HSPBP1 Antibody
- Known as:
- HSPBP1 Antibody
- Catalog number:
- XW-7910
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- HSPBP1 Antibody
Related genes to: HSPBP1 Antibody
- Gene:
- HSPBP1 NIH gene
- Name:
- HSPA (Hsp70) binding protein 1
- Previous symbol:
- -
- Synonyms:
- HspBP1, FES1
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 2008-12-04
- Date modifiied:
- 2016-06-21
Related products to: HSPBP1 Antibody
Related articles to: HSPBP1 Antibody
- Necroptosis has been definitively confirmed as a caspase-deficient, non-apoptotic cellular mechanism that exhibits a profound connection to inflammatory disorders. The receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like protein (MLKL Cys86) have been recognized as three main targets for necroptosis for many years. Here, we report HSPBP1 Cys201 and MLKL Cys184 as new cellular targets for necroptosis in human cells. Parthenolide, a natural sesquiterpene lactone, was first confirmed to have anti-necroptotic activity and effectively alleviated the necroptosis-induced systemic inflammatory response syndrome and abdominal aortic aneurysm (AAA) in mice. In the elastase-induced mouse AAA model, MLKL deficiency is highlighted as attenuating AAA formation. HSPBP1 Cys201 was identified to be an upstream target contributing to the anti-necroptotic activity. Co-incubated with purified HSPBP1, followed by mass spectrometry analysis, confirmed that PTL binds to HSPBP1 at Cys201, while HSPBP1 knockdown conferred a certain degree of resilience to necroptosis. Human MLKL Cys184 was discovered as another novel anti-necroptotic target in human HT-29 cells. The human MTRP and molecular dynamics results suggested that Cys184 is the potential binding site between PTL and MLKL. Our co-incubation experiments of PTL with MLKL further demonstrated that PTL can interact with the sulfhydryl group of MLKL Cys184 via covalent modification. These findings yield important insights into the complex regulatory mechanisms of necroptosis and, concurrently, underscore the therapeutic potential of PTL and its derivatives for treating AAA. - Source: PubMed
Publication date: 2026/04/22
Shao HongmingWu JiabinHan QianyuXu LijuanDai PengchengWang RuiLi JiaoWu WenbinHao YananHou RuilinChai YueCheng ZhiWang PeiXue LeiHan TingZhuang Chunlin - - Source: PubMed
Publication date: 2026/04/03
Anisha J PShynu MRadhika GBeena VUma RLijo JAsaf V N MuhasinGleeja V L - Small round cell tumors (SRCT) affecting soft tissue and bone are a distinct category of malignancies. These lesions frequently exhibit similar clinical and radiologic features, may harbor overlapping histologic and immunophenotypic features, and generally have distinct prognostic outcomes. Therefore, in some instances, the diagnosis and accurate subclassification require molecular confirmation. We aimed to provide a comprehensive overview of the morphologic, immunohistochemical, and molecular features of SRCTs of soft tissue and bone in pediatric and young adult patients, with an emphasis on both commonly encountered tumors and rare, recently described entities, accompanied by illustrative material from our TruSight platform. The literature data were mined from the PubMed/Medline, Scopus, and Cochrane databases covering the period from January 1, 2014, to December 31, 2024, and the authors' personal experience with diagnostic cases at their institutions. We reviewed tumors that include sarcoma with EWSR1-non-ETS fusion, CIC-rearranged sarcoma, BCOR-rearranged sarcoma, Ewing sarcoma, alveolar rhabdomyosarcoma, desmoplastic small round cell tumor, high-grade/round cell myxoid liposarcoma, poorly differentiated synovial sarcoma, small-cell type osteosarcoma, mesenchymal chondrosarcoma, and extraskeletal myxoid chondrosarcoma. Immunohistochemistry plays a crucial role in interpreting a specific diagnosis or narrowing the differential diagnosis of SRCTs. Molecular genetic investigations are essential, particularly in cases exhibiting atypical or overlapping histologic and immunohistological features. - Source: PubMed
Publication date: 2026/04/03
Nagy AnitaSergi Consolato M - The fermentation temperature of sauce-flavored high-temperature Daqu can reach 65 °C, where microbial diversity and abundance are closely associated with liquor yield and quality. This study aimed to isolate thermotolerant yeast strains from sauce-flavored high-temperature Daqu and investigate their tolerance mechanisms and safety profiles. Using sauce-flavored Daqu as material, culturable methods were applied for yeast isolation and screening, followed by whole-genome sequencing analysis. The biological characteristics were examined, and gain an in-depth understanding of their high-temperature resistance mechanisms and characteristics. A thermotolerant yeast strain L253 was isolated and identified as Lodderomyces elongisporus, exhibiting maximum temperature tolerance at 55 °C with optimal growth at 45 °C, pH tolerance of 3-8, alcohol tolerance up to 6.8% (v/v), and sugar tolerance reaching 80% (w/v). Safety assessments demonstrated weak nitrate reductase activity, non-hemolytic properties, and negative indole test, confirming its safety. The genome (GenBank: PRJNA1185419) measured 16,118,111 bp with 37.3% G + C content, containing 5,102, 4,170, 3,390 and 5,380 annotated genes in eggNOG, GO, KEGG and NR databases respectively. Thermotolerance-related genes included HSFF, HSP70 and its interacting proteins (HSPBP1, HSPA5/BiP), and HSP90, while osmotolerance involved gpd and gpp genes. In this study, the phenotype and genotype of strain L253 were analyzed to increase the understanding of microbial functions in the high-temperature Daqu environment, and reveal the potential value of this strain in industrial fermentation. - Source: PubMed
Publication date: 2026/02/03
Rao XuexueLi LinlingLi MeiyanShi JuyangWang XiaodanCao WentaoLuo Xiaoye - While the influence of both genetic and environmental factors on the development of psychiatric symptoms is well-recognized, the precise nature of their interaction throughout development remains a subject of ongoing debate. This study investigated the association between the expression of 78 candidate genes, previously associated with psychiatric phenotypes, in peripheral blood and both adversity and psychopathology in a sample of 298 young individuals assessed at two time points from the Brazilian High Risk Cohort Study for Mental Conditions (BHRCS). - Source: PubMed
Publication date: 2025/02/13
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