FLJ20259 Antibody
- Known as:
- FLJ20259 Antibody
- Catalog number:
- XW-7774
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- FLJ20259 Antibody
Related genes to: FLJ20259 Antibody
- Gene:
- QRICH1 NIH gene
- Name:
- glutamine rich 1
- Previous symbol:
- -
- Synonyms:
- FLJ20259, VERBRAS, AB-DIP
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-19
- Date modifiied:
- 2018-07-31
Related products to: FLJ20259 Antibody
Related articles to: FLJ20259 Antibody
- - Source: PubMed
Publication date: 2026/05/05
Luo Hong-YuHuang Dan-PingYu Qiu-XiaLi Dong-Zhi - Obsessive-compulsive disorder (OCD) affects 2-3% of the population with often disabling obsessions and compulsions. Despite its high heritability, genetic studies of OCD have lagged other psychiatric disorders, particularly in understanding the role of rare genetic variants. - Source: PubMed
Publication date: 2025/12/23
Jung SeulgiHalvorson Matthew WPedersen NancyAvila Marina NatividadNiarchou Maria Devlin BernieRoeder KathrynCrowley James JBuxbaum Joseph DGrice Dorothy E - With global population aging, the incidence of ischemic stroke is rising annually. However, its underlying mechanisms and effective clinical preventive and therapeutic measures remain elusive. This study investigated inflammatory mechanisms and therapeutic targets using a rat cerebral ischemia-reperfusion injury (CIRI) model, focusing on endoplasmic reticulum stress (ERS)-mediated inflammation. - Source: PubMed
Publication date: 2025/12/16
Li JiZhu YongjieHan JingWang ZhenshanXue HongboZhai MeiliLiu Chong - A previously unknown cofactor function stabilizes transcription factor binding across the genome. - Source: PubMed
Publication date: 2025/07/03
Nemčko FilipStark Alexander - Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting of QRICH1 and SEPHS1, as a ZNF-specific coregulator essential for embryonic development in mice and associated with developmental syndromes in humans. We also identified ZFP91 as a representative Zincore client, binding the conserved promoter motif CTTTAAR. Cryo-electron microscopy of a Zincore-ZFP91-DNA complex revealed a SEPHS1 arginine clamp to recognize the DNA-bound zinc finger domains. This mode of binding explains recognition of different ZNFs and stabilizes ZFP91 onto its cognate DNA motif. Thus, our study identified Zincore as a ZNF-specific coregulator essential for development, involving a distinctive mechanism that locks ZNFs onto DNA and regulates transcription. - Source: PubMed
Publication date: 2025/07/03
Bianchi DaniëlleBorza RazvanDe Zan EricaHuelsz-Prince GuizelaGregoricchio SebastianDekker MarleenFish AlexMazouzi AbdelghaniKroese Lona JLinder SimonHernandez-Quiles MiguelVermeulen MichielCelie Patrick H NKrimpenfort PaulSong Ji-YingZwart WilbertWessels LodewykNijman Sebastian M BPerrakis AnastassisBrummelkamp Thijn R