ZA20D3 Antibody
- Known as:
- ZA20D3 Antibody
- Catalog number:
- XW-8065
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- ZA20D3 Antibody
Related genes to: ZA20D3 Antibody
- Gene:
- ZFAND6 NIH gene
- Name:
- zinc finger AN1-type containing 6
- Previous symbol:
- ZA20D3
- Synonyms:
- ZFAND5B, AWP1
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-10
- Date modifiied:
- 2017-01-19
Related products to: ZA20D3 Antibody
Related articles to: ZA20D3 Antibody
- Unexplained recurrent spontaneous abortion (URSA) is a major problem in the field of human reproductive health. At present, several circRNAs have been reported to be differentially expressed and play an important biological function in pregnancy-related diseases. However, the role of circRNAs in URSA remains unclear. - Source: PubMed
Publication date: 2025/04/08
Wang WentingHuang LinxiangLv JuanMiao ZhijingJin ShupingLi ShanCheng Qing - ZFAND6 is a zinc finger protein that interacts with TNF receptor-associated factor 2 (TRAF2) and polyubiquitin chains and has been linked to tumor necrosis factor (TNF) signaling. Here, we report a previously undescribed function of ZFAND6 in maintaining mitochondrial homeostasis by promoting mitophagy. Deletion of ZFAND6 in bone marrow-derived macrophages (BMDMs) upregulates reactive oxygen species (ROS) and the accumulation of damaged mitochondria due to impaired mitophagy. Consequently, mitochondrial DNA (mtDNA) is released into the cytoplasm, triggering the spontaneous expression of interferon-stimulated genes (ISGs) in a stimulator of interferon genes (STING) dependent manner, which leads to enhanced viral resistance. Mechanistically, ZFAND6 bridges a TRAF2-cIAP1 interaction and mediates the recruitment of TRAF2 to damaged mitochondria, which is required for the initiation of ubiquitin-dependent mitophagy. Our results suggest that ZFAND6 promotes the interactions of TRAF2 and cIAP1 and the clearance of damaged mitochondria by mitophagy to maintain mitochondrial homeostasis. - Source: PubMed
Publication date: 2024/12/06
Shaikh KashifBowman MelissaMcCormick Sarah MGao LinlinZhang JiawenWhite JesseTawil JohnKapoor ArunArav-Boger RavitNorbury Christopher CHarhaj Edward W - More than 250 loci have been identified by genome-wide scans for type 2 diabetes in different populations. South Asians have a very different manifestation of the diseases and hence role of these loci need to be investigated among Indians with huge burden of cardio-metabolic disorders. Thus the present study aims to validate the recently identified GWAS loci in an endogamous caste population in North India. - Source: PubMed
Publication date: 2023/09/22
Walia Gagandeep KaurSharma PratikshaAgarwal TriptiLal MotiNegandhi HimanshuPrabhakaran DorairajKhadgawat RajeshSachdeva Mohinder PalGupta Vipin - Circular RNAs (circRNAs) are important regulators in breast cancer progression. However, the underlying mechanism of circRNAs functions in breast cancer remain largely unclear. - Source: PubMed
Publication date: 2023/04/29
Huang XiaojiaTan WeigeLiu ZitengFu XiaoyanLi ZongyanLai ShengqingLi QianZhong XiaofangQu FanliZhang HuayaoLi Haiyan - Prediabetes is a reversible, intermediate stage of type 2 diabetes mellitus (T2DM). Lifestyle changes that include healthy diet and exercise can substantially reduce progression to T2DM. The present study explored the association of 37 T2DM- and obesity-linked single nucleotide polymorphisms (SNPs) with prediabetes risk in a homogenous Saudi Arabian population. A total of 1129 Saudi adults [332 with prediabetes (29%) and 797 normoglycemic controls] were randomly selected and genotyped using the KASPar SNP genotyping method. Anthropometric and various serological parameters were measured following standard procedures. Heterozygous GA of -rs4812829 (0.64; 95% CI 0.47-0.86; < 0.01), heterozygous TC of -rs1801214 (0.60; 95% confidence interval (CI) 0.44-0.80; < 0.01), heterozygous GA of -rs5945326 (0.60; 95% CI 0.39-0.92; = 0.01), heterozygous GA of -rs11634397 (0.75; 95% CI 0.56-1.01; = 0.05), and homozygous AA of -rs11642841 (1.50; 95% CI 0.8-1.45; = 0.03) were significantly associated with prediabetes, independent of age and body mass index (BMI). Additionally, C-reactive protein (CRP) levels in rs11634397 (AA) with a median of 5389.0 (2767.4-7412.8) were significantly higher than in the heterozygous GA genotype with a median of 1736.3 (1024.4-4452.0) ( < 0.01). In conclusion, only five of the 37 genetic variants previously linked to T2DM and obesity in the Saudi Arabian population [-rs4812829, -rs1801214, -rs5945326, -rs11634397, -rs11642841] were associated with prediabetes susceptibility. Prospective studies are needed to confirm the potential clinical value of the studied genetic variants of interest. - Source: PubMed
Publication date: 2023/02/21
Binjawhar Dalal NAnsari Mohammed G ASabico ShaunHussain Syed DanishAlenad Amal MAlokail Majed SAl-Masri Abeer AAl-Daghri Nasser M