UQCRC2 (C-223) Antibody
- Known as:
- UQCRC2 (C-223) Antibody
- Catalog number:
- XW-7645
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- UQCRC2 (C-223) Antibody
Related genes to: UQCRC2 (C-223) Antibody
- Gene:
- UQCRC2 NIH gene
- Name:
- ubiquinol-cytochrome c reductase core protein 2
- Previous symbol:
- -
- Synonyms:
- QCR2, UQCR2
- Chromosome:
- 16p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-09
- Date modifiied:
- 2017-09-12
Related products to: UQCRC2 (C-223) Antibody
Related articles to: UQCRC2 (C-223) Antibody
- The developmental pace and sex ratio of preimplantation embryos have major implications for pregnancy outcome and herd replacement. We asked whether selecting embryos that develop faster preferentially captures distinct molecular and metabolic states and inadvertently affects the sex ratio in bovine in vitro produced (IVP) blastocysts. Hatching-stage blastocysts (pool of blastocysts undergoing and having completed the hatching process) developed on Day 7 and Day 8 of in vitro culture (IVC) were analyzed by RNA-sequencing, alongside assessments of lipid content, mitochondrial activity, and reactive oxygen species (ROS). Sexing was performed via Y-chromosome multiplex PCR, and candidate genes were quantified by qPCR in individually sexed hatching-stage embryos. RNA-sequencing identified 192 differentially expressed genes. Notably, significantly higher expression of pregnancy recognition factors (IFNT2, IFNT3) and the trophoblast marker TKDP1, along with glycolytic, lipid transport genes was observed on Day 8. In contrast, hatching-stage blastocysts from Day 7 displayed upregulation of oxidative phosphorylation genes. Mitochondrial activity and ROS levels were comparable between groups, but Day 7 embryos contained significantly more lipids. Interestingly, sexing analysis revealed a significant male bias among these blastocysts on Day 7 (66.7%) and Day 8 (58.5%). Candidate gene expression analysis revealed sexually dimorphic regulation of UQCRC2 and developmental day-dependent regulation of ENO1, UQCRC2, HSP90B1, and APOA1. Collectively, these findings indicate that hatching-stage blastocysts developed on Day 7 and Day 8 of IVC represent distinct physiological states and demonstrate that selecting embryos for rapid development can inadvertently skew sex ratios and molecular profiles in bovine IVP embryos. - Source: PubMed
Publication date: 2026/04/24
Baddela Vijay SimhaFersterer TheresPöhland Ralfde Andrade Melo-Sterza FabianaLudwig Carolin L MBecker DoreenKühn ChristaVanselow Jens - Ubiquinol-cytochrome c reductase core protein II () encodes a core subunit of the mitochondrial electron transport chain (ETC) complex III (CIII). Biallelic pathogenic variants in have been associated with mitochondrial disease characterized by lactic acidosis, developmental delay, hepatopathy, and episodic metabolic decompensation. - Source: PubMed
Publication date: 2026/03/27
Preston GraemeShammas IbrahimPinto E Vairo FilippoLigezka AnnaAschoff Carlos Alberto de MouraPoswar FabianoSchwartz Ida Vanessa DKozicz TamasMorava Eva - Acute myocardial infarction (AMI) requires timely restoration of cardiac perfusion, which often leads to myocardial ischemia/reperfusion injury (MIRI). Ferroptosis, apoptosis, and mitochondrial dysfunction play critical roles in this process. Astragaloside IV (Ast) has been demonstrated to possess multiple biological functions, yet its protective mechanisms against MIRI remain unclear. - Source: PubMed
Publication date: 2026/03/18
Zeng Rui-YuanQiu Zhi-CongZhao Shi-TaoLai Song-QingQiu Rong-BinWu Zi-MingXu Zhi-QiangLi Jian-NanLuo Xu-DongWang Bo-LongWan Li - Mitochondrial dysfunction is central to Parkinson's disease (PD), but assessing it in vivo remains challenging. Plasma L1CAM-immunocaptured putative neuron-derived exosomes (NDEs) offer minimally invasive access to brain molecular signatures. This study investigated whether mitochondrial complex (MC) proteins in NDEs are altered in PD and explored their association with clinical features. Plasma putative NDEs were isolated from 28 patients with PD and 33 normal controls (NCs) by L1CAM immunocapture. Levels of mitochondrial subunits-NDUFS3 (Complex I), UQCRC2 (Complex III), MT-CO1 (Complex IV), and ATP5F1A (Complex V)-and the antioxidant enzyme SOD1 were quantified by ELISA. Correlations with clinical severity and diagnostic performance were analyzed. Compared with NCs, PD patients exhibited significantly lower levels of NDUFS3 and UQCRC2 in NDEs (p < 0.05, after FDR correction). NDUFS3, UQCRC2, and SOD1 showed modest inverse correlations with motor symptom severity (R = -0.26). The NDUFS3/UQCRC2 combination yielded an AUC of 0.763 (95% CI: 0.638-0.862) with 100% sensitivity and 51.5% specificity in this exploratory cohort, indicating limited discriminative capacity. These exploratory findings suggest that mitochondrial proteins within plasma putative NDEs may reflect neuronal mitochondrial alterations in PD. The NDUFS3/UQCRC2 combination represents a candidate signature warranting validation in larger cohorts. - Source: PubMed
Publication date: 2026/03/26
Yao YunxiaLi YuanZhao ChunsongYu QianLi QimengMao WeiZhao LifangCai Yanning - During boar semen cryopreservation, reduction in sperm quality and mitochondrial dysfunction are often accompanied by a pronounced increase in oxidative stress, well acknowledged as a key factor contributing to sperm functional impairment following freeze-thaw. Moreover, conventional components in freezing extenders may exert detrimental effects on sperm under certain conditions. Consequently, supplementation of antioxidants that specifically alleviate oxidative stress while maintaining both safety and efficacy represents a critical strategy for further optimization of boar semen cryopreservation. The ginkgo biloba extract (GBE) holds potent antioxidant and anti-inflammatory properties. In this study, different concentrations of GBE (0, 25, 50, 75, and 100 mg/L) were added to the freezing extender, and their effects on post-thaw porcine sperm quality were assessed. The results demonstrated that GBE at 25-100 mg/L significantly improved sperm motility and plasma membrane, acrosome, and DNA integrity. GBE also markedly increased adenosine triphosphate (ATP) content, mitochondrial membrane potential (MMP), and the protein levels of mitochondrial respiratory chain complexes (UQCRC2 and NDUFB8), while reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels and enhancing antioxidant enzyme activities. Besides, GBE significantly augmented anti-apoptotic capacity and sperm capacitation. The subsequent mechanistic exploration revealed that GBE could alleviate the porcine sperm cryodamage by suppressing KEAP1 expression, activating the NRF2/HO-1/NQO1 signaling, and upregulating AKT and ERK phosphorylation. Altogether, this study elucidates the role and mechanisms for GBE in porcine semen cryopreservation, providing novel theoretical insights and practical guidance for improvement of sperm quality and reproductive performance in pigs. - Source: PubMed
Publication date: 2026/03/18
Li WanyingLin RenjianWang ShengmingZhou PeichuPang WeijunFeng TongyingZheng Yi