MGLL Antibody
- Known as:
- MGLL Antibody
- Catalog number:
- XW-7936
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- MGLL Antibody
Related genes to: MGLL Antibody
- Gene:
- MGLL NIH gene
- Name:
- monoglyceride lipase
- Previous symbol:
- -
- Synonyms:
- HU-K5, MGL
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-12-13
- Date modifiied:
- 2016-10-05
Related products to: MGLL Antibody
Related articles to: MGLL Antibody
- Meat quality is an important economic trait in beef cattle and is influenced by breed-related metabolic characteristics. Yanbian cattle (YB) are valued for desirable meat quality, whereas Yanhuang cattle (YH), developed using Limousin cattle as the paternal line and Yanbian cattle as the maternal line, exhibit improved growth performance and carcass yield. However, the molecular basis underlying metabolic variation between these two genetically related cattle populations remains unclear. In this study, longissimus thoracis muscle samples from six animals per breed were analyzed using LC-MS/MS-based metabolomics and GC×GC-TOF/MS-based volatile compound profiling, and a subset of three samples per breed from the same cohort was selected for transcriptomic sequencing. A total of 1697 metabolites were detected. Based on the screening criteria of VIP > 1 and < 0.05, 202 candidate metabolites were identified, among which 11 remained statistically significant after false discovery rate (FDR) correction. Volatile compound profiling detected 1333 and 1516 compounds in YB and YH, respectively, of which 809 were shared. Based on the same screening criteria, 39 candidate volatile compounds were identified, although none remained significant after FDR correction. Transcriptomic analysis identified 360 differentially expressed genes using |logFC| > 1 and adjusted < 0.05, with enrichment mainly observed in pathways associated with carbohydrate metabolism, lipid turnover, and energy utilization. Integrative analyses indicated that amino acid-related metabolites, including phenylpyruvate, 2-aminobenzoic acid, and asparagine, were more closely associated with candidate volatile compounds than metabolites involved in central carbon metabolism. Several genes involved in lipid metabolism, energy metabolism, and muscle structure, including , , , , , , , and , were associated with distinct metabolic modules. These findings provide an exploratory view of breed-related metabolic variation and identify candidate molecular features for future validation. - Source: PubMed
Publication date: 2026/08/10
Lyu YangZhu ZhiweiZhao BaoxinRen ZezhuZhou MengYu JingDing HeLiu HongyuFang YiZhao JingLyu Wenfa - Lamivudine and abacavir are key components of first-line paediatric antiretroviral therapy (ART). Rifampicin is part of drug-sensitive TB treatment in children. Rifampicin induces UDP-glucuronosyltransferases and renal transporters and inhibits gastrointestinal transporters involved in the pharmacokinetics of abacavir and lamivudine, but pharmacokinetic data on this potential interaction in infants are scarce. - Source: PubMed
Beca Laize Sílvia Dos Anjos BotasMumbiro VivianBwakura MutsaMujuru Hilda AMudzingwa ShepherdTagarro AlfredoDomínguez-Rodríguez SaraMusiime VictorNalwanga DamalieBuck W ChrisSacarlal JahitChabala ChishalaChansa Bwendo NdunaRojo PabloBurger David MMoraleda CintaJacobs Tom G - Osteoarthritis (OA) is a chronic, progressive joint disorder with higher prevalence and pain severity in women than men. The endocannabinoid system (ECS) modulates pain and shows sexual dimorphism, yet sex-specific alterations in central ECS signalling in OA pain remain under-investigated. - Source: PubMed
Publication date: 2026/07/19
Ferdousi Mehnaz IInfantino RosmaraRedmond Maria CKrishnan Santhosh DAdjei Canny KMcDermott BarryLiddy AlisonQuinlan LeoO'Halloran MartinFinn David P - The aim of this study was to investigate the effects of cannabidiol (CBD) on memory deficits induced by ovariectomy and to directly compare its effects with those of hormone therapy, in order to better understand potential shared mechanisms related to menopause-associated cognitive decline, with a particular focus on the endocannabinoid system. Three-month-old female Wistar rats were randomly assigned to four experimental groups: SHAM-Veh (Vehicle), OVX-Veh, OVX-E2 (estradiol), and OVX-CBD. Animals underwent either bilateral ovariectomy or sham surgery. Following a three-week recovery period, rats received daily subcutaneous injections of CBD (10 mg/kg), estradiol (10 μg/kg), or vehicle for 21 consecutive days. Behavioral assessments included object recognition and fear-motivated memory tests. Twenty-four hours after the final treatment, animals were euthanized for neurochemical and molecular analyses. Levels of the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were measured using high-performance liquid chromatography. Gene expression of cannabinoid receptors CB1 and CB2, as well as enzymes involved in the synthesis and degradation of endocannabinoids (NAPE-PLD, DAGL-A, FAAH, and MGLL), was evaluated in the hippocampus by RT-qPCR. The results demonstrated that CBD treatment produced memory improvements in the object recognition task comparable to those observed with estradiol. Ovariectomy-induced impairments in fear-motivated memory were completely reversed by both CBD and estradiol treatments. Additionally, CBD reduced the expression of FAAH and MGLL, resulting in increased hippocampal levels of AEA and 2-AG, effects similar to those observed with hormone therapy. Estradiol also increased NAPE-PLD expression, contributing to elevated AEA levels. Overall, the findings suggest that CBD exerts a protective effect on memory comparable to standard estrogen therapy, supporting its therapeutic potential for menopause-related cognitive impairments. - Source: PubMed
Caruso Fernanda BorsattoSevero Maria Paula ArakakiColucci Anna Clara MachadoVuaden Beatriz Cristina WeidleKowalski LayzaSchonhofen PatríciaFranke Felipe Schroederde Mello Fernanda Bastosda Silva Rodrigues FernandaGuedes Renata Padilhade Lima Maria Noêmia MartinsHallak Jaime E CZuardi Antônio WaldoCrippa José Alexandre SSchröder Nadja - Orthoflavivirus infection is intricately linked to host cell lipid metabolism, yet the function of bioactive lipids as regulators of infection remains to be elucidated. Here, we investigated the role of lipid mediator pathways, namely ALOX/COX enzymes and upstream lipases, in orthoflavivirus replication by comparing dengue virus (DENV), Zika virus (ZIKV), wild-type yellow fever virus (YFV-Asibi), and the live-attenuated vaccine strain YFV-17D. DENV, ZIKV, and YFV-Asibi, but not the vaccine strain, induced COX2 expression in Huh7 hepatoma cells, correlating with prostaglandin E2 (PGE2) levels in culture supernatants. All four viruses replicated more efficiently in COX2-, ALOX15-, and MGLL-deficient cells, indicating a broadly antiviral role for these enzymes. In contrast, DENV and ZIKV specifically induced ALOX12 expression and depended on ALOX12 for efficient viral RNA replication, as demonstrated by reduced genome copy numbers, altered dsRNA replication compartment morphology, and decreased infectious titers in ALOX12-depleted cells. Direct measurement of lipid peroxidation revealed that ZIKV infection markedly elevated lipid peroxide levels through both ALOX12-dependent and -independent mechanisms, whereas DENV infection did not cause detectable lipid peroxide accumulation. Consistent with this, the ferroptosis inhibitor ferrostatin impaired DENV replication, while the ferroptosis inducer erastin enhanced it; this proviral effect of erastin was fully abolished by ALOX12 knockdown, indicating that DENV depends entirely on ALOX12-driven lipid peroxidation. Iron chelation reduced both DENV and ZIKV infection, confirming a requirement for iron-dependent oxidative processes. The proviral role of lipid peroxidation extended beyond hepatoma cells, as ferrostatin treatment significantly reduced DENV and ZIKV infection in human microglia cells. Our results reveal virus-specific exploitation of lipid peroxidation pathways by orthoflaviviruses and identify ALOX12-dependent lipid peroxidation as a novel proviral mechanism that may represent a target for antiviral intervention. - Source: PubMed
Publication date: 2026/07/08
Vu Kim Chi ThiGrande Yvonne FBierau LauraSchauflinger MartinSpremberg EmiliaKu Joanne Wei KayHehner JuliaSchöbel AnjaHerker Eva