CTSH Antibody
- Known as:
- CTSH Antibody
- Catalog number:
- XW-7949
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- CTSH Antibody
Related genes to: CTSH Antibody
- Gene:
- CTSH NIH gene
- Name:
- cathepsin H
- Previous symbol:
- CPSB
- Synonyms:
- ACC-4, ACC-5, ACC4, ACC5
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-02-16
Related products to: CTSH Antibody
Related articles to: CTSH Antibody
- This study aimed to systematically evaluate the potential causal relationship between plasma and cerebrospinal fluid protein levels and sepsis risk through the integration of Mendelian randomization (MR) analysis, external validation, and Bayesian colocalization analysis. It further sought to explore the genetic mechanisms of key proteins and their potential as drug targets. We performed two-sample MR to screen plasma and cerebrospinal fluid proteins for genetic associations with sepsis. The main findings were then evaluated using independent datasets for external validation and assessed for shared causal variants with sepsis using Bayesian colocalization. Network and drug-database analyses were conducted as exploratory functional annotations. The MR analysis initially identified 3 key proteins - CTSH, IL6R, and OLFM1 - with higher genetically predicted CTSH levels associated with increased sepsis risk, supported by external validation (Primary: odds ratio = 1.10, 95% confidence interval = 1.03-1.17, P = .004; SameVariant: odds ratio = 1.07, 95% confidence interval = 1.02-1.13, P = .004). Colocalization analysis indicated that the genetic correlation between CTSH and sepsis was relatively low (PP.H4.abf = .0585). The protein-protein interaction network revealed that CTSH is closely linked to various immune-related genes. Genomics of Drug Sensitivity in Cancer database analysis suggested that CTSH may be targeted by existing drugs, indicating its potential for drug intervention. CTSH shows a consistent genetic association with sepsis risk, but colocalization provides only weak evidence for a shared causal variant, so the overall genetic support is modest. Further functional and clinical validation is needed before considering CTSH for therapeutic translation. - Source: PubMed
Du YangwenZhou LingyaoHuang BoWenLu FengJin QinLin Guo - Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal immune dysregulation and mucosal barrier dysfunction. Macrophages play central roles in gut immunity, yet their metabolic reprogramming and heterogeneity in UC remain insufficiently characterized. - Source: PubMed
Publication date: 2026/09/03
Zhang RuiZhang HuifangWang ZhifengWang YonggangJia Zhongwei - Routine clinical data offer significant potential for data-driven research and real-world evidence. However, such data are typically heterogeneous, irregular, and not designed for research use. This has a detrimental effect on the transformation of the data into analysis-ready datasets. The following paper sets out a preprocessing framework that converts routine clinical data into research-ready datasets. The approach was developed in the context of a use case concerning kidney transplant rejection diagnostics, with the objective of reconstructing clinically meaningful treatment trajectories. The proposed framework is comprised of three distinct steps: firstly, recursive event classification (rEC), then context-sensitive event annotation (cEA), and finally, context-based time series harmonisation (cTSH). The purpose of the framework is to transform irregular measurements into standardised temporal representations. When applied to routine data, the framework generated structured, comparable datasets that resemble clinical study data. These enable statistical modelling, machine learning, and systematic data reuse. - Source: PubMed
Katzensteiner MatthiasLiehr DarianBott Oliver J - Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology. - Source: PubMed
Picard CynthiaAumont-Rodrigue GabrielSarty IsabelLoncke JuliaSavard MélissaMaligne-Bruneau LaurencePoirier Judes - The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mechanisms are limited. We integrated genomic and proteomic analyses to investigate sex-specific associations of the plasma-proteome with CAD. - Source: PubMed
Publication date: 2026/09/03
Sier Vincent QDimitrova KristinaPeters Erna H A Bvan der Loo Wouter P MWillems van Dijk Kovan Heemst DianaBax Wilhelmina HQuax Paul H APasterkamp GerardMokry MichalJukema J WouterNoordam Raymondde Vries Margreet R