SPOP Antibody
- Known as:
- SPOP Antibody
- Catalog number:
- XW-7900
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- SPOP Antibody
Related genes to: SPOP Antibody
- Gene:
- SPOP NIH gene
- Name:
- speckle type BTB/POZ protein
- Previous symbol:
- -
- Synonyms:
- TEF2, BTBD32
- Chromosome:
- 17q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-07
- Date modifiied:
- 2016-02-10
Related products to: SPOP Antibody
Related articles to: SPOP Antibody
- Breast cancer remains one of the leading causes of cancer-related mortality among women. The molecular heterogeneity of breast cancer, reflected in its numerous subtypes with variable responses to conventional and targeted therapies, necessitates the development of novel therapeutic strategies. Speckle-type POZ protein (SPOP), a substrate adaptor for Cul3-dependent ubiquitin ligase complexes, is frequently downregulated in breast cancer, yet the mechanisms linking SPOP loss to breast oncogenesis are poorly understood. This study aimed to elucidate the role of SPOP deficiency in breast cancer progression and identify potential therapeutic vulnerabilities associated with this molecular context. - Source: PubMed
Augustine PatriciaChavarria JazminBurleson Marieke - The immune system's evolution is crucial for its role in fighting pathogens and involvement in autoimmune and neurodegenerative diseases. The GFI1 gene family plays a role in the regulation of the function of immune cells, including neutrophils and CD4 + T cells. GFI1 consists of two members, GFI1A and GFI1B. GFI1A is vital for myeloid and lymphoid differentiation, while GFI1B is crucial for generating red blood cells and platelets. Both genes share a repressor SNAG domain and C2H2 zinc finger domains. However, the full relationship between their structure and function remains unclear. We aimed to decipher the relationship between structural evolution and novel functionalization in the GFI1 gene family. We employed a comprehensive phylogenetic approach that integrated tree construction, ancestral state reconstruction, positive selection analysis, motif mining, and non-homology-based functional prediction to trace GFI1 family evolutionary history over 700 million years. Our analysis revealed that the GFI1 gene family originated from a single ancestral gene in early metazoans and underwent multiple lineage-specific duplication events in invertebrates, jawless vertebrates, and jawed vertebrates, indicating adaptive diversification across evolutionary lineages, albeit without evidence of significant positive selection. We identified new motifs in the less-characterized middle regions, such as the SPOP-binding motif in GFI1A, potentially regulating cytokine production in CD4 + T cells, and the FEDFW motif, possibly involved in neutrophil recruitment. These motifs are unique to GFI1A in higher vertebrates. In GFI1B, we discovered a unique EPLRP motif, a separase cleavage site linked to sister chromatid separation. Our results indicate that GFI1 has evolved new functions to adapt to the complexity of the vertebrate immune system. - Source: PubMed
Publication date: 2026/04/28
Religa PiotrKubick NorwinŁazarczyk MarzenaTsegaye BiniyamŁawiński MichałPaszkiewicz JustynaAtanasov AtanasHorbańczuk JarosławSacharczuk MariuszMickael Michel - Tumor genomic profiling using liquid biopsies offers a minimally invasive alternative to tissue biopsy-based approach, with advantages in accessibility, tumor heterogeneity representation, and repeatability. While established in metastatic prostate cancer, its feasibility in localized disease remains unclear due to low ctDNA levels. - Source: PubMed
Publication date: 2026/04/10
Bettoni FabianaCoser Elisângela MonteiroDos Santos Ernande XavierCanteli Amanda Rafaela AlvesMorandi Filho RomualdoLira VandeclécioLoureiro LiviaDellamano MarciaTorrieri RaulAlves Maria José FerreiraCardili LeonardoMuniz David Queiroz BorgesIlário Éder NisiChammas RogerNahas William CarlosBastos Diogo AssedCamargo Anamaria Aranha - Prostate cancer (PCa) is a highly prevalent malignant tumor in males. Lysine β-hydroxybutyrylation (Kbhb), an emerging post-translational modification, plays a critical role in tumorigenic processes. However, its functional mechanism in PCa remains elusive. This study aims to identify Kbhb-related prognostic genes in PCa and provide novel insights for its diagnosis, prognosis and treatment. - Source: PubMed
Publication date: 2026/04/10
Meng YonghuiHe JinjunYan AnChe BangweiTang KaifaZhang Tao - B7-H3 (CD276) represents a promising therapeutic target tested in high-risk localized and treatment-refractory metastatic prostate cancer (PC). To guide therapeutic development and treatment strategies, we examined prostate tumors and evaluated expression, molecular features, and overall survival (OS), accounting for tissue site, hormone-sensitivity status, and race. - Source: PubMed
Publication date: 2026/04/21
Makovec AllisonGustafson Ava PGandhi NishantRampalli SwatiArafa Ali TElliott AndrewSmith NormFelices MartinKennedy Philippa RShenderov EugenePatnaik AkashNarayan VivekHeath Elisabeth IZorko Nicholas AShi XiaoleiAntonarakis Emmanuel SMcKay Rana RHwang Justin