PCOLN3 Antibody
- Known as:
- PCOLN3 Antibody
- Catalog number:
- XW-7713
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- PCOLN3 Antibody
Related genes to: PCOLN3 Antibody
- Gene:
- CHMP1A NIH gene
- Name:
- charged multivesicular body protein 1A
- Previous symbol:
- PRSM1, PCOLN3
- Synonyms:
- KIAA0047, CHMP1, Vps46A
- Chromosome:
- 16q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-05-03
- Date modifiied:
- 2015-09-07
Related products to: PCOLN3 Antibody
Related articles to: PCOLN3 Antibody
- Basal cell carcinoma (BCC) rarely metastasizes to other parts of the body. When metastasis occurs, it usually involves regional lymph nodes. BCC lesions located in the head and neck region have been shown to spread to cervical lymph nodes. Here, we present a case of a slow-growing lesion on the scalp that was diagnosed as a case of BCC. Metastasis to the level V cervical lymph nodes was already present at the time of diagnosis. The patient was managed with complete excision of the lesion, along with a neck dissection for level V lymph nodes, and adjuvant chemotherapy with Vismodegib. Molecular pathology results revealed a unique pattern, comprising the fusion of HMGA2-CHMP1A genes and a mutation involving a premature termination codon (PTC) in the CDKN2B gene. The post-operative work-up revealed a hypermetabolic nodule in level IIB lymph which is more likely inflammatory rather than metastatic. However, considering the possibility of metastasis, the patient is being followed up by a multi-disciplinary team (MDT) for evaluation of level IIB cervical lymph nodes. This case highlights the diagnostic and therapeutic challenges that may arise in rare cases of BCC with metastasis. - Source: PubMed
Publication date: 2026/04/12
Al-Hail NooraAl-Abdulla MajidRizvi SyedAl-Hayki Nazeeha - Endoplasmic Reticulum (ER) stress is implicated in Alzheimer's disease (AD) development. This study aims to identify ER stress-related genes associated with AD risk. - Source: PubMed
Publication date: 2025/11/26
Liang BingyuLi ManyuZhang Lin - Classical swine fever virus (CSFV) infection induces complete mitophagy, which is essential for the clearance of damaged mitochondria. The endosomal sorting complex required for transport (ESCRT) machinery plays a vital role in mediating phagophore closure and autophagosome-lysosome fusion during starvation-induced autophagy. Nevertheless, its involvement in CSFV-induced mitophagy and the underlying mechanisms remain insufficiently understood. Here, we found that the ESCRT-III subunits including CHMP1A, CHMP1B, and CHMP4B, along with the AAA-ATPase VPS4, were actively recruited to autophagosomes during CSFV-induced mitophagy. Consistent with this, depletion of CHMP1A, CHMP1B, CHMP4B or VPS4A disrupted mitophagic flux, impairing both PINK1-PRKN-dependent and -independent pathways. Further investigations revealed that CSFV transiently recruited these subunits to nascent autophagosomes for phagophore sealing during mitophagy. Remarkably, multiple CSFV nonstructural proteins (NSPs) including NS3, NS4B, NS5A and NS5B interacted with these ESCRT key subunits and colocalized on mitophagosomes. Taken together, our study identifies CHMP1A, CHMP1B, CHMP4B, and VPS4A as pivotal regulators of phagophore closure in CSFV-induced mitophagy, unveiling novel mechanisms by which the virus manipulates host cellular pathways and highlighting potential therapeutic targets for infection control.Abbreviation: ATF4: activating transcription factor 4; ATG5: autophagy related 5; BafA1: bafilomycin A; BFP: blue fluorescent protein; BNIP3L/NIX: BCL2 interacting protein 3like; BSA: bovine serum albumin; CALCOCO2/NDP52: calcium binding andcoiled-coil domain 2; CCCP: carbonyl cyanide 3-chlorophenylhydrazone; CHMP: charged multivesicular body protein; COX4: cytochrome c oxidase subunit 4; CSFV: classical swine fever virus; DAPI: 4',6-diamidino-2-phenylindole; DN: dominant-negative; ER: endoplasmic reticulum; ESCRT: endosomal sorting complex required for transport; FUNDC1: FUN14 domain containing 1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; hpt: hours post-transfection; HSPD1/HSP60: heat shock protein family D (Hsp60) member 1; IB: immunoblotting; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFF: mitochondrial fission factor; MFN2: mitofusin 2; MITO: mitochondria; MOI: multiplicity of infection; mtDNA: mitochondrial DNA; OPTN: optineurin; PBS: phosphate-buffered saline; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; RAPA: rapamycin; RFP: redfluorescent protein; RT-qPCR: reverse transcription-quantitativereal-time polymerase chain reaction; RT-PCR: real-time polymerasechain reaction; SD: standard deviation; siCtrl: negative control siRNA; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; TOMM20: translocase of outer mitochondrial membrane 20; VDAC1: voltage dependent anion channel 1; VPS4A: vacuolar protein sorting 4 homolog A; WCL: whole-cell lysate; WT: wild-type. - Source: PubMed
Publication date: 2025/07/09
Cheng YanLi YuhangBi XiaoqingChen JinxiaZhao BingqianBai JishanYe YinboDai QiZou LinkeChen JingFeng XiuliZhou Bin - To observe the effect of acupuncture on N6-methyladenosine (m6A) methylation and ferroptosis in brain tissue of mice with intracerebral hemorrhage (ICH), so as to explore its mechanisms underlying promoting neural function recovery. - Source: PubMed
Liu HaoDU JiaRuan ChenFeng Pei-PeiGuo Zhong-WeiLou Ke-LangYu Xiao-QingLi Xin-Wei - Disease outbreaks in aquaculture have recently intensified. In particular, visceral white-nodules disease, caused by , has severely hindered the small yellow croaker () aquaculture industry. However, research on this disease is limited. To address this gap, the present study employed a 100K SNP chip to genotype individuals from an F1 full-sib family, identify single nucleotide polymorphisms (SNPs), and construct a genetic linkage map for this species. A high-density genetic linkage map spanning a total length of 1395.72 cM with an average interval of 0.08 cM distributed across 24 linkage groups was obtained. Employing post-infection survival time as an indicator of disease resistance, 13 disease resistance-related quantitative trait loci (QTLs) were detected, and these regions included 169 genes. Functional enrichment analyses pinpointed 11 candidate disease resistance-related genes. RT-qPCR analysis revealed that the genes of and are significantly differentially expressed in response to infection in spleen and liver tissues, indicating their pivotal functions in disease resistance. In summary, in addition to successfully constructing a high-density genetic linkage map, this study reports the first QTL mapping for visceral white-nodules disease resistance. These results provide insight into the intricate molecular mechanisms underlying disease resistance in the small yellow croaker. - Source: PubMed
Publication date: 2024/10/10
Li QianZhu JiajieLiu SifangLiu HaowenZhang TianleYe TingLou BaoLiu Feng