RFC3 Antibody
- Known as:
- RFC3 Antibody
- Catalog number:
- XW-7875
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- RFC3 Antibody
Related genes to: RFC3 Antibody
- Gene:
- RFC3 NIH gene
- Name:
- replication factor C subunit 3
- Previous symbol:
- -
- Synonyms:
- RFC38, MGC5276
- Chromosome:
- 13q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-10-14
- Date modifiied:
- 2015-11-09
- Gene:
- RFC4 NIH gene
- Name:
- replication factor C subunit 4
- Previous symbol:
- -
- Synonyms:
- A1, RFC37
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-10-14
- Date modifiied:
- 2016-10-05
- Gene:
- RFC5 NIH gene
- Name:
- replication factor C subunit 5
- Previous symbol:
- -
- Synonyms:
- RFC36
- Chromosome:
- 12q24.23
- Locus Type:
- gene with protein product
- Date approved:
- 1994-10-14
- Date modifiied:
- 2016-10-05
Related products to: RFC3 Antibody
Related articles to: RFC3 Antibody
- Olaparib exhibits antitumor effects in castration-resistant prostate cancer patients with germline mutations in DNA repair genes. We previously reported that simvastatin reduced the expression of DNA repair genes in PC-3 cells. The efficacy of combination therapy using olaparib and simvastatin as "BRCAness" in castration-resistant and taxane-resistant prostate cancers was evaluated in this study. - Source: PubMed
Publication date: 2025/03/21
Sekine YoshitakaOka DaisukeOhtsu AkiraNakayama HiroshiMiyao TakeshiMiyazawa YoshiyukiArai SeijiKoike HidekazuMatsui HiroshiShibata YasuhiroSuzuki Kazuhiro - Colorectal cancer (CRC) ranks among the most prevalent cancers globally, with its incidence closely tied to DNA damage. The Replication Factor C (RFC) complexes comprises five protein subunits: RFC1, RFC2, RFC3, RFC4, and RFC5. These RFC complexes play crucial roles in DNA replication, repair pathways, activities post DNA damage, and ATP-dependent processes during DNA synthesis. However, the impact of RFC complexes proteins on CRC prognosis remains unclear. To explore this, we employed a computational analysis approach, utilizing platforms such as the DepMap portal, GEPIA, DAVID Bioinformatics for KEGG pathway analysis, Human Protein Atlas (HPA), STRING, and TIMER. Our results indicate that the mRNA levels of RFC1 and RFC5 were the least expressed among CRC cell lines compared to other RFC complex subunits. Notably, low RFC1 and RFC5 expression was correlated with poor prognosis in terms of CRC patients' overall survival (OS). Immunohistochemical results from the Human Protein Atlas demonstrated medium staining for RFC1, RFC2, and RFC5 in CRC tissues. Furthermore, the low expression of RFC1 and RFC5 showed a significant correlation with high expression levels of miR-26a-5p and miR-636, impacting cell proliferation through mismatch repair, DNA replication, and the nucleotide excision repair pathway. Although the precise functions of RFC1 in cancer are still unknown, our findings suggest that the small-molecule single target, CHEMBL430483, and multiple target molecules could be potential treatments for CRC. In conclusion, the elevated expression of miR-26a-5p and miR-636 targeting RFC1 and RFC5 expression holds promise as a potential biomarker for early-stage CRC detection. These insights provide novel directions and strategies for CRC therapies. - Source: PubMed
Publication date: 2024/03/19
Misbah MdKumar ManojNajmi Abul KalamAkhtar Mymoona - To reveal the expression and prognostic value of replication factor C family genes (RFCs) in patients with sarcoma. - Source: PubMed
Publication date: 2022/04/29
Wu GenZhou JianZhu XiTang XianzheLiu JieZhou QiongChen ZiyuanLiu TangWang WanchunXiao XungangWu Tong - Lynch-like syndrome (LLS) represents around 50% of the patients fulfilling the Amsterdam Criteria II/revised Bethesda Guidelines, characterized by a strong family history of Lynch Syndrome (LS) associated cancer, where a causative variant was not identified during genetic testing for LS. - Source: PubMed
Publication date: 2019/07/12
Xavier AlexandreOlsen Maren FridtjofsenLavik Liss AJohansen JosteinSingh Ashish KumarSjursen WencheScott Rodney JTalseth-Palmer Bente A - Replication factor C (RFC) family is a complex comprised of the RFC1, RFC2, RFC3, RFC4, and RFC5 subunits, which acts as a primer recognition factor for DNA polymerase. It is reported that RFC, biologically active in various malignant tumors, may play an important role in the proliferation, progression, invasion, and metastasis of cancer cells. It could act as an oncogene or tumor suppressor gene based on the cellular and histological characteristics of the tumor. In this review, we summarized the updated researches on the structure, physiological function, and expression pattern of RFC in a variety of tumors, the underlying mechanisms on carcinogenesis, and the potentials of RFC family members in the diagnosis and prognosis prediction. - Source: PubMed
Publication date: 2018/08/01
Li YanlingGan SijieRen LinYuan LongLiu JunlanWang WeiWang XiaoyuZhang YiJiang JunZhang FanQi Xiaowei