PTPRN Antibody
- Known as:
- PTPRN Antibody
- Catalog number:
- XW-7822
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- PTPRN Antibody
Related genes to: PTPRN Antibody
- Gene:
- PTPRN NIH gene
- Name:
- protein tyrosine phosphatase receptor type N
- Previous symbol:
- -
- Synonyms:
- IA-2, ICA512
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1995-02-17
- Date modifiied:
- 2019-02-14
Related products to: PTPRN Antibody
Related articles to: PTPRN Antibody
- Among primary intracranial neoplasms in adults, glioblastoma multiforme stands out for both its prevalence and its exceptionally invasive character. Uric acid-related genes (UARGs) may enhance tumor cell invasiveness and drug resistance by promoting oxidative stress responses. This study aimed to elucidate uric acid-driven mechanisms in glioblastoma, focusing on risk stratification and therapeutic vulnerability. - Source: PubMed
Publication date: 2026/04/20
Sun KaiLi ChaoWang JiangtingXu Ruxiang - Autoantibodies targeting islet antigen 2 (IA2) are critical diagnostic and prognostic markers for type 1 diabetes (T1D). Standard clinical assays do not differentiate between IgG and IgM isotypes, yet these antibodies have distinct roles in the T1D autoimmunity. We therefore adapted electrochemiluminescence (ECL) assays to separately detect IgG and IgM antibodies against the IA2 intracellular domain (AA601-979). Assay specificity was confirmed by indirect immunofluorescence, which showed autoantibody binding to IA2-overexpressing cells. Plasma samples were analyzed from two independent cohorts: organ donors of the Human Pancreas Analysis Program (HPAP, = 69) and children from a Janssen-Breakthrough T1D-funded study ( = 65). Diabetics had significantly higher levels of IA2 IgG ( < 0.001) but not IgM ( > 0.05) compared with controls. Notably, IgM and IgG IA2 antibody levels were not correlated. However, IgM modulates IgG detection: IgM depletion increased detected IgG levels to IA2 in some donors, and sera from donors with high IA2-specific IgM levels reduced monoclonal IgG anti-IA2 antibody binding to IA2. Purified IgM from healthy individuals also suppressed monoclonal IgG binding. These findings support distinct, non-redundant roles for IA2-specific IgG and IgM in T1D serology. Isotype-specific autoantibody analysis may improve risk stratification and monitoring of T1D individuals receiving immunomodulatory therapies. - Source: PubMed
Publication date: 2026/03/26
Mao XumingKonigsberg JakeNoorchashm NadiaMeng WenzhaoKnox James JGolden Gregory JHamilton Jacob TMaxwell Tara KLiu ChengyangBetts Michael RWilli Steven MNaji AliHanley PatrickLuning Prak Eline T - - Source: PubMed
Publication date: 2026/04/12
Dong XueshanYu LuhangLi Yifan - Chemotherapy resistance in colorectal cancer (CRC) is often mediated by enhanced DNA damage repair (DDR). Transmembrane protein TMEM59L is implicated in cancer progression, but its role in CRC chemoresistance is unclear. We investigated whether TMEM59L regulates 5-fluorouracil (5-FU) sensitivity through PTPRN-mediated DDR. - Source: PubMed
Jin WenzhiMa QiangMa ZenghuiHou JianhuaWang FenmingKang HuiqingWang ChenWang XiaoliangLiu Feng - The discovery of novel marine natural products and their sustainable application continue to be vital focuses in marine biological research. The aim of this study is to investigate the inhibitory effect of the compound 5Z-7-Oxozeaenol isolated from the fungus sp. MDCW-1060 on the proliferation of MDA-MB-231 cells and its molecular mechanism. A series of functional assays, including 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), flow cytometry, Transwell migration, and colony formation, were employed to evaluate the effects of 5Z-7-Oxozeaenol on cellular viability, apoptosis, migration, and clonogenicity. The RNA sequencing (RNA-seq) coupled with bioinformatic analysis was conducted to identify affected differentiated gene expression and signaling pathways. The molecular docking was performed to predict potential protein targets, and Western blot was used to validate expression and phosphorylation levels of key signaling molecules. The results demonstrated that 5Z-7-Oxozeaenol significantly suppressed proliferation and migration while promoting apoptosis in MDA-MB-231 cells. The transcriptomic analysis indicated enrichment in pathways related to cancer, cytokine-cytokine receptor interaction, MAPK and PI3K-Akt signaling, and cell adhesion molecules. The molecular docking suggested a high binding affinity between 5Z-7-Oxozeaenol and PTPRN. While Western blot analysis confirmed the downregulation of phosphorylated FAK, PI3K, Akt, and MAPK, along with reduced cyclin D1 expression. Additionally, 5Z-7-Oxozeaenol upregulated the pro-apoptotic proteins p53 and cleaved caspase-3. In conclusion, 5Z-7-Oxozeaenol exerts potent antitumor effects on MDA-MB-231 cells through multi-pathway inhibition and induction of apoptosis, highlighting its potential as a marine-derived therapeutic candidate for breast cancer treatment. - Source: PubMed
Publication date: 2025/10/23
Zhang HongWang JianjianXu ChangLiu KaiXie JufangHe ZhouchengLiu YonghongWang CongQu Xinjian