PTPN13 Antibody
- Known as:
- PTPN13 Antibody
- Catalog number:
- XW-7835
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- PTPN13 Antibody
Related genes to: PTPN13 Antibody
- Gene:
- PRY NIH gene
- Name:
- PTPN13 like Y-linked
- Previous symbol:
- -
- Synonyms:
- PTPN13LY, PRY1
- Chromosome:
- Yq11.223
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-21
- Date modifiied:
- 2018-04-30
- Gene:
- PRY2 NIH gene
- Name:
- PTPN13 like Y-linked 2
- Previous symbol:
- -
- Synonyms:
- PTPN13LY2
- Chromosome:
- Yq11.223
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-25
- Date modifiied:
- 2018-04-30
- Gene:
- PTPN13 NIH gene
- Name:
- protein tyrosine phosphatase non-receptor type 13
- Previous symbol:
- -
- Synonyms:
- PTP1E, PTP-BAS, PTPL1, PTP-BL
- Chromosome:
- 4q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-02-17
- Date modifiied:
- 2019-02-14
Related products to: PTPN13 Antibody
Related articles to: PTPN13 Antibody
- In this study, we aimed at analysing the expression of the PRY (PTPN-13 like on the Y chromosome) gene, located on the Y chromosome, in order to define the function of this gene. Active copies of the PRY gene (PRY1 and PRY2) are located in the AZFb region. PCR amplification of PRY cDNA indicated that the PRY gene is expressed in testicular tissue and ejaculated sperm, but not in Percoll-treated sperm. Furthermore, immunocytochemistry on testicular tissue showed the expression of the PRY gene in a small number of spermatozoa and spermatids. In the ejaculate of the male partner of 18 infertile couples, the PRY protein was found in 1.5-51.2% of spermatozoa and in most of the sperm precursor cells. The percentage of spermatozoa showing DNA fragmentation was also determined in 13 of these samples, by using the TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labelling (TUNEL) reaction. These data correlated with the percentage of PRY-positive cells. When double labelling for PRY and DNA fragmentation was performed to assess whether PRY-positive cells also show DNA fragmentation, we saw that 27-48% of the PRY-positive spermatozoa were also positive for the TUNEL reaction. The overall data of RNA analysis, immunocytochemistry and the TUNEL reaction indicate that the role of the PRY gene in spermatogenesis can be questioned, but suggest its involvement in apoptosis of spermatids and spermatozoa. - Source: PubMed
Stouffs KatrienLissens WillyVerheyen GretaVan Landuyt LisbetGoossens AnnietaTournaye HermanVan Steirteghem AndréLiebaers Inge - PRY (PTP-BL related on the Y chromosome) has been proposed as a candidate spermatogenesis gene. We report the characterization of the genomic structure, the number of copies on the Y chromosome and the expression of the gene. By comparison of the cDNA sequence with the genomic sequence, five exons were identified. Analysis of GenBank-derived clones on the Y chromosome revealed the presence of two full-length copies in azoospermia factor region b (AZFb) (PRY1 and PRY2) and two shorter versions of the PRY gene containing exons 3, 4 and 5 in AZFc (PRY3 and PRY4). A clone containing sequences homologous to exons 3, 4 and 5 is located in area 5L (between AZFa and AZFb), a clone containing a sequence homologous to exon 5 is located in area 5M (in AZFb) and a clone containing a fragment homologous to exon 3 is located in 6F. A repeat structure of exons 1 and 2 is present on the short arm of the Y chromosome as well as on the long arm. PRY1 and PRY2, two gene copies that are located in AZFb, a region often deleted in patients with severe male infertility, were shown to be expressed in the testis. PRY may therefore play an important role in spermatogenesis. - Source: PubMed
Stouffs KLissens WVan Landuyt LTournaye HVan Steirteghem ALiebaers I