SOX15 Antibody
- Known as:
- SOX15 Antibody
- Catalog number:
- XW-7777
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- SOX15 Antibody
Related genes to: SOX15 Antibody
- Gene:
- SOX15 NIH gene
- Name:
- SRY-box 15
- Previous symbol:
- SOX20
- Synonyms:
- SOX27, SOX26
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-15
- Date modifiied:
- 2015-11-23
Related products to: SOX15 Antibody
Related articles to: SOX15 Antibody
- Polycystic ovary syndrome (PCOS), a leading cause of infertility in reproductive-aged women, exhibits complex etiology involving environmental endocrine disruptors (EEDs). Di(2-ethylhexyl) phthalate (DEHP) and bisphenol A (BPA) are implicated in PCOS pathogenesis, though their molecular mechanisms remain incompletely characterized. To address this, network toxicology was employed to systematically investigate DEHP/BPA-induced toxicity and associated mechanisms in PCOS. Through comprehensive queries of public databases-including the U.S. Environmental Protection Agency (EPA) ToxCast, Comparative Toxicogenomics Database (CTD), SwissTargetPrediction, GeneCards, and Online Mendelian Inheritance in Man (OMIM)-we identified 26 and 21 putative targets for DEHP/BPA, respectively, with established links to PCOS. Subsequent protein-protein interaction (PPI) network analysis using STRING (v11.0) and Cytoscape (v3.9) identified six hub proteins: PTGER3, SOX15, TOP2A, CCNB1, BCL2, and CYP19A1. Functional enrichment analysis via ClusterProfiler package (version 4.14.6) revealed these targets are significantly enriched in endocrine disruption pathways and ovarian folliculogenesis processes. Molecular docking simulations further validated high-affinity binding between DEHP/BPA and the hub proteins indicating stable interactions. Our results suggest that DEHP/BPA may contribute to PCOS through potential disruption of endocrine signaling, alterations in ovarian hormone regulation, and interference with follicular development and steroidogenesis. These disturbances are predictive of hormonal imbalances, inflammation, and reduced ovarian function, which represent established features of PCOS pathogenesis. The network toxicology approach provides insights into toxicity pathways and could assist in managing risks associated with endocrine-disrupting substances. - Source: PubMed
Publication date: 2025/11/18
Li YiqiuJiang YuxiaoZhu BozhiZhang YuLiu XunruiGe LiyingHu TaoWang Mingming - The early growth traits including birth weight (BW), weaning weight (WW), pre-weaning average daily gain (ADG) and yearling weight (YW) are crucial productivity indicators that directly influence growth rates of cashmere goats and economic income of herdsmen in the cashmere goat breeding programs. However, the genetic mechanism of these traits in Inner Mongolia Cashmere Goats (IMCGs) has not been elucidated.Copy number variation (CNV), as a prevalent form of genomic structural variation and a significant contributor to the genetic diversity, has emerged as a valuable molecular marker for analysis of complex traits. - Source: PubMed
Publication date: 2025/10/17
Liu YifanXi HaijiaoXu QiZhou BohanLi JinquanSu RuiLv QiZhang YanjunWang RuijunWang Zhiying - Tobacco smoke is a major risk factor for esophageal squamous cell carcinoma (ESCC), yet only a subset of smokers develop this disease, implicating gene-smoking interactions in modulating individual susceptibility. Through integrative transcriptomic analyses of normal and tumor samples from smokers and nonsmokers, we identify four smoke-responsive genes (CXCL14, HORMAD1, WFDC5, and MPZ) as potential contributors to ESCC carcinogenesis. Among these, HORMAD1 is markedly upregulated in ESCC cells upon exposure to cigarette smoke condensate (10 µg/mL), benzo[a]pyrene (3 µM), or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (10 µM), correlating with activation of error-prone nonhomologous end joining (NHEJ) in response to DNA damage. Notably, smokers with higher HORMAD1 expression levels exhibit enhanced NHEJ but impaired homologous recombination (HR), leading to increased genomic instability. Through a two-stage case-control study involving 5151 ESCC cases and 5963 controls, we identify two regulatory variants of HORMAD1, rs11204679 and rs33924488, significantly associated with ESCC risk through a gene-smoking interaction (p = 0.0027). Both variants confer a protective effect among smokers (OR = 0.80, 95% CI: 0.74-0.87, p = 9.58 × 10 ) but not in nonsmokers (OR = 0.98, 95% CI: 0.90-1.06, p = 0.5950). Mechanistically, the rs11204679 G > C and rs33924488 GA > G- variants attenuate HOXA6 and SOX15 binding at a distal enhancer, respectively, suppressing HORMAD1 expression via long-range chromatin interactions. These findings establish HORMAD1 as a critical mediator of tobacco-related DNA repair dysregulation and a potential biomarker for ESCC risk stratification and precision prevention. - Source: PubMed
Publication date: 2025/08/28
Yue XinyingYang ZifeiMa JialingSu QianqianPan MiaoxinSong LinaLi YuepingLiu ShashaWu YutongChang Jiang - Vascular mimicry (VM) is pivotal for promoting tumor cell proliferation and invasion in ovarian (OV) cancer patients. Sex-determining region Y-box 15 (SOX15) suppresses the malignant growth of tumor cells. However, the function of SOX15 in OV cancer remains undefined. Using SKOV-3 and ES2 cell lines, along with xenograft models in nude mice, we investigated the effects of SOX15 on tumor cell growth and VM formation in OV cancer, as well as the underlying mechanisms. - Source: PubMed
Zhao XiaodanWang XinjiaWang ChaoTian HuiyuZhou YangGong Lihong - GATA family transcription factors are somatically variable (SV) in esophageal adenocarcinomas (EAC) and inducible by simulated reflux. Our study examines the mechanisms whereby GATA family members (GATA4, GATA6, and the atypical TRPS-1) influence oncogenesis during the Barrett's esophagus (BE) metaplasia-dysplasia transition preceding EAC. - Source: PubMed
Publication date: 2025/06/07
Abuhussein OmarHosseini-Farahabadi SaraStewart CorinaFlibotte StephaneHeravi-Moussavi AlirezaFarnell DavidSchaeffer DavidDonnellan FergalMcKeon FrankXian WaKelleher DermotDuggan Shane Patrick