TAF7 Antibody
- Known as:
- TAF7 Antibody
- Catalog number:
- XW-7810
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- TAF7 Antibody
Related genes to: TAF7 Antibody
- Gene:
- TAF7 NIH gene
- Name:
- TATA-box binding protein associated factor 7
- Previous symbol:
- TAF2F
- Synonyms:
- TAFII55
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-07
- Date modifiied:
- 2016-10-05
Related products to: TAF7 Antibody
Related articles to: TAF7 Antibody
- TAF7, a core subunit of the general transcription factor TFIID, regulates transcription and additionally functions as an RNA chaperone that directs nascent nuclear RNAs to cytoplasmic polysomes, thereby influencing protein synthesis. Here, we identify a set of novel cytoplasmic interactors and a previously unappreciated cytoplasmic role for TAF7 in oncogenesis. BioID-mediated proximity labeling identified STAT3 and the CCT and WASH complexes as prominent cytoplasmic interactors of TAF7. These interactions were validated by co-immunoprecipitation and proximity ligation assays. We further showed that cytoplasmic TAF7 levels increased during oncogenesis in proportion to cancer cell pathogenicity. Notably, TAF7 engagement with STAT3, CCT and WASH complexes is markedly enhanced during cellular transformation, consistent with their functions in cancer progression. Together, these findings reveal a cytoplasmic TAF7 interactome and implicate elevated cytoplasmic TAF7 as associated with oncogenesis. - Source: PubMed
Publication date: 2026/07/08
Cheng DanMcManus ElizabethYoung Ryan MOellerich ThomasHaupl BjornBilladeau Daniel DTan HuaElnitski LauraSinger Dinah S - Non-functioning pituitary adenomas (NFPAs) present a complex clinical challenge due to their indolent and invasive growth patterns, and critical anatomical location. Post-surgical tumor progression is frequent in patients with NFPAs, which often necessitates additional therapeutic interventions. The molecular mechanisms underlying post-surgical progression remain poorly understood and there are currently no reliable methods to stratify patients according to risk of tumor progression. The aim of this study was to comprehensively characterize the molecular alterations, together with an integrated understanding of their interactions, that could potentially uncover the biological processes driving post-surgical tumor progression of NFPAs. - Source: PubMed
Publication date: 2026/06/23
Suman MedhaHallén TobiasGarner TerenceThorsell AnnikaStevens AdamKöster LinusCarén HelenaRagnarsson OskarSkoglund ThomasJohannsson Gudmundur - Achieving an optimal balance among key optical performance parameters (i.e., bandgap, second-harmonic generation (SHG), and birefringence) is critically important for addressing application constraints and advancing the development of nonlinear optical (NLO) materials. We report herein the first examples of deep-ultraviolet (deep-UV) transparent mixed d-metal oxyfluorides A(NbOF)(TaF) (ANTOF: A = K, Rb, Cs, NH), synthesized through a synergistic dual-site strategy. Our synthetic strategy enables the targeted incorporation of highly distorted d-metal octahedra into metal fluorides, creating two distinct d-metal polyhedra with complementary microstructural features that can reconcile trade-offs in key optical properties. By introducing 4d-Nb-based [NbOF] oxyfluoride octahedra into the centrosymmetric parent 5d-Ta-based fluorides ATaF, the resultant ANTOFs not only crystallize with noncentrosymmetric polar structures but, more importantly, demonstrate exceptional performance, including record-high phase-matchable SHG responses for deep-UV transparent d-metal oxyfluorides (3.3-3.8 × KHPO @ 1064 nm (visible region) and 0.33-0.38 × β-BaBO @ 532 nm (UV region)), wide bandgaps (> 6.36 eV), and suitable birefringence (Δn = 0.093-0.105 @ 546 nm). Theoretical calculations and crystal structure analyses reveal that the superior linear and nonlinear optical properties of the ANTOFs originate from the dual-site synergy between the polarizable [NbOF] octahedra and the [TaF] pentagonal bipyramids, in which ligand-to-metal charge transfer transitions are suppressed. - Source: PubMed
Publication date: 2025/09/16
Zhang XiaotianJiang XingxingGao HuiDuanmu KainingWu ChaoLin ZheshuaiHuang ZhipengHumphrey Mark GZhang Chi - The whiteleg shrimp (Penaeus vannamei) is one of the most economically important aquaculture species worldwide. Transcription initiation factor TFIID subunit 7 (TAF7), a core component of the TFIID complex, is known to regulate transcription through interactions with other transcription factors. However, its role in crustacean immunity remains largely unexplored. In this study, we cloned and functionally characterized a TAF7 homolog from P. vannamei, designated as PvTAF7. The gene comprises an open reading frame (ORF) of 1110 bp, encoding a 369-amino-acid protein containing a conserved TAFⅡ55 domain. Phylogenetic analysis clustered PvTAF7 within the Decapoda clade, indicating strong evolutionary conservation among crustaceans. Tissue distribution analysis showed that PvTAF7 is highly expressed in the hepatopancreas and hemocytes, key immune tissues in shrimp. PvTAF7 expression was significantly upregulated in response to Vibrio parahaemolyticus (including the AHPND strain) in both hemocytes and hepatopancreas. RNA interference-mediated knockdown of PvTAF7 led to reduced expression of immune-related genes, including lysozyme, crustins, hemocyanins, and the transcription factor PvYY1, and resulted in increased mortality following Vibrio infection. Moreover, GST pull-down assays and structural modeling demonstrated that PvTAF7 interacts with PvYY1 via its TAFⅡ55 domain and the zinc finger domain of PvYY1, forming a functional protein complex. Collectively, these findings reveal that PvTAF7 plays a critical role in the antibacterial immune response of P. vannamei, likely by regulating immune gene expression through its interaction with PvYY1. - Source: PubMed
Publication date: 2025/07/30
Yang PeikuiWang ShuqinChen TongyingZhao QiongjunYe XuelianZeng BoxiZou XianghuiZheng YuzhongWang Ruixuan - Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with a poor prognosis. Identifying reliable prognostic biomarkers and therapeutic targets is crucial for improving patient outcomes. This study aimed to systematically identify proliferation-essential genes (PEGs) associated with HNSCC prognosis using CRISPR-Cas9 screening data. - Source: PubMed
Publication date: 2025/04/22
Pang Ke-LingLi PianYao Xiang-RongXiao Wen-TaoRen XingHe Jun-Yan