MMP13 Antibody
- Known as:
- MMP13 Antibody
- Catalog number:
- XW-7750
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- MMP13 Antibody
Related genes to: MMP13 Antibody
- Gene:
- MMP13 NIH gene
- Name:
- matrix metallopeptidase 13
- Previous symbol:
- -
- Synonyms:
- CLG3
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-20
- Date modifiied:
- 2016-10-05
Related products to: MMP13 Antibody
Related articles to: MMP13 Antibody
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Publication date: 2026/05/05
Gao YingchaoZhang NingZhang Jun-FeiFei Zhengqi - Osteoarthritis (OA) is a heterogeneous disorder with a rising global prevalence, largely driven by aging and obesity, and it imposes a significant worldwide health burden. Current therapeutic strategies, limited to transient lubrication or pain relief, are unable to halt disease progression due to their failure to repair cartilage. To address this challenge, we developed an integrated theranostic platform using a modified acupuncture needle with helical microgrooves. These grooves are loaded sequentially with three functional hydrogel segments. The degradation of each segment triggers the controlled release of a corresponding therapeutic agent: Batimastat, Etodolac, and Docetaxel. Each hydrogel is engineered to respond specifically to a key OA pathological pathway: matrix degradation (MMP13-responsive), inflammation (ADAMTS5-responsive), and fibrosis (TGF-β-responsive), and is labeled with a distinct fluorescent marker (Cy5, FITC, or Cy5). The core innovation of this system is its capacity for simultaneous diagnosis and treatment. After implantation, the needle can be retrieved, and the degradation status of each hydrogel segment assessed by fluorescence imaging, providing a post-treatment readout of the dominant OA molecular subtype. Collectively, this multifunctional platform, termed helical-groove acupuncture needle (HGN), represents a promising strategy to curtail OA progression by simultaneously promoting cartilage restoration and inhibiting fibrotic changes. - Source: PubMed
Publication date: 2026/05/04
Shi RuixunWang PengSui LongfeiCao ChenxiZhang ZhaofengTan GuihuaWu RuiShi HongfeiLiu AnlongShi Dongquan - Osteoarthritis (OA) brought on by aging damages joints and impairs function. Probiotics are known to be safe to eat, and many of them have positive bioactivity for human health issues. GKD7 mitigates inflammatory cytokine production and has potential for OA treatment. This study investigated whether fermented GKD7 is effective at preventing the advancement of OA. Anterior cruciate ligament transaction-related bone discomfort and OA are lessened by fermented GKD7. Fermented GKD7 prevented the breakdown of aggrecan and type II collagen alpha 1 chain (COL2A1) by lowering pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), as well as the chondrolytic factors metalloproteinase-3 (MMP)-3, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5). This activity prevented cartilage deterioration and bone loss. Our results show that fermented GKD7 improves the prevention of OA formation. - Source: PubMed
Publication date: 2026/03/30
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