ITGB7 Antibody
- Known as:
- ITGB7 Antibody
- Catalog number:
- XW-7801
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- ITGB7 Antibody
Related genes to: ITGB7 Antibody
- Gene:
- ITGB7 NIH gene
- Name:
- integrin subunit beta 7
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-10-07
- Date modifiied:
- 2016-10-11
Related products to: ITGB7 Antibody
Related articles to: ITGB7 Antibody
- Short-chain fatty acids (SCFAs) are produced by the gut microbiota as secondary metabolites during fermentation process of dietary fibers. Although SCFAs are beneficial for immuno-related diseases because they regulate the gene expression and functions of myeloid cells, the effects of SCFAs on the development of DCs remain unclear. - Source: PubMed
Publication date: 2026/06/18
Zhao WeitingNagata KazukiAkiyama RisakoYamazaki YukiKouda HirotoMiura RyosukeIshii KentaTokita RyuseiIto NaotoYamasaki NorimasaKaminuma OsamuNishiyama Chiharu - Breast cancer (BRCA) remains one of the most frequently diagnosed malignancies and a leading cause of cancer-related mortality among women worldwide. Its molecular heterogeneity and limited therapeutic options for aggressive subtypes highlight the need for novel treatment strategies. Drug repositioning offers a promising approach by identifying new therapeutic uses for existing drugs with established safety profiles. - Source: PubMed
Publication date: 2026/05/19
Adikusuma WirawanIrham Lalu MuhammadSatria Rahmat DaniNurlaila IkaDewi Dyah LaksmiFirdayani FirdayaniSyafarina Inna - Plasma cells (PCs) are terminally differentiated B cells that are long-lived and have high rates of protein secretion. Because of these features, ex vivo generated PCs are being developed as therapeutics for long-term protein delivery. Here, we used proteomics and flow cytometry-based approaches to comprehensively interrogate the surface proteome of activated B cell versus PC populations. Next, we analyzed adhesion proteins that might facilitate engraftment of ex vivo generated PCs at candidate immune sites. We identified key adhesion proteins including integrin alpha 4 (ITGA4) and ITGB1 that were highly expressed on PCs and activated B cells. At steady state, ITGB1 preferentially paired with ITGA4 preventing the pairing of ITGA4 and ITGB7. This phenotype was unique to human versus mouse PCs, indicating a species-specific pattern of integrin expression. Despite high expression on human PCs, ITGB1 was dispensable for human PC BM engraftment but partially required for murine PC engraftment. To investigate the role of integrins in directing localization of murine PCs to specific organs, we generated PCs that expressed high levels of ITGA4, ITGB1, and/or ITGB7. We observed localization of PCs expressing high levels of these integrins to lymphoid and nonlymphoid organs in the peritoneum. Taken together, our findings identify surface proteins on human PCs and showcase PC targeting to peritoneal tissues allowing for potential delivery of therapeutic drugs within the abdominal cavity. - Source: PubMed
Trivedi NikitaCamp Nathan DCheng Rene Yu-HongRamonett AaronRawlings David JJames Richard G - BACKGROUND: The role of nicotinamide in improving cardiac function suggests its therapeutic benefit for acute myocardial infarction (AMI). This study aims to identify key genes associated with nicotinamide metabolism in AMI, offering novel insights into its therapeutic management. METHODS: The GSE60993 and GSE61144 datasets were retrieved from the database. Mendelian randomization (MR) analysis, Cytoscape-plugin cytoHubba algorithms, and expression validation were used to identify key genes linked to nicotinamide metabolism. Subcellular localization, gene set enrichment analysis (GSEA), immune infiltration analysis, drug prediction, and molecular docking were then performed. Finally, the expression of key genes was validated experimentally in clinical samples. RESULTS: Three key genes (FLT3LG, ITGB7, and PARP1) were found to be causally associated with AMI, ranking in the top three of the three Cytoscape-plugin cytoHubba algorithms. FLT3LG and ITGB7 were identified as risk factors (odds ratio [OR] > 1, P-value < 0.05), while PARP1 was a protective factor (OR < 1, P-value < 0.05). Expression analysis in GSE60993 and GSE61144 confirmed similar trends for these genes. FLT3LG and ITGB7 were predominantly located in the cytoplasm, whereas PARP1 was mainly in the nucleus. GSEA results indicated involvement of these genes in pathways such as the ribosome, oxidative phosphorylation, and spliceosome. Immune infiltration analysis showed that neutrophil scores were higher in AMI and negatively correlated with ITGB7 (cor = -0.84), PARP1 (cor = -0.75), and FLT3LG (cor = -0.86). Drug prediction and molecular docking revealed strong correlations between the key genes and Tetradioxin, with excellent binding ability. Expression trends of the three genes in clinical samples aligned with bioinformatics findings. CONCLUSIONS: This study identified three genes associated with nicotinamide metabolism whose altered expression or function may have played a role in the pathological process of AMI. These genes could provide potential reference points for the diagnosis and treatment of AMI. - Source: PubMed
Publication date: 2026/03/29
Qu NanBai FawenLan Jin - Coronary heart disease (CHD) is a leading cause of cardiovascular mortality worldwide, with its pathogenesis being complex and not yet fully understood. The rapid development of genomics, especially in epigenetic research, has provided essential tools for identifying new pathogenic targets. This study is aimed at systematically exploring the molecular mechanisms of CHD using protein quantitative trait locus (pQTL) data and multiomics Mendelian randomization (MR) approaches, with a specific focus on the epigenetic regulation of the key gene ITGB7. - Source: PubMed
Publication date: 2026/01/07
Guo JunchiHuang FangLu PeihanLu Meijuan