UCK2 Antibody
- Known as:
- UCK2 Antibody
- Catalog number:
- XW-8050
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- UCK2 Antibody
Related genes to: UCK2 Antibody
- Gene:
- UCK2 NIH gene
- Name:
- uridine-cytidine kinase 2
- Previous symbol:
- UMPK
- Synonyms:
- -
- Chromosome:
- 1q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: UCK2 Antibody
Related articles to: UCK2 Antibody
- Osteosarcoma typically arises during adolescence, posing a significant challenge. Despite comprehensive treatment strategies encompassing surgery, radiation therapy, and chemotherapy, which can notably enhance long-term survival rates among osteosarcoma patients, the 5-year survival rate for metastatic cases remains discouragingly low. Consequently, early diagnosis and prompt intervention are paramount in improving the prognosis of patients afflicted with this condition. Metabolic reprogramming holds paramount significance in the initiation and progression of tumors. In this meticulous investigation, we devised a risk prediction model that encompasses seven pivotal nucleotide metabolism-related genes: MYC, MUC1, IMPDH1, SAMHD1, NUDT13, UCK2, and NUDT16. This model was formulated leveraging six advanced machine learning algorithms. The results demonstrated that the risk prediction model exhibited robust prognostic predictive capability. Notably, patients identified with a high-risk phenotype exhibited a significantly lower long-term survival rate, coupled with elevated expression of immunosuppressive genes, highlighting the importance of metabolic reprogramming in influencing both survival outcomes and immune status. The multivariate Cox regression analysis confirmed that our model serves as an independent prognostic indicator, significantly impacting the long-term prognosis of osteosarcoma patients. Subsequently, we developed and validated a nomogram, which accurately predicts 1-, 3-, and 5-year survival rates for these patients. Furthermore, we compared chemosensitivity between high- and low-risk groups, gaining valuable insights into potential therapeutic differences. In conclusion, this model demonstrates superior prognostic predictive capability and holds promise in guiding chemotherapy treatment strategies for osteosarcoma patients, thereby enhancing treatment outcomes. - Source: PubMed
Publication date: 2026/05/02
Ju SongliTao LuLi XuyanHuang NijiaoKe Xixian - - Source: PubMed
Publication date: 2026/04/02
Zhao YunFengShen HaoXinSun YiboSong JinKunGuangSun ChenLi JinXiuWang HongYuSong YinSen - Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with poor prognosis. This study identifies metabolism-related genes (MRGs) associated with HCC prognosis, develops a multi-gene prognostic model based on metabolic reprogramming and immune escape, and evaluates their roles in the tumor microenvironment (TME) to guide diagnosis and treatment. - Source: PubMed
Publication date: 2026/03/19
Cai ZihanHuang ChunxiaoYi XiaomeiDing ShoupengGao JinghuaHan Jian - Post-transcriptional RNA modifications are ubiquitous in biology, but the fate of epigenetic ribonucleotides after RNA turnover and the consequences of their metabolism and misincorporation into nucleic acids are largely unknown. Here, we explore epigenetic ribonucleoside metabolism in human cells by studying effects on cell growth, quantifying RNA misincorporation and identifying metabolic regulators, and exploring phenotypes associated with cytotoxicity. We find that bulky N-modified adenosines (i.e., iA) exhibit high levels of cytotoxicity and RNA misincorporation, whereas cells dramatically restrict the misincorporation of small N-modified adenosines (i.e., mA), partly through sanitization by enzymatic deamination, consistent with a recent report. Epigenetic ribopyrimidines also exhibit cytotoxicity, dependent on nucleoside kinase UCK2, but only at much higher concentrations than ribopurines. We further characterize the effects of cytotoxic ribonucleoside metabolism on nucleolar morphology and protein translation. Taken together, our work provides new insights into the metabolism of epigenetic ribonucleosides and mechanisms underlying their cytotoxicity to cells. - Source: PubMed
Publication date: 2026/03/06
Sun XuemengDonlic AnitaBoyer Jacob APress Theodore EKim MinjaeReddy Neal KBrangwynne Clifford PRabinowitz Joshua DKleiner Ralph E - The epidemiological and molecular associations between psoriasis and chronic obstructive pulmonary disease (COPD) remain incompletely elucidated. To explore this association and shared mechanisms, this study integrated data of the National Health and Nutrition Examination Survey (NHANES) 2003–2014 ( = 17,416), assessing this association via multivariable logistic regression and subgroup analysis. Transcriptomic data of psoriasis (skin tissue) and COPD (alveolar macrophages) were retrieved from the Gene Expression Omnibus (GEO) database. Candidate biomarkers were identified via differentially expressed gene (DEG) analysis, weighted gene coexpression network analysis (WGCNA), and machine learning [Random Forest (RF) and least absolute shrinkage and selection operator (LASSO)], followed by validation of their diagnostic efficacy. In the fully weighted and adjusted model, no statistically significant association was found between psoriasis and COPD (OR = 1.25, 95% CI: 0.93–1.68, = 0.14), although trend-level associations were observed among smokers, individuals with hypertension, and those with unstable marital status. We identified 85 shared differentially expressed genes (DEGs), enriched in inflammatory pathways such as the chemokine signaling pathway, and screened three candidate genes (UCK2, P4HA1, and HIBADH). A RF diagnostic model based on these genes achieved Area Under the Curves (AUCs) of 0.935 for psoriasis and 0.962 for COPD in external validation sets. These findings suggest that the comorbidity between psoriasis and COPD may be influenced by risk factors such as smoking and hypertension, as well as shared inflammatory pathways and differentially expressed genes (DEGs) regulation. Psoriasis could serve as a potential window for early COPD screening and provide novel cross-disease therapeutic targets. - Source: PubMed
Publication date: 2026/02/07
He YuFengXiang LinMeiHe YanChengWang GuanJieJiang HuiLiLi YuZeQi XiaoYi