PDAP1 Antibody
- Known as:
- PDAP1 Antibody
- Catalog number:
- XW-7944
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- PDAP1 Antibody
Related genes to: PDAP1 Antibody
- Gene:
- PDAP1 NIH gene
- Name:
- PDGFA associated protein 1
- Previous symbol:
- -
- Synonyms:
- PAP1, PAP, HASPP28
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-15
- Date modifiied:
- 2016-10-05
Related products to: PDAP1 Antibody
Related articles to: PDAP1 Antibody
- Lactylation is a posttranslational modification involved in cellular metabolic and immune processes. Although dysregulated lactate metabolism has been implicated in type 1 diabetes (T1D), the genetic relevance of lactylation-related molecular traits remains poorly defined. - Source: PubMed
Ding YuGao ShiyangYing LingwenTang JieChang GuoyingHuang YiguoYu TingtingLi XinWang Xiumin - This study was to investigate the role of exosomes derived from distal airway stem cells (DASC) in apoptosis of pulmonary vascular endothelial cells (PVEC) in chronic obstructive pulmonary disease (COPD) and to explore the potential mechanisms. - Source: PubMed
Publication date: 2026/06/25
Song QingLiu CongLin LingZhou AiyuanLi TaoZhang PingZeng YuqinChen Ping - Acute lung injury (ALI) remains a lethal clinical challenge driven by an uncontrolled "cytokine storm" resulting from dysregulated inflammatory networks. The metabolic and molecular mechanisms orchestrating this process remain incompletely understood. - Source: PubMed
Publication date: 2026/05/11
Tang HexiaoSong CongkuanCorreia GuiomarLi ChangshengLiu DaoquanZhou Xuefeng - Hepatocellular carcinoma (HCC) exhibits aberrant lipid metabolism, notably increased de novo fatty acid synthesis and reduced fatty acid oxidation. PDAP1, a cancer-associated RNA-binding protein, is overexpressed in multiple malignancies, yet its specific contribution to fatty acid metabolic reprogramming and HCC progression remains undefined. - Source: PubMed
Publication date: 2026/03/14
Li JiazhengKong XiangxuSun HuaibinGuo XiuwenZhou HuaxinGuan ZhengyaoLu KangpingYin ZhaoqingLi YixinDu GangZhang HaoJin Bin - Platelet-derived growth factor associated protein 1 (PDAP1) is implicated in various biological processes, including tumorigenesis and the apoptosis of mature B lymphocytes. However, its functions in organismal development and homeostasis remain poorly understood. To address this gap, we generated Pdap1 knockout mice to elucidate the physiological functions of PDAP1 in vivo. Notably, our findings indicate that the absence of Pdap1 results in early embryonic lethality by embryonic day 11.5, accompanied by a spectrum of developmental abnormalities, including growth retardation, enlarged pericardium, hemorrhage within the pericardial cavity, and impaired vascularization of the yolk sac and placental labyrinth. Analysis of PDAP1 expression during embryogenesis revealed its presence in both embryonic and extra-embryonic tissues, a spatial pattern that may underlie the vascular defects observed in the yolk sac and placenta. Comparative proteomic profiling further identified nidogen-1 (NID1) as a key PDAP1-repressed target. Mechanistically, loss-of-function and gain-of-function experiments demonstrated that NID1, at least in part, mediates PDAP1-modulated endothelial cell migration, invasion, and tube formation-critical processes in vascular morphogenesis. - Source: PubMed
Yang TingWang Shi-JieChao Zhu-JunTian Ruo-FeiFu XinFan Xin-YuChen Zhi-NanLi LingCui Hong-Yong