PPP1CC Antibody
- Known as:
- PPP1CC Antibody
- Catalog number:
- XW-7673
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- PPP1CC Antibody
Related genes to: PPP1CC Antibody
- Gene:
- PPP1CC NIH gene
- Name:
- protein phosphatase 1 catalytic subunit gamma
- Previous symbol:
- -
- Synonyms:
- PP1C, PP1gamma
- Chromosome:
- 12q24.11
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-01
- Date modifiied:
- 2016-10-05
Related products to: PPP1CC Antibody
Related articles to: PPP1CC Antibody
- Triptolide (TPL), the core active component of the traditional Chinese medicinal herb Hook F (TwHF), possesses a wide spectrum of pharmacological activities, including anti-inflammatory, neuroprotective, immunosuppressive, and anti-tumor activities. However, its clinical application is severely limited by significant reproductive toxicity, the mechanism of which remains poorly understood. Using an integrated analysis of MeRIP-seq and mRNA-seq data, coupled with experimental validation in HTR-8/SVneo cells, we systematically elucidated the molecular mechanism by which TPL induces trophoblast cell injury. Our findings revealed that TPL significantly altered intracellular N-methyladenosine (mA) modification and gene expression profiles, with 1774 genes displaying hypomethylation concurrent with mRNA upregulation. According to the functional enrichment analysis, these genes showed significant enrichment in several key pathways associated with reproduction, including autophagy, DNA damage response, mitochondrial outer membrane, and positive regulation of apoptotic process. Molecular docking further demonstrated direct and stable binding of TPL to key mA regulators, leading to specific demethylation of targets including and . This study uncovers a novel post-transcriptional mechanism where TPL disrupts mA modification, thereby perturbing essential trophoblast functions and driving reproductive toxicity. - Source: PubMed
Publication date: 2026/04/16
Liu XinruWu YunliTian JinWen JiaxinShi YuanWang LiliZhu AnWu Zekai - Alzheimer's disease (AD) is a neurodegenerative disorder. Asiaticoside (AS), one of the main active components of Centella asiatica, shows therapeutic potential in various diseases, including AD. However, the specific molecular mechanisms by which AS treats AD remain unclear. - Source: PubMed
Zhang PengfeiXie JiangtaoLiu LiangZheng YuYang Ye - [This corrects the article DOI: 10.1016/j.isci.2024.110847.]. - Source: PubMed
Publication date: 2026/02/19
Han YameiXiao MingmingZhao ShaorongWang HanLi RuiXu Bo - The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos. However, how YAP undergoes dephosphorylation specifically in the trophectoderm (TE) but not in the inner cell mass (ICM) remains unresolved. Here, we discovered that the serine/threonine phosphatase PPP1CC exhibits uniform distribution prior to blastocyst formation but becomes specifically localised to the TE during the blastocyst stage. Through mediating YAP dephosphorylation in the outer cells of mouse morula, PPP1CC facilitates YAP nuclear translocation, thereby ultimately driving TE lineage specification. Importantly, the spatially restricted localisation of PPP1CC in TE is achieved via its interaction with the long non-coding RNA GAS5, which localises to the subcortical region throughout early mouse embryonic development. Knockdown of GAS5 phenocopies PPP1CC deficiency, causing developmental arrest at the morula stage accompanied by impaired YAP dephosphorylation in outer cells. Moreover, overexpression of GAS5 in one blastomere of the 2-cell stage biases its descendants predominantly towards the TE fate. In summary, our study identifies the GAS5-PPP1CC-YAP axis as a central regulator of first lineage specification during mouse preimplantation development, highlighting its critical role in reversible phosphorylation during early embryogenesis. - Source: PubMed
Publication date: 2025/12/16
Wang JianwuZhang YanWu LaijinXie HongshuangYang GuangZhang YiweiHuang ChengChou ShanyiLi XuehanLiu ZhonghuaWang Jiaqiang - Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet (PLT) destruction. Its clinical manifestations are highly heterogeneous, and the unclear pathogenesis poses significant challenges for effective treatment. The limited efficacy of current therapies underscores the need for novel therapeutic targets. - Source: PubMed
Publication date: 2025/11/01
Li XiaoliLi JunLan YangWan YangYang WenyuZhu Xiaofan