CXCL16 Antibody
- Known as:
- CXCL16 Antibody
- Catalog number:
- XW-7727
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- CXCL16 Antibody
Related genes to: CXCL16 Antibody
- Gene:
- CXCL16 NIH gene
- Name:
- C-X-C motif chemokine ligand 16
- Previous symbol:
- -
- Synonyms:
- SR-PSOX, CXCLG16, SRPSOX
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-21
- Date modifiied:
- 2016-10-05
Related products to: CXCL16 Antibody
Related articles to: CXCL16 Antibody
- The bone is the primary site of distant metastasis in patients with nasopharyngeal carcinoma (NPC), and bone metastasis (BM) significantly increases mortality. Deciphering the complex crosstalk between cancer cells and their tumor microenvironment (TME) is crucial for identifying therapeutic targets aimed at eliminating metastasis-initiating cells and preventing the establishment of overt metastases. Regulatory B cells (Bregs), a specialized B-cell subset endowed with potent immunosuppressive functions, play a pivotal regulatory role within the TME. However, their specific contributions, phenotypic characteristics, and underlying molecular mechanisms within the BM niche of NPC remain incompletely characterized and await full elucidation. This study aims to investigate the infiltration dynamics, functional impact, and molecular underpinnings of Bregs in the context of NPC BM. - Source: PubMed
Publication date: 2026/08/27
Yang KaifanZhang JinyeMao XinyuanChen XintongHuang JiandangXie KainanLin XiaoyiZhou XinYu BinZhao LiangLin Yanling - The meninges form the border between the brain and periphery and house a rich network of immune cells. Here we show that gastrointestinal challenges (intracellular or extracellular bacteria and parasites) reshape the nature of CD4 T cells in the dura mater, the outer meningeal layer, changing the dominant polarization states to T helper (T) 1, T17 and T2 cells, respectively, with differing cytokine profiles. This occurs via CXCR6-CXCL16-dependent migration of gut-activated CD4 T cells to the central nervous system, where they establish long-lived memory populations around the dural venous sinuses, within dural lymphoid aggregates and in the brain. Functionally, these orally primed dural CD4 T were capable of rapid, antigen-specific recall responses, proliferating and producing cytokines upon intravenous rechallenge. Our findings reveal a direct link between intestinal and dural immunity, enabling the central nervous system borders to acquire immunological memory of gut microorganisms, a major source of bloodborne pathogens capable of reaching the brain via fenestrated dural vasculature. - Source: PubMed
Publication date: 2026/09/08
Fleming AaronNeish KarenDi Marco-Barros RafaelPosner David ALee Colin Y CStewart AndrewTuong Zewen KelvinBremridge MilesPeñalver AnaCabantous MiaRichoz NathanPortet AnaisHarcourt KatherineGillman EleanorSow Tammie Tao MinHasegawa TetsuoRuano-Gallego DavidFrankel GadWithers DavidClare SimonClatworthy Menna R - In Brazil, approximately 25,000 snakebites occur annually, with Bothrops atrox responsible for most cases. Local morbidity is high, driven primarily by snake venom metalloproteases (SVMPs). The major SVMPs in B. atrox venom, Atroxlysin-Ia (ATXL) and Batroxrhagin (BATX), efficiently hydrolyze extracellular matrix proteins, inducing rapid hemorrhage and dermonecrosis. Thus, we characterized the composition of the exudate produced after SVMPs injection into the mice gastrocnemius muscle using proteomics. Muscle damage was evaluated by histological analysis. The composition of the exudate was analyzed by mass spectrometry. The SVMPs induced disorganization of muscle fibers and inflammatory cell migration. However, ATXL-induced a significantly higher neutrophil influx compared to BATX, likely triggered by an increase in CXCL16, suggesting a superior inflammatory capacity. In summary, despite being metalloproteases, these toxins exhibit distinct pathological profiles: ATXL is predominantly inflammatory, while BATX is more hemorrhagic. Interestingly, while endogenous serine proteinase levels were similar in both exudates, BATX showed significantly higher levels of proteinase inhibitors. Furthermore, identification of peptide bond cleavage sites revealed a pattern consistent with trypsin-like serine proteinases. These findings suggest that SVMPs not only damage tissue directly but also associate with the activation of host endogenous proteinases, which may contribute to the complex pathology of B. atrox envenomation, although direct causation remains to be established. - Source: PubMed
Chaves Alison Felipe AlencarTioyama Emilly CamposColombini MônicaGimenes Sarah N CCamargo Isabella Mitie deSilva Karina Maria PereiraSilveira Giovanni Perez Machado daSant'Anna Savio StefaniniFaquim-Mauro Eliana LimaSerrano Solange M TMoura-da-Silva Ana MFreitas-de-Sousa Luciana A - Asthma is a chronic inflammatory airway disease characterized by Th2- dominant immune responses, airway hyperresponsiveness, and structural remodeling. Although inhaled corticosteroids and biologics are effective for many patients, a substantial proportion remains poorly controlled and experiences treatment-related adverse effects. Probiotics have emerged as immunomodulatory agents in asthma, but existing studies predominantly focus on oral administration and gut-lung axis regulation. Whether direct respiratory administration of probiotics can modulate the pulmonary immune microenvironment and alleviate asthma remains largely unexplored. - Source: PubMed
Publication date: 2026/09/01
Yang XinYu FanWu XiaochengLi ShuxianWang YingshuoHu ZhongXie YichengMa DaqingWu Lei - Vitiligo is an autoimmune disorder marked by melanocyte destruction and epidermal depigmentation, primarily driven by inflammatory and oxidative stress within the affected skin lesions. Consequently, there is an urgent need for therapeutic strategies focused on protecting melanocytes and replenishing melanin for effective vitiligo management. In this study, a novel microneedle-based therapeutic platform (C/D/E@MN) was fabricated that was composed of cuttlefish ink nanoparticles (CINPs) for melanin supplementation, dipotassium glycyrrhizinate (DPG) for inflammation regulation, and skin-derived exosomes (EXO) to promote melanocyte proliferation. In addition, microneedles with varying dissolution profiles (swellable, slow-dissolving, and fast-dissolving) were designed and evaluated their performance to optimize therapeutic efficacy. In vitro results demonstrated that fast-dissolving microneedles (FDMN) significantly reduced cellular reactive oxygen species (ROS) and the secretion of vitiligo-related inflammatory cytokines and chemokines, such as IL-8, CXCL-16, and HMGB-1. Upon a vitiligo mice model, C/D/E@FDMN treatment group generated a significant increase in skin melanin content and a 15.5% reduction of whitening degree. The microneedles protected melanocytes and promoted lesion repigmentation through synergistic antioxidant, anti-inflammatory and cyto-proliferative mechanisms, offering a promising strategy for improved vitiligo therapy. - Source: PubMed
Publication date: 2025/08/06
Li WeimiaoShi YanZhan RuiminLiu LuWang JiaruiLee MinhyeockZhang BingqiangLiang ShaoshuaiWang ZhiguoKong Ming