MGLL Antibody
- Known as:
- MGLL Antibody
- Catalog number:
- XW-7936
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- MGLL Antibody
Related genes to: MGLL Antibody
- Gene:
- MGLL NIH gene
- Name:
- monoglyceride lipase
- Previous symbol:
- -
- Synonyms:
- HU-K5, MGL
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-12-13
- Date modifiied:
- 2016-10-05
Related products to: MGLL Antibody
Related articles to: MGLL Antibody
- Post-traumatic headache (PTH) is a debilitating neurological sequela of mild traumatic brain injury (mTBI) characterized by secondary cephalic pain. The endocannabinoid system (ECS) is a critical modulator of nociception, yet the specific spatiotemporal changes in its metabolic machinery within cephalic pain circuits following mTBI are poorly understood. - Source: PubMed
Publication date: 2026/04/11
Nagarajan GurueswarZhang Yumin - Glyphosate, one of the most widely used herbicides worldwide, has raised significant concerns regarding its potential involvement in hepatotoxicity and molecular changes associated with liver cancer biology. These concerns highlight the need to better understand its underlying molecular mechanisms in hepatoma cells. Emerging evidence suggests that glyphosate exposure may increase the risk of liver cancer and chronic liver disease. However, the precise molecular alterations and promising biomarkers associated with glyphosate-induced hepatic toxicity and disease remain largely unexplored. In this study, an RNA-Seq-based in silico systems biology approach was employed to elucidate glyphosate-induced differential transcriptional profiling in hepatoma cells. This analysis revealed significant transcriptional profiling characterized by the upregulated hub genes and . These genes were primarily associated with glucose metabolism, TNF-α/NF-κB signaling, epithelial-mesenchymal transition (EMT) and cellular stress responses. Conversely, several key genes were significantly downregulated, including , , , , , , , , and , which were involved in lipid metabolism, immune regulation and non-alcoholic fatty liver disease (NAFLD) pathways. Notably, all hub genes demonstrated strong diagnostic performance, highlighting their potential as sensitive biomarkers of glyphosate exposure. Collectively, this study provides comprehensive insights into gene expression changes associated with glyphosate exposure in hepatoma cells, linking them to hepatic metabolic dysregulation and immune modulation and suggesting a panel of hub genes with potential diagnostic and therapeutic significance. - Source: PubMed
Publication date: 2026/03/19
Mishra Divya - Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation, inflammation, and metabolic dysregulation. The endocannabinoid system (ECS), particularly the cannabinoid-1 receptor (CBR), regulates renal metabolism and inflammatory signaling, yet its role in ADPKD remains largely unexplored. - Source: PubMed
Publication date: 2026/03/16
Betkar ShridharNemirovski AlinaRuppo ShmuelHinden LiadTam Joseph - The endocannabinoid system (ECS) is involved in regulating immune functions in leukocytes. An inflammatory stimulus, specifically LPS, can modulate the activity of endocannabinoids (eCB) receptors, and eCB within the leukocytes can further exert either pro- or anti-inflammatory effects on the immune function of these cells. The effects of exogenous eCB on the cellular inflammatory responses of bovine leukocytes are largely unexplored; therefore, we aimed to evaluate the effects of incubation with the main eCB -arachidonoylethanolamide (AEA/anandamide) or 2-arachidonyglycerol (2-AG) on gene expression of eCB and inflammatory mediators following an ex vivo LPS challenge in dairy cow leukocytes. To this end, whole blood from mid-lactation dairy cows (n = 6) were subjected to ex vivo incubation with eCB (control [CTL], AEA at 0.29 µ, or 2-AG at 0.26 µ) for 2 h, followed by stimulation with or without LPS (10 ng/mL) for an additional 2 h. Overall, there were 6 treatments for cells from each cow: CTL, AEA, and 2-AG without LPS stimulation, and CTL+LPS, AEA+LPS, and 2-AG+LPS. Subsequently, RNA was extracted from leukocytes and assayed for gene expression levels via real-time quantitative PCR. First, we examined the main effects of LPS stimulation across eCB treatments: LPS decreased expression of the eCB receptors cannabinoid receptor 2 (), G protein-coupled receptor 55 (), and peroxisome proliferator-activated receptor gamma (). Furthermore, LPS increased expression of the eCB enzymes N-acyl phosphatidylethanolamine phospholipase D () and monoglyceride lipase () while reducing the expression of diacylglycerol lipase B () compared with non-LPS-stimulated groups. Then, we examined the main effects of eCB treatments on gene expression: incubation with AEA increased expression of cannabinoid receptor 1 () in leukocytes, whereas 2-AG increased the expression of the and tended to increase . In addition, 2-AG increased the expression of fatty acid amide hydrolase () and tended to increase the expression of . As expected, LPS increased the expression of inflammatory markers; however, incubation with eCB had no discernible effects on these genes. Taken together, ex vivo exposure of dairy cow leukocytes to AEA or 2-AG, with or without stimulation with LPS, resulted in differential effects on the expression of eCB receptors and enzymes, but we did not detect effects of exogenous eCB on the expression of inflammatory genes following an LPS challenge. The findings of the present study provide the first reductionist step in understanding the relationship between the ECS and inflammatory responses in immune cells of dairy cows. The complexity of the regulation of immune function in leukocytes, and its potential interplay with eCB, requires further studies to comprehensively elucidate the cellular mechanisms underlying these responses. - Source: PubMed
Publication date: 2025/12/13
Dos Santos Silva PButenko YHubner LShattenstein BZachut M - The Tibetan pig, a highland breed with exceptional adaptability to harsh environments (cold, hypoxia, coarse feed) but poor growth/reproductive traits, was studied to uncover genetic mechanisms and support breeding improvements. - Source: PubMed
Publication date: 2026/02/05
Duan MengqiZhang SongyuanJiao HangShang PengLi ChunliWang Kejun