GSTZ1 Antibody
- Known as:
- GSTZ1 Antibody
- Catalog number:
- XW-7920
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- GSTZ1 Antibody
Related genes to: GSTZ1 Antibody
- Gene:
- GSTZ1 NIH gene
- Name:
- glutathione S-transferase zeta 1
- Previous symbol:
- -
- Synonyms:
- GSTZ1-1, MAAI, MAI
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2015-09-11
Related products to: GSTZ1 Antibody
Related articles to: GSTZ1 Antibody
- The glutathione S-transferase (GST) family is essential for detoxification and protection against oxidative stress. Genetic polymorphisms in GST genes, especially non-synonymous single nucleotide polymorphisms (nsSNPs), can influence enzymatic activity and disease susceptibility. This study examines GST nsSNP diversity and functional implications in two Malaysian populations: Malays and the indigenous Orang Asli. Whole genome sequences from 105 Orang Asli and 96 Malays were analyzed using GATK HaplotypeCaller, with functional annotation from Variant Effect Predictor (VEP), SIFT, and PolyPhen-2. Population-specific allele frequencies were compared with global datasets. The structural and functional impacts of deleterious nsSNPs were assessed using I-Mutant, Jalview, I-TASSER, MutPred2, and molecular docking simulations (PyRx and Discovery Studio Visualizer). A total of 3406 SNPs (22 nsSNPs) were identified in Orang Asli and 3291 SNPs (49 nsSNPs) in Malays. Functional predictions indicated that 9 nsSNPs in Malays and 4 in Orang Asli were likely deleterious. The Orang Asli-specific rs147931601 (GSTA1; 3.8%) and Malay-specific rs368356556 (GSTA2; 2.1%) variants were absent in other populations, indicating population-specific adaptations. Stability and conservation analyses revealed that variants such as R155Q (GSTA1), P110S (GSTA2), G144R (GSTA2), D147Y (GSTP1), and E32K (GSTZ1) have high predicted structural or functional damage. Molecular docking showed altered ligand-binding affinities in mutant proteins, potentially affecting detoxification efficacy. This study highlights the genetic uniqueness and functional consequences of GST polymorphisms in Malays and Orang Asli. Population-specific and potentially deleterious variants underscore the need for inclusive genomic research in underrepresented ethnic groups, informing future studies on health disparities and advancing precision medicine in Southeast Asia. - Source: PubMed
Publication date: 2026/03/27
Shirat Aishah FarlianiZaid Muhammad Yusuf AbdulHashim Nurul Azmir AmirIkbal Nurul Huda MohamadNoorizhab Mohd Nur FakhruzzamanSeow Eng KengZahrin Mohammad Masrin MdDarumalinggam Thane MozeHisham Muhammad Danish BadrulKek Teh LaySalleh Mohd Zaki - Spinal cord injury (SCI) significantly impacts patients, with mitochondrial dysfunction playing a critical role in its pathology. Identifying mitochondria-related genes may offer new therapeutic and prognostic insights. - Source: PubMed
Chen HaifengCai WeiZhang YunpengTang XiaomingDai JianLi YaoMa Jian - Prostate adenocarcinoma (PRAD) is a common malignancy in the male genitourinary system, with growing evidence linking its progression to mitochondrial function and macrophage polarization. This study identifies prognostic genes associated with these factors in PRAD through integrated transcriptomic data analysis and Mendelian randomization (MR). - Source: PubMed
Publication date: 2025/12/31
Heng LiBian HaoZhao ChengjunWei ZhenCao JianchengWang Guanfeng - Astaxanthin has attracted considerable interest, owing to its potent antioxidant and pigmentation properties. To investigate its effects of astaxanthin on body color variation in , fish were divided into a control group and a treatment group fed an astaxanthin-supplemented diet. Body color parameters, growth performance, and liver antioxidant enzyme activities were measured at the end of the experiment. Tissues, including skin, intestine, liver, and blood, were subsequently collected for transcriptome sequencing. The results demonstrate that the astaxanthin-treatment group exhibited significantly enhanced body coloration alongside improved body length, body weight, and specific growth rate compared to the control group ( < 0.05). Specifically regarding the red-green value (a*), the treatment group showed significantly higher values on the ventral skin, dorsal skin, and gill cover ( < 0.05). The yellow-blue (b*) and lightness (L*) values were also significantly elevated in the ventral skin and gill cover ( < 0.05), although no significant differences were observed in the dorsal skin ( > 0.05). The skin was identified as the tissue with the highest total carotenoid content. Astaxanthin supplementation enhanced liver antioxidant capacity, evidenced by significantly elevated total superoxide dismutase (T-SOD) activity and significantly reduced malondialdehyde (MDA) levels in the treatment group ( < 0.05). Catalase (CAT) activity did not differ significantly between groups ( > 0.05). Transcriptomic analysis identified several coloration-associated genes, such as bco1, bco2, gstt1, and gstz1. It also revealed significant enrichment in key metabolic pathways (fatty acid, cholesterol, and retinol metabolism) and signaling pathways (PPAR and PI3K-Akt). Furthermore, the expression of multiple solute-carrier family members and apolipoproteins was detected, with notable enrichment in lipid digestion and absorption, cholesterol metabolism, and several key immune-related signaling pathways. These findings provide a theoretical basis for understanding the molecular mechanisms of carotenoid-mediated pigmentation in . - Source: PubMed
Publication date: 2025/11/10
Song LeiChen ZizhaoLai ZhuoxinFeng WenjunWang ZhongduoGuo Yusong - This study aims to provide potential biomarkers and reveal the molecular mechanism of sudden coronary death (SCD). Rat models of atherosclerotic death (ASD), coronary atherosclerosis (AS), and acute myocardial ischemia (AMI) and sham groups were established via the gavage of high-fat emulsion and left coronary artery ligation. The myocardium was collected, and transcriptome sequencing was performed. Differentially expressed miRNAs (DEmiRNAs) were identified using edeR software. The target genes were predicted using TargetScan, and functional enrichment analysis was performed via KEGG. Then, an miRNA-mRNA interaction network was constructed using Cytoscape. The key miRNAs with biomarker potential were identified using LASSO regression. A total of 217, 224, and 86 DEmiRNAs were identified in the ASD, AS, and AMI groups compared with the sham group, respectively. The Ras and Rap1 pathways were mainly expressed in ASD. The β-alanine and sphingolipid metabolisms were expressed in AMI. Finally, miR-106b, miR-195, miR-33, miR-652, miR-466b, and miR-6321 were identified as biomarkers of ASD. MiR-205, miR-877, miR-325, and miR-344b were identified as biomarkers of AMI. miR542-Atg12 was involved in the RIG-I-like receptor signaling pathway, miR6328-Gstz1 was involved in tyrosine metabolism, and miR483-Dusp5 was involved in the MAPK signaling pathway. This study provides a reference for the identification of SCD in forensic pathology. - Source: PubMed
Publication date: 2025/10/28
Zhao ChunmeiZhou XinyuBai YaqinZhao ZhenxiangZhang HuapingGao CairongYun KemingGuo Xiangjie