NAPG Antibody
- Known as:
- NAPG Antibody
- Catalog number:
- XW-7977
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- NAPG Antibody
Related genes to: NAPG Antibody
- Gene:
- NAPG NIH gene
- Name:
- NSF attachment protein gamma
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 18p11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-17
- Date modifiied:
- 2016-10-05
Related products to: NAPG Antibody
Related articles to: NAPG Antibody
- The transformation of O is primarily facilitated by the catalytic action of redox enzymes, which play a pivotal role in sustaining cellular energy metabolism and redox balance. Bioinspired by O distribution and ROS regulation related to cascade biocatalytic process, a D-peptide NapGFFY engineered hydrogel has been constructed with encapsulated dual-enzyme superoxide (SOD) and chloroperoxidase (CPO) cascade catalytic circuit and co-assembled photosensitizer of 5-aminolevulinic acid molecules (ALA). Multimodal oxygen modulation has been conducted by the concurrent oxygen generation via SOD-catalyzed ⋅O dismutation and oxygen consumption for O production by CPO and ALA, achieving self-sustaining enzymatic dynamic therapy (EDT)-photodynamic therapy (PDT) (EDT-PDT) synergy. The endogenous cascade-amplified EDT not only enhances the O efficacy in exogenous PDT therapy, but the intermediate O can also alleviate local neuropathic pain caused by hypoxia for safe PDT treatment. This work pioneers enzyme-mediated dynamic control of tumor redox homeostasis, establishing a new therapeutic axis between biocatalytic amplification and photodynamic processes. - Source: PubMed
Publication date: 2025/12/25
Zhang QiZheng ZheZhao YitingWu QingWu ChuWang XiuliWang XiaWang QigangWang Peiru - Pyrite can be used in denitrification systems to improve efficiency. In this study, the role of pyrite and extracellular polymeric substances (EPS) was investigated in biological denitrification. In cultures of Paracoccus denitrificans, pyrite effectively enhanced denitrification efficiency, primarily by increasing key components of electron transport system such as cytochrome c and NADH, and upregulating the expression levels of genes involved in the synthesis of riboflavin and cytochrome c, along with denitrification-critical genes such as nosZ and napG. The denitrification of Paracoccus denitrificans in the presence of EPS exhibited a more complete reduction of nitrate than that in the absence of EPS. Electrochemical analysis revealed that the flavins and cytochrome c within EPS may contribute to electron transfer during denitrification. Riboflavin was reproduced by the cells, despite being removed along with EPS at the initial stage. Both pyrite and extracellular EPS could enhance nitrogen removal by facilitating electron transport processes. - Source: PubMed
Publication date: 2025/08/18
Wang WenhuiTan JiaxiuHua YumeiHu JinlongSun CaixiaLiu GuanglongZhao Jianwei - This study evaluates nanotechnology's application in restoring historical brick facades, specifically focusing on how montmorillonite clay nanoparticle spray effectively fills cracks and pores, thereby reducing porosity and decreasing water absorption. The research methodology involves controlled experiments on both historical and purchased brick samples, assessing the impact of nanospray through water absorption and porosity tests. The study seeks to mitigate surface water penetration to the bricks, as well as to fill the capillary cracks and pores that have formed due to various factors. Results indicate that nanospray successfully fills pores and capillary cracks, reducing water penetration and improving brick durability. When nanoparticles fill these pores and cracks, they effectively reduce the overall porosity and also increase the tortuosity that water vapor must take to pass through the material. By reducing the number and size of pores and making the diffusion path more tortuous, the nanoparticle treatment can increase the water vapor diffusion resistance of the brick. While reducing water absorption is beneficial for protecting the brick from water damages, breadthening of historic masonry is necessary, meaning it must be able to absorb or release moisture by changing the humidity level. Using nanoclays as Nano-Pico Getechnics (NaPG) and Nano-Geotechnics (NaG) techniques can consider the balance between reducing water absorption and maintaining sufficient vapor permeability (breathability). clay nanoparticles can fill the pores without completely blocking them, thus allowing vapor to pass through. This study contributes to advancing sustainable restoration practices to assess the long-term effects and environmental adaptability of nanospray applications. This nanotechnology approach is chosen not only for its high efficiency in protecting brick facades but also for its economic viability and environmental compatibility, classifying it as a form of "green restoration" or "sustainable restoration". - Source: PubMed
Publication date: 2025/08/18
Biabani RezaNiroumand HamedAfsharpour MaryamKhaksar Mona - The association between oxidative stress and osteoporosis (OP) has been substantiated by numerous studies; however, the precise underlying mechanism remains elusive. Hence, we employed bioinformatics methodologies to investigate this phenomenon. OP-related datasets (GSE56815 and GSE7158) were utilized in this study. Key module genes linked to oxidative stress-related genes (OS-RGs) were acquired through weighted gene coexpression network analysis (WGCNA). By crossing key module genes and differentially expressed genes (DEGs) from differential expression analysis, candidate genes were obtained. Subsequently, diagnostic genes were obtained through receiver operating characteristic (ROC) curve analysis and expression evaluation. Furthermore, a nomogram model was developed utilizing these genes to assess the collective predictive capacity of the diagnostic genes for OP comprehensively. Additionally, gene set variation analysis (GSVA), immune analysis, and construction of a molecular regulatory network were implemented to further understand the mechanism of the diagnostic genes in OP. We also preliminarily verified the effect of NAPG on osteogenic differentiation through experiments such as ALP, ARS and Western Blot. A total of 101 candidate genes were identified by crossing 395 DEGs and 1,730 key module genes. Importantly, NAPG, NCOA1, and TRIM44 were identified as diagnostic genes associated with oxidative stress in OP. The nomogram model showed the potential predictive ability of OP. Moreover, the GSVA results demonstrated that low expression of NAPG, NCOA1, and TRIM44 was enriched in the oestrogen response early signalling pathway. Moreover, these diagnostic genes were strongly correlated with multiple immune-related genes in the two datasets. Additionally, we identified several important factors that have regulatory relationships with diagnostic genes, such as MEF2A, STAT3, YY1, CREB1, hsa-mir-132-3p, and hsa-mir-148a-3p. Finally, it was verified at the protein and cellular levels that NAPG inhibits osteogenic differentiation and may play a crucial role in osteoporosis. NAPG, NCOA1, and TRIM44 were found to be associated with the diagnosis of OP, suggesting novel opportunities for diagnosing and treating OP. - Source: PubMed
Publication date: 2025/07/02
Liu ZhenchuanYang XuWang ZexinLi QiGu HanwenMeng QunboZhang Yuanqiang - Frailty refers to a state of increased vulnerability to mortality and other adverse outcomes as a consequence of age-related decline in physiologic reserve and function. Comparative biomedical scientists are relied upon to innovate approaches to enhance understanding of the similarities and differences between humans and other animal species that can impact healthy aging. The research aim of this study was to develop a clinical frailty index (FI) in the Exceptional Aging in Rottweilers Study (EARS) and test its ability to predict all-cause mortality in elderly dogs. EARS is an ongoing lifetime cohort study of pet dogs with extreme longevity living in North America. Living 30% longer than the breed average, these dogs represent the canine counterpart to human centenarians. A 34-item FI (EARS-FI) was constructed to assess deficit accumulation using clinical data collected by telephone interviews with owners of 93 dogs with extreme longevity. Health deficits across multiple domains, including cognitive and sensory, cardiovascular and endocrine, and mobility, were included. The association between EARS-FI and subsequent mortality was tested in Kaplan-Meier survival analysis and in age-adjusted Cox proportional hazard models. Median (interquartile range) EARS-FI was 0.43 (0.38-0.50), and the estimated frailty limit was 0.68, consistent with data reported in humans with extreme longevity. Frailty index increased with increasing chronological age ( < 0.001). Deficit accumulation was significantly associated with increased mortality risk. Age-adjusted hazard ratio for mortality per 0.01 unit increase in FI was 1.05 (95%CI, 1.02-1.08; = 0.001). This work provides the first demonstration of a strong association between frailty and mortality risk in pet dogs with extreme longevity. Notably, EARS-FI showed key features observed in the evaluation of frailty in aging human populations: heterogeneity, increase with chronological age, and estimated limit of <0.7. Validated here as a predictor of mortality in aged pet dogs, EARS-FI offers a useful tool for further comparative analyses of the linkages between deficit accumulation, mortality, and other adverse health outcomes. - Source: PubMed
Publication date: 2024/12/18
Waters David JMaras Aimee HFu RongCarrillo Andres EChiang Emily CSuckow Cheri L