FTH1 Antibody
- Known as:
- FTH1 Antibody
- Catalog number:
- XW-7700
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- FTH1 Antibody
Related genes to: FTH1 Antibody
- Gene:
- FTH1 NIH gene
- Name:
- ferritin heavy chain 1
- Previous symbol:
- FTHL6
- Synonyms:
- FTH, PLIF, PIG15, FHC
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: FTH1 Antibody
Related articles to: FTH1 Antibody
- Heat stress (HS) causes organ damage and has detrimental impacts on the welfare and production in broilers. As a crucial immune organ, the spleen exerts a key role in immune homeostasis of broilers. Fucoidan (FUC) is a marine functional substance and extracted from seaweeds with multiple biological activities, such as anti-inflammatory and antioxidant effects. This experiment attempted to investigate the protective effect of fucoidan on HS-induced spleen injury in broilers. A total of 240 male Arbor Acres (AA) broilers at 21 d of age were randomly assigned to five groups: control (CON) group, HS group, and HS group supplemented with 200 (HS+FUC), 400 (HS+FUC) and 800 (HS+FUC) mg/kg FUC. The feeding trial lasted 21 d. The results showed that HS reduced the spleen index, impaired antioxidant capacity, and induced pathological damage in the spleens of broilers. Dietary supplementation with 200, 400, and 800 mg/kg FUC alleviated these injuries. Specifically, 800 mg/kg FUC improved the spleen index, antioxidant indicators and the splenic histomorphological pathology in broilers under HS. Therefore, 800 mg/kg of FUC was identified as the effective dosage for mitigating HS-induced splenic injury in broilers. Accordingly, this study further investigated the molecular mechanism of the beneficial effects of 800 mg/kg FUC. FUC upregulated the expression of antioxidant genes (NQO1, CAT, SOD1, SOD2, GCLC, GCLM, GSTA3, HO-1) and ferroptosis-related genes (GPX4, SLC7A11, Fpn1, FTH1), while downregulating the expression of inflammatory genes (IL-1β, IL-4, TNF-α, NF-κB) in the spleen of heat-stressed broilers. Besides, FUC reduced the protein expression of total P65 and p-P65, and enhanced the protein expression of total Nrf2 and p-Nrf2 in the spleen of heat-stressed broilers. The findings demonstrated that dietary supplementation of 800 mg/kg FUC alleviates HS-induced spleen damage in broilers by reducing the oxidative stress, ferroptosis and inflammation, and the protective role of FUC is related to the activation of Nrf2 signaling and the suppression of NF-κB signaling. This study offers theoretical support for applying FUC in improving the spleen health of broilers under HS conditions. - Source: PubMed
Publication date: 2026/04/27
Liu Qian-QianChen YueLiang Qi-HaoTian Shan-ZiYao Qing-HuaYe Xue-QingChen Jun-HongLiu Wen-Chao - Hyperoxia-induced lung injury (HALI) is a common and severe complication in neonatal intensive care units, and there is currently no effective therapy available. Ferroptosis, a newly recognized form of iron-dependent regulated cell death, has recently been implicated in the pathogenesis of this disease. Ginsenosides are bioactive components extracted from ginseng. Among them, ginsenoside Rb1 (GsRb1) belongs to the protopanaxadiol-type saponins, and its molecular structure is CHO. This study aimed to investigate the protective effects and underlying mechanisms of GsRb1 in neonatal rats with hyperoxia-induced lung injury. - Source: PubMed
Publication date: 2026/05/06
Lian HuidanZhou HaiyuDong JieQian JunyiCheng YueLou JinyuZheng XinqiLin WeiJia Danyun - Intrauterine adhesion (IUA) is a significant contributor to uterine infertility, primarily characterized by endometrial fibrosis. Although diacerein exhibits anti-inflammatory and anti-fibrotic properties, its therapeutic potential in IUA remains unclear. This study investigated the protective effects of diacerein in an IUA rat model induced by mechanical injury. Histological analysis revealed that diacerein treatment alleviated endometrial damage, and immunohistochemical staining confirmed the restoration of CK19 and CK18 expression, indicating improved epithelial integrity and regeneration. Diacerein mitigated endometrial fibrosis by inhibiting epithelial-mesenchymal transition (EMT), as evidenced by increased E-cadherin and decreased N-cadherin expression, likely via suppression of TGFβ/SMAD2 signaling. Diacerein exerted anti-inflammatory effects in IUA rats. Notably, diacerein inhibited ferroptosis by reducing lipid peroxidation, limiting Fe²⁺ accumulation, and modulating ferroptosis-related proteins, including ACSL4, SLC7A11, GPX4, and FTH1. The protective effects of diacerein were mirrored by ferroptosis inhibitor Ferrostatin-1 treatment but reversed by ferroptosis inducer Erastin, confirming that diacerein alleviates endometrial fibrosis in IUA rats through ferroptosis suppression. Mechanistically, diacerein modulated the NRF2/HMGB1 signaling pathway, restoring NRF2 and HO1 levels while downregulating HMGB1 expression. Collectively, these findings suggest that diacerein effectively attenuates ferroptosis-mediated fibrosis in IUA, highlighting ferroptosis inhibition as a promising therapeutic strategy for IUA management. - Source: PubMed
Publication date: 2026/05/02
Shi CongSun JianhuaNiu Jumin - Ferroptosis of type II alveolar epithelial (AT2) cells plays a crucial role in the pathological progression of acute lung injury (ALI). Although fibroblast growth factor-2 (FGF2) has been shown to exert protective effects against ALI, the underlying mechanisms remain largely unexplored. - Source: PubMed
Publication date: 2026/04/17
Wang YanZhu PingjunDing YongkaiHan XinjieWang XiWu ShengHuai SiyuanLi NanXu GuogangDu Yingzhen - Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and oxidative stress, increasingly implicated in cancer biology. However, its molecular regulation across breast cancer subtypes and its potential systemic manifestations remain incompletely understood. The aim of this study was to identify ferroptosis-associated molecular alterations that are largely shared across subtypes and to evaluate their systemic reflection following localized tissue injury. Tumor and matched normal breast tissues representing major molecular subtypes were analyzed. Global mRNA and miRNA expression profiling was performed using microarrays, followed by validation of selected genes using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Functional enrichment and protein-protein interaction analyses were conducted to characterize associated pathways. In addition, systemic responses were assessed in patients undergoing fibroadenoma cryoablation through longitudinal blood sampling. Six ferroptosis-related genes (, , , , , ) demonstrated consistent upregulation across all breast cancer subtypes, with higher expression observed in more aggressive tumors. These genes are functionally linked to antioxidant defense, iron metabolism, and oxidative stress regulation, and their coordinated expression pattern is consistent with activation of NRF2-dependent cytoprotective pathways. Downregulation of selected miRNAs may contribute to this expression profile but likely represents a secondary regulatory mechanism. Survival analysis revealed heterogeneous and subtype-dependent associations, with limited and gene-specific prognostic relevance. Cryoablation induced transient increases in circulating levels of the analyzed proteins, reflecting systemic responses to localized tissue injury. In conclusion, breast cancer is characterized by a largely shared ferroptosis-associated molecular signature across subtypes; however, its clinical impact appears to be variable and context-dependent. Systemic detection of related molecular signals suggests potential utility as indicators of tissue stress responses, although their role as specific biomarkers of ferroptosis requires further validation. - Source: PubMed
Publication date: 2026/04/12
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