PTPRC Antibody
- Known as:
- PTPRC Antibody
- Catalog number:
- XW-7814
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- PTPRC Antibody
Related genes to: PTPRC Antibody
- Gene:
- PTPRC NIH gene
- Name:
- protein tyrosine phosphatase receptor type C
- Previous symbol:
- CD45
- Synonyms:
- LCA, T200, GP180
- Chromosome:
- 1q31.3-q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: PTPRC Antibody
Related articles to: PTPRC Antibody
- Oral squamous cell carcinoma (OSCC) arises in the context of diverse etiological exposures, such as tobacco, alcohol, areca nut use and viral infections. This etiological heterogeneity drives distinct molecular alterations, contributing to tumor complexity and significant challenges in identifying robust, clinically applicable biomarkers. - Source: PubMed
Publication date: 2026/08/11
Kamei DuanreiliuKaur SimranPriya AnjaliBansal AkshayYadav AartiRay AshwiniAgrawal Yamini - Human adenoviruses (HAdVs) cause a broad spectrum of diseases, ranging from mild respiratory and gastrointestinal infections to severe, sometimes even fatal illness in immunocompromised individuals. Species D adenoviruses represent the largest group, possibly driven by strong evolutionary pressure, particularly within the highly variable early transcription unit 3 (E3), which encodes immunomodulatory proteins. Among these, E3/49K is unique to species D and utilizes a particularly intriguing immunomodulatory strategy. It is a heavily glycosylated transmembrane protein that undergoes proteolytic shedding to release the soluble ectodomain (sec49K), the only known secreted HAdV protein. Both the membrane-anchored and soluble forms target the leukocyte-specific receptor-like protein tyrosine phosphatase CD45, a key regulator of immune cell activation. E3/49K binds CD45 with high affinity via two domains, inducing dimerization and inhibiting its phosphatase activity, thereby suppressing activation of T, B, and NK cells. The species specificity and potent immunomodulatory function of E3/49K underscore its role in adenoviral adaptation and highlight its potential for therapeutic immunosuppression and cancer therapy. - Source: PubMed
Publication date: 2026/07/22
Windheim MarkAichane-Simon Khadija - Retinoblastoma (RB) lacks effective targeted therapies. Super-enhancers (SEs) are crucial for tumorigenesis, yet their role in RB was unclear. - Source: PubMed
Publication date: 2026/08/03
Guo CaiyaoDai WeiLi JingxuanZhou XuanYang JianqiongXie FenfenLiang WanZhou JingfengHou WenLan JinxiaLiu HaiLiu Shenglan - India's indigenous pig genetic resources are central to sustainable meat production and rural livelihoods, yet their genomic potential remains underexplored. The Ghurrah pig, a native breed from northern India, is among the most genetically distinct and adaptively resilient populations, shaped by ancestral admixture from Asian, European, and Indian wild boar lineages. This study elucidates the genetic uniqueness, population structure, and adaptive introgression of the Ghurrah pig by jointly analysing 35,777 high-quality SNPs across 270 global pig genotypes. Higher observed heterozygosity (Ho = 0.287) and lower inbreeding coefficient (F = 0.206) in Ghurrah indicated substantial genetic variability and minimal inbreeding, while its effective population size (Ne = 26 at 13 generations ago) revealed demographic constraint. Linkage disequilibrium (r² = 0.325) and haplotype block structure (average block size = 415.56 kb) reflected reduced recombination and hybrid ancestry. Admixture analysis at K = 5 positioned Ghurrah intermediate between Asian and European clusters, with 39.07% Asian ancestry and significant European introgression. Local ancestry inference identified adaptive admixtures from Asian ancestry on Sus scrofa chromosome (SSC) 10, SSC12, and SSC15 associated with thermotolerance, immune regulation, and stress resilience, while European ancestry on SSC11 enriched pathways for muscle growth and carcass traits. Functionally, genes such as PTPRC, CTSL, and HSPA14 contributed to environmental adaptability, whereas ATP11A influenced lean meat yield. A 1000 SNP ancestry informative marker (AIM) panel revealed 97.25% unique ancestry for Ghurrah, underscoring its genetic distinctiveness. These findings establish Ghurrah as a genomic bridge between Asian and European domestication centres, embodying hybrid vigour and adaptive potential. The study emphasizes the need for genomic-assisted conservation breeding to safeguard Ghurrah's genetic integrity and promote its sustainable use in tropical production systems. - Source: PubMed
Publication date: 2026/07/24
Goli Rangasai ChandraChishi Kiyevi GSruthi Oguru SaiGunturu TanujSukhija NidhiMetta MuralidharKanaka K KNandineni Madhusudan R - - Source: PubMed
Publication date: 2026/07/22
Qin JunkaiTang NingHuang DongjunZhang ZhifuLu GuopingChen YuanboHuang Xijian