genes to: ERP29 Antibody
- Gene:
- ERP29 NIH gene
- Name:
- endoplasmic reticulum protein 29
- Previous symbol:
- C12orf8
- Synonyms:
- ERp28, ERp31, ERp29, PDI-DB, PDIA9
- Chromosome:
- 12q24.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2016-11-09
Related products to: ERP29 Antibody
Related articles to: ERP29 Antibody
- Coronary artery disease (CAD) remains a leading cause of mortality worldwide, with substantial unmet therapeutic needs. This study aimed to identify and prioritize genetically supported therapeutic targets for CAD using Mendelian randomization (MR). - Source: PubMed
Publication date: 2026/02/12
Yan BotengPan PeijiangTao WenfuMo ZengnanLi Mingli - The aim of this study was to investigate gene expressions related to beta cell function, and the altered protein profiles in insulinoma INS-1 cells following DB application, under both cytotoxic and non-cytotoxic conditions, with a focus on cell death and proliferation. Caspase 3 activity, LDH level, Bax, Bcl-2, PCNA, MafA, Nkx6.1, Pdx1, NeuroD1, and Pax6 gene expressions, TOS, TAS, and OSI were demonstrated. Protein profiles were analyzed using LC-MS/MS. The upstream and downstream proteins using the IPA database were determined. ERP29, UBE2V2, UBE2L6, PSMA4, TSMB10, ARF1, NUDCD2, ARF3, IRS1, PTEN, AKT, HSPA8, and Fibronectin levels were shown. The changes were observed in genes depending on pancreatic beta cell function and apoptosis. Bcl2, MafA, Nkx6.1, Pdx1, and NeuroD1 gene levels decreased, while Bax and Pax6 gene levels and TAS and TOS levels increased in the group given STZ + DB. PCNA, Bcl-2, Nkx6.1, Pdx1, and Pax6 gene levels increased, while MafA gene levels decreased in the group given DB. The protein ubiquitination pathway more predominates than the other many signaling pathways. Several proteins not previously associated, or only indirectly linked, with beta cell function, apoptosis, or proliferation were identified and characterized for the first time in insulinoma. These findings provide new insights and potential targets for the treatment of pancreatic cancer. - Source: PubMed
Publication date: 2025/10/22
Karatug Kacar Ayse - High morbidity and mortality associated with human β-coronavirus (CoV) infection highlight the need to determine host responses to infection and develop anti-viral therapies. Gap junction intercellular communication (GJIC), particularly involving Connexin43 (Cx43), is vital for maintaining central nervous system (CNS) homeostasis, and disruption of GJIC is a well-documented pathogenic mechanism among β-coronaviruses. Specifically, murine β-coronavirus, mouse hepatitis virus (MHV-A59) inoculation in the mouse brain causes acute-stage CNS viral spread and chronic neuroinflammatory demyelination while causing pronounced downregulation of Cx43 at the acute stage, reflecting a critical role in CNS pathology. To pharmacologically target Cx43, 4-phenylbutyric acid (4-PBA) has been widely used, since it enhances the expression of ER-resident thioredoxin family protein (ERp29), a molecular chaperone of Cx43. 4-PBA has been shown to have anti-viral effects against MHV-A59 ; however, the efficacy of 4-PBA is unknown. This study investigates the effect of 4-PBA administration on the pathology of MHV-A59 infection . We demonstrate that 4-PBA treatment reduced acute MHV-A59 infectivity and viral spread in the brain while modulating the glial cell response and mounting host immunity. MHV-A59 infection downregulated the expression of ERp29 in the CNS, which was rescued by 4-PBA treatment. Furthermore, treatment with 4-PBA effectively preserved the expression of Cx43 and Cx47 in infected CNS cells, counteracting their infection-induced downregulation. 4-PBA treatment not only limits acute viral replication and spread throughout the brain but also protects against severe chronic virus-induced neuroinflammatory demyelination . These findings highlight 4-PBA's significant anti-viral potential against murine β-CoV and therapeutic potential in mitigating virus-induced neuroinflammatory demyelination.IMPORTANCEPast outbreaks and the emergence of novel coronaviruses pose a serious global health threat, warranting studies on the disease mechanism of these viruses and the development of new anti-viral strategies. In the current study, we demonstrated the antiviral potential of 4-phenylbutyric acid (4-PBA) against a neurotropic murine β-coronavirus, mouse hepatitis virus (MHV-A59). MHV-A59 inoculation in the brain causes virus infection and disruption of gap junction (GJ) communication by the downregulation of GJ proteins connexin 43 (Cx43) and connexin 47 (Cx47), crucial for maintaining CNS homeostasis. We demonstrate that 4-PBA restricts viral spread and infectivity in the mouse brain and improves the reduced levels of ERp29 and, thus, Cx43 and Cx47 in the infected CNS. Furthermore, 4-PBA mitigated virus-induced chronic neuroinflammatory demyelination, the characteristic feature of multiple sclerosis (MS). These findings demonstrate that 4-PBA holds significant therapeutic potential for restricting β-CoV spread and virus-induced neuroinflammatory demyelination. - Source: PubMed
Publication date: 2025/09/08
Kasle GrishmaSharma MadhavKumar SauravDas PranatiDas Sarma SubhajitKoval MichaelKenyon Lawrence CDas Sarma Jayasri - Currently, liver hepatocellular carcinoma (LIHC) is characterized by high morbidity, rapid progression and early metastasis. Although many efforts have been made to improve the prognosis of LIHC, the situation is still dismal. Inability to initiate the process of programmed cell death (PCD) is closely associated with cancer progression, thus influencing patients' prognosis. In this study, our purpose was to construct PCD-related prognostic signature for LIHC patients. - Source: PubMed
Publication date: 2025/08/05
Zhang XiaoxiangDing DongxiaoWang DianqianQin Yunsheng - Several members of protein disulfide isomerase (PDI) family with the CXYC active motif such as PDI, ERp57, ERp72, ERp46, ERp5 and TMX1 have important roles in platelet functions and thrombosis. These members contribute to the network of redox regulation of platelet activities. However, whether other PDI family members without the CXYC motif such as ERp29, have a role in these processes remains unknown. - Source: PubMed
Publication date: 2025/05/07
Yan XiaofengLu YishanLv KeyuJiang MiaoFang ChaoWu YiYang Aizhen